A5103261362- Synthetic Organic Chemistry Methods
- Synthesis and Characterization of Heterocyclic Compounds
- Sperm and Testicular Function
- Pluripotent Stem Cells Research
- Synthesis and Reactions of Organic Compounds
- Asymmetric Synthesis and Catalysis
- Synthesis and Reactivity of Sulfur-Containing Compounds
- Chemical Reaction Mechanisms
- Monoclonal and Polyclonal Antibodies Research
- Steroid Chemistry and Biochemistry
- Microbial Inactivation Methods
- Cyclopropane Reaction Mechanisms
- Antibiotic Resistance in Bacteria
- Pancreatitis Pathology and Treatment
- Neonatal Respiratory Health Research
- Immune Cell Function and Interaction
- Oxidative Organic Chemistry Reactions
- Marine Sponges and Natural Products
- Viral Infectious Diseases and Gene Expression in Insects
- Inflammatory mediators and NSAID effects
- Hepatocellular Carcinoma Treatment and Prognosis
- Organophosphorus compounds synthesis
- Reproductive Biology and Fertility
- Plant Reproductive Biology
- Immunodeficiency and Autoimmune Disorders
University of Ostrava
2014
Leibniz University Hannover
2010-2012
Medizinische Hochschule Hannover
2010
Heinrich Heine University Düsseldorf
2009
Charles University
1985-1999
Three major cytoskeletal proteins, actin, tubulin and spectrin, are present in the head of mammalian spermatozoa. Although proteins implicated regulation capacitation acrosome reaction (AR), their exact role remains poorly understood. The aim this study was to compare distribution sperm cytoskeleton before after AR spermatozoa representing a range size shape. Spermatozoa from human three rodents (rat, hamster grey squirrel) were fixed appropriate medium vitro. Indirect immunofluorescent...
The asymmetric synthesis of jaspine B (pachastrissamine) using a (R)-proline-catalyzed enantioselective aldol reaction as key step is described. Jaspine was synthesized from the commercially available and inexpensive 1-pentadecanal dihydroxyacetone equivalent 2,2-dimethyl-1,3-dioxan-5-one in nine steps, good overall yield (23.6%) excellent stereoselectivity (de >98%, ee = 95%).
Abstract Vinylcyclopropanes are versatile intermediates and products in organic synthesis. The corresponding enantiomerically pure boronic esters should lead to highly flexible building blocks with a variety of applications. A detailed study towards the selective synthesis ( E )‐ Z )‐vinyl derivatives starting from known diastereo‐ enantiopure cyclopropylmethanols 3 4 is presented. were activated via their trifluoroboronates; optimization reaction discussed. endeavour culminated (–)‐(1 S ,2...
Alveolar epithelial type II (ATII)-like cells can be generated from murine embryonic stem (ESCs), although to date, no robust protocols applying specific differentiation factors are established. We hypothesized that the keratinocyte growth factor (KGF), an important mediator of lung organogenesis and primary ATII cell maturation proliferation, together with dexamethasone, 8-bromoadenosine-cAMP, isobutylmethylxanthine (DCI), which induce fetal cells, also support alveolar ESCs. Here we...
A practical synthesis of the Rho-Kinase inhibitor Y-27632 and two new fluoro derivatives was achieved in seven steps with a good overall yield 45% starting from commercially available (R)-1-phenylethylamine. Compared to showed reduced or no effect on hPSC vitality expansion after dissociation human pluripotent stem cells.
The asymmetric synthesis of the antitumor and immunostimulatory α-d-galactosyl ceramide KRN7000 using a (R)-proline-catalyzed enantioselective aldol reaction as key step is described. title compound synthesized in thirteen linear steps with excellent stereoselectivity (de >98%, ee = 95%) employing commercially available substrates 1-pentadecanal, 2,2-dimethyl-1,3-dioxan-5-one, hexacosanoic acid, d-galactose.
The total synthesis of dictyopterene A was accomplished via an enantiomerically pure cyclopropylboronic ester building block. Crucial olefination steps were carried out employing the Julia-Kocienski as well Wittig reactions. Matteson homologation final key step for synthesis.
The aim of this study is to inform about the development a new semispherical surgical instrument for bipolar multielectrode radiofrequency liver ablation. Present tools are universal; however they have several disadvantages such as ablation healthy tissue, numerous needle punctures, and, therefore, longer operating procedure. Our newly designed and tested tool can solve some these disadvantages. By conducting an in vivo on set 12 pigs, randomly divided into two groups, we compared efficiency...
Abstract ChemInform is a weekly Abstracting Service, delivering concise information at glance that was extracted from about 100 leading journals. To access of an article which published elsewhere, please select “Full Text” option. The original trackable via the “References”
Abstract Die Cyclokondensation der Ketonitrile (Ia)‐(Ic) zu den Pyranen (IIa)‐(IIc) ergibt die besten Ausb. bei azeotroper Abdestillation des entstehenden Wassers während Reaktion.
Abstract Die Derivate (Ib) und (Ic) der Titelverbindung (Ia) lassen sich nach Standardmethoden darstellen.
Abstract ChemInform is a weekly Abstracting Service, delivering concise information at glance that was extracted from about 100 leading journals. To access of an article which published