A5101761102- Liver Disease Diagnosis and Treatment
- Hepatocellular Carcinoma Treatment and Prognosis
- MicroRNA in disease regulation
- Cancer, Lipids, and Metabolism
- Cancer-related molecular mechanisms research
- Liver Diseases and Immunity
- Diet, Metabolism, and Disease
- COVID-19 Clinical Research Studies
- Adipokines, Inflammation, and Metabolic Diseases
- Renal and Vascular Pathologies
- Neurological Disorders and Treatments
- Heme Oxygenase-1 and Carbon Monoxide
- Extracellular vesicles in disease
- RNA Research and Splicing
- Alcohol Consumption and Health Effects
- Long-Term Effects of COVID-19
- Liver Disease and Transplantation
- Diet and metabolism studies
- Inflammasome and immune disorders
- Vasculitis and related conditions
- Delphi Technique in Research
- Ophthalmology and Eye Disorders
- Renal Transplantation Outcomes and Treatments
- Corneal surgery and disorders
- COVID-19 Impact on Reproduction
Qingdao Municipal Hospital
2014-2024
Qingdao University
2014-2024
First Hospital of Jilin University
2024
Jilin University
2022-2024
Beijing Children’s Hospital
2022-2024
Center for Children
2024
Capital Medical University
2022-2024
Ocean University of China
2023
Xiamen University
2022
Capital University
2022
The 2019 novel coronavirus disease, SARS-CoV-2, is now spreading globally and characterized by person-to-person transmission. However, it has recently been found that individuals infected with SARS-CoV-2 can be asymptomatic, simultaneously a source of infection in others. viral load detected nasopharyngeal swabs asymptomatic carriers relatively high, great potential for More attention should paid to the insidious spread disease harm contributed carriers. To provide theoretical basis accurate...
The biogenesis and diagnostic value of exosomes in nonalcoholic fatty liver disease (NAFLD) are unclear. In this study, we revealed that the plasma exosome level was higher patients with NAFLD than healthy controls. Damage-regulated autophagy modulator (DRAM) identified as one genes related to secretion NAFLD. Then, loss or knockdown DRAM down-regulated from hepatic cells using a knockout mouse model cell model. reversed high-fat diet–induced increase secreted exosomes. Furthermore,...
DNA damage-regulated autophagy modulator 1 (DRAM1) could play important roles in inflammation and hepatic apoptosis, while its alcohol-related liver disease (ALD), which is characterized by are still unclear. In this study, we explored the expression, role, mechanism of DRAM1 ALD. Firstly, our results showed that was significantly increased tissues mice at early stage alcohol treatment. addition, knockout reduced, liver-specific overexpression aggravated, alcohol-induced steatosis, injury,...
MicroRNAs (MiRNAs) are known to participate in preadipocyte differentiation, but the manner which miR-146a-5p participates this process remains unclear. This study was performed examine participation of 3T3-L1 cell differentiation.miR-146a-5p expression upregulated and down-regulated effects on differentiation. Bioinformatics analysis predict its target genes, signaling pathway it regulates identified by qRT-PCR Western blotting. The epididymal adipose tissue from obese mice an mouse model...
Corneal fibrosis is a complication of severe corneal injury, one the major causes vision loss. The formation myofibroblasts has emerged as key stimulative factor fibrosis. In current study, we focused on role LINC00963 in regulating Transforming growth β1 (TGF-β1) was used to induce human stromal cells differentiating into myofibroblasts, and significant increase α-smooth muscle actin (α-SMA) verified by quantitative real-time PCR (qRT-PCR), western blot, immunofluorescence, respectively....
<br><b>Background/Aims</b>: The role of two polymorphisms rs1800591 and rs3816873 the microsomal triglyceride transfer protein (MTTP) gene in development nonalcoholic fatty liver disease (NAFLD) remains controversial. A meta-analysis was conducted to determine correlation between these MTTP NAFLD.<br><b>Materials Methods</b>: systematic search carried out using PubMed, Embase, Cochrane Library retrieve English studies that reported relationship (rs1800591 rs3816873) NAFLD published before...
Rationale: Renal artery rupture due to allograft infection, especially by fungi, is a serious clinical complication that can occur after kidney transplantation, and may lead graft loss death. Patient concerns: Two recipients from China who developed renal at our hospital on 5 days (47-year-old female) 45 (39-year-old male) surgery. Diagnoses: The male had immunoglobulin A nephropathy as primary disease, experienced postoperative attack of vascular rejection mixed infection Mucor bacteria....
ABSTRACT Hypothesis The present study was conducted to explore the role of NOD-like receptor family pyrin domain-containing 3 (NLRP3) inflammasome in mouse otic barotrauma models. Background Previous studies suggest that NLRP3 plays an important pathogenesis middle ear disease. However, whether negative pressure injury underlies activation remains unclear. Methods Wild-type and Nlrp3−/− mice were randomly assigned control groups, respectively. Pressure loading performed using a cabin with...
Objective To explore clinical features and pathogenesis of diabetes-associated ophthalmoplegia.Methods Sixty-five cases which were admitted ophthalmoplegia with type 2 diabetes from June 2008 to 2013 in our hospital retrospectively analyzed.Results Among 65 cases,monocular involvement ptosis the upper eyelid occurred 4 cases,61 suffered diplopia without pupillary abnormality,42 healed.The treatment time was 55 97 days; 17 better 6 had no change.Conclusions Diabetes-associated is mostly acute...
Abstract Nonalcoholic fatty liver disease (NAFLD) is a multifactorial metabolic syndrome which could develop into hepatocellular carcinoma (HCC). Exosomes mediate intercellular communications and play key roles in the occurrence development of many diseases including NAFLD HCC. However, expressions genes related to exosomes NAFLD-related HCC remain unclear. The objective this study was investigate diagnostic values exosome-related Firstly, we identified 15 exosome secretion by database...
Objective To compile and evaluate the questionnaire of knowledge, belief practice perioperative nurses in prevention deep venous thrombosis (DVT) order to provide a tool for further investigation status quo nursing care DVT during period. Methods Based on theoretical model practice, item pool was established by literature reading semi-structured interviews, an initial formed Delphi expert inquiry. It convenient select 197 engaged surgery operating room Qingdao Municipal Hospital...