A5081150732- Antibiotics Pharmacokinetics and Efficacy
- Bacterial Identification and Susceptibility Testing
- Antimicrobial Resistance in Staphylococcus
- Healthcare Policy and Management
- Antibiotic Use and Resistance
- Primary Care and Health Outcomes
- COVID-19 Clinical Research Studies
- Long-Term Effects of COVID-19
- Healthcare Systems and Technology
- Orthopedic Infections and Treatments
- Clostridium difficile and Clostridium perfringens research
- Pneumocystis jirovecii pneumonia detection and treatment
- Intramuscular injections and effects
- Nosocomial Infections in ICU
- Hemodynamic Monitoring and Therapy
- Infectious Diseases and Tuberculosis
- Patient Satisfaction in Healthcare
- Salmonella and Campylobacter epidemiology
- Innovations in Medical Education
- Blood disorders and treatments
- SARS-CoV-2 and COVID-19 Research
- Immunodeficiency and Autoimmune Disorders
- HIV/AIDS Research and Interventions
- Healthcare Operations and Scheduling Optimization
- Burn Injury Management and Outcomes
Infectious Disease Consultants
2013-2024
Rush University Medical Center
1985-1986
Presbyterian St. Luke's Medical Center
1985-1986
Abstract A panel of experts was convened by the Infectious Diseases Society America (IDSA) to update 2004 clinical practice guideline on outpatient parenteral antimicrobial therapy (OPAT) [1]. This is intended provide insight for healthcare professionals who prescribe and oversee provision OPAT. It considers various patient features, infusion catheter issues, monitoring questions, stewardship concerns. does not offer recommendations treatment specific infections. The reader referred disease-...
Background. In the United States, Klebsiella pneumoniae carbapenemase (KPC)–producing Enterobacteriaceae are increasingly detected in clinical infections; however, colonization burden of these organisms among short-stay and long-term acute care hospitals is unknown.
Background. Previous studies, largely based on chart reviews with small sample sizes, have demonstrated that infectious diseases (ID) specialists positively impact patient outcomes. We investigated how ID mortality, utilization, and costs using a large claims dataset. Methods. used administrative fee-for-service Medicare to identify beneficiaries hospitalized from 2008 2009 at least 1 of 11 infections. There were 101 991 stays 170 336 without interventions. Cohorts propensity score matched...
Abstract A panel of experts was convened by the Infectious Diseases Society America to update 2004 clinical practice guideline on outpatient parenteral antimicrobial therapy (OPAT) [1]. This is intended provide insight for healthcare professionals who prescribe and oversee provision OPAT. It considers various patient features, infusion catheter issues, monitoring questions, stewardship concerns. does not offer recommendations treatment specific infections. The reader referred disease- or...
From June 1985 to September 1987, 202 adults were enrolled in a randomized, double-blinded study comparing ciprofloxacin (500 mg) with sulfamethoxazole and trimethoprim (160 mg/800 or placebo for acute diarrhea. All patients treated on the day of presentation received medication twice-daily schedule (every 12 hours) 5 days. Bacterial isolates from these included 35 Campylobacter, 18 Shigella, 15 Salmonella. Treatment at time compared shortened duration diarrhea (2.4 vs 3.4 days), increased...
Infectious diseases (ID) specialists have played a major role in patient care, infection control, and antibiotic management for many years. With the rapidly changing nature of health it has become necessary ID to articulate their value multiple audiences. This article summarizes versatile attributes possessed by delineates patients, hospitals, other integral groups care continuum.
The in vitro susceptibility of 27 Campylobacter jejuni, 31 coli, and 30 fetus subsp. strains to 12 antimicrobial agents was determined. Ciprofloxacin, a new quinoline derivative, the most active agent tested. Antimicrobial differed among three species
Outpatient parenteral antimicrobial therapy (OPAT) can be managed by specialists in infectious diseases (ID) or other physicians. Better management of OPAT reduce the likelihood readmission emergency department (ED) use. The relative success ID and physicians managing has received little study.We analyzed a national database insurance claims for privately insured individuals under age 65, locating inpatient acute-care stays 2013 2014 that were followed OPAT. Through propensity scoring,...
Acute osteomyelitis is typically caused by Gram-positive pathogens, commonly antibiotic-resistant Staphylococcus species. Standard antibiotic treatment challenging due to required multiple daily doses, therapeutic drug monitoring, and parenteral administration for at least 4 weeks. Oritavancin a long-acting lipoglycopeptide approved as single 1200 mg dose the of adult patients with acute bacterial skin structure infections.To characterize real-world use, efficacy, safety oritavancin in...
Weekly intravenous (IV) oritavancin and daily daptomycin were compared in an outpatient setting following extensive surgical debridement for treating patients with osteomyelitis. This was a retrospective, observational study of diagnosed acute Exclusion criteria the use Gram-negative antibiotic therapy, antibiotics more than 48 h prior to or > 2 doses 4 weeks daptomycin. Clinical success resolution improvement symptoms no further treatment. Data analyzed Chi-square test Fisher's exact test....
Abstract Background. Outpatient parenteral antibiotic therapy (OPAT) is a safe and effective modality for treating serious infections. This study was undertaken to define the value of OPAT in multicentered infectious disease (ID) private practice setting. Methods. Over period 32 months, 6120 patients were treated using 19 outpatient ID offices 6 states. Analysis included patient demographics, indications OPAT, diagnoses, therapeutic agent, duration therapy, site initiation. Outcomes...
Tocilizumab is an IL-6 receptor antagonist with the ability to suppress cytokine storm in critically ill patients infected severe acute respiratory syndrome-coronavirus 2 (SARS-CoV-2). We evaluated treated tocilizumab for a SARS-CoV-2 infection who were admitted between March 13, 2020, and April 16, 2020. This was multicenter study data collected by chart review both retrospectively concurrently. Parameters included age, sex, race, use of mechanical ventilation (MV), usage steroids...
Eravacycline is a novel fluorocycline approved for treatment of intraabdominal infections, with broad spectrum activity against range pathogens including multidrug-resistant species, ESBL- or KPC-producing isolates. It twice-daily dosing no need adjustment in renal dysfunction. In the concomitant administration CYP 3A4-inducing drugs, eravacycline should be modified. To evaluate efficacy and safety infections such as pneumonia diabetic foot seriously ill patients. A retrospective...
Abstract Background Tocilizumab is an IL-6 receptor antagonist with the ability to suppress cytokine storm in critically ill patients infected SARS-CoV-2. Methods We evaluated treated tocilizumab for a SARS-CoV-2 infection who were admitted between 3/13/20 and 4/16/20. This was multi-center study data collected by chart review both retrospectively concurrently. Parameters included age, sex, race, use of mechanical ventilation (MV), usage steroids vasopressors, inflammatory markers,...
To identify the most efficacious timing for tocilizumab administration in critically ill patients infected with severe acute respiratory syndrome coronavirus-2.Observational multicenter cohort study.A total of 23 care hospitals four states.One-hundred eighteen admitted between March 13, 2020, and April 16, 2020. Eighty-one received tocilizumab, 37 were untreated served as a control group.The main outcome was mortality analyzed by dosing. Early dosing defined dose administered prior to or...
Ciprofloxacin was compared with erythromycin for the eradication of Campylobacter species that were chronically excreted in stools marmosets (Saguinus labiatus labiatus, Saguinus fuscicollis nigrifrons, and illigeri). Stool cultures negative within 48 h beginning treatment either agent. Within 10 days after end therapy, however, again isolated from six animals had received erythromycin. During an 8-week follow-up period, no animal ciprofloxacin relapsed. High levels stool (mean, 49.2...
Abstract Background SARS-CoV-2 is a novel coronavirus that has rapidly expanded to become pandemic, resulting in millions of deaths worldwide. The cytokine storm caused by the release inflammatory agents and results physiologic disruption. Tocilizumab an IL-6 receptor antagonist with ability suppress critically ill patients infected SARS-CoV-2. Methods This was multi-center study SARS-CoV-2, admitted between 3/13/20 4/16/20, requiring mechanical ventilation. Parameters were evaluated...
Abstract Haemophilus influenzae meningitis in the presence of a cerebrospinal fluid shunt has been reported uncommonly. Staphylococcus aureus and epidermidis, most common etiological agents, are usually acquired by contiguous spread from an intraoperative or perioperative source. These infections occur within 2 months insertion rarely associated with bacteremia. Review literature shows that infection H. typically occurs later than more pathogens, is commonly bacteremia, frequently can be...
The association of a skin ulcer (lesion) with regional or distant lymphadenopathy (LAD) has been termed (U)/node (N) syndrome. existence both adenopathy and ulcerative lesions in patient can narrow diagnostic possibilities. Appropriate blood microbiologic exams help confirm the diagnosis. This syndrome is further classified one four categories: 1. Predominant (N greater than U) 2. Lymphadenopathy only 3. (U N) 4. Ulcer
Abstract Background Staphylococcus aureus is a significant cause of bacteremia and associated with high morbidity mortality rates. In patients S. bacteremia, studies have proven that intravenous antibiotics are needed for the entire course therapy. For some groups patients, specifically in persons who inject drugs (PWID), long-term use IV not safe or feasible. this population, current options would be obtaining access daily antibiotic infusions, oral antibiotics, being admitted to facility...
Despite the stimulating nature of infectious diseases (ID), fellowship programs have failed, on a yearly basis, to fill multiple positions. In addition, numerous entities published information showing that disease physicians are poorly reimbursed compared their colleagues in other specialties and likely feel overwhelmed. To assess status our ID group define opportunities for improvement, Metro Infectious Disease Consultants (MIDC) conducted an internal audit. Eighty-nine percent physician...
The Infectious Diseases Society of America (IDSA) conducted a survey in 1998 to characterize its membership and determine their needs. response rate was 39%. Although only 23% the respondents spent most time field teaching research, 62% listed an academic institution as primary employer. According results, 17% indicated that care HIV-infected patients comprised one-half or more practices. Respondents noted shortcomings training result recent changes clinical practice arena health system;...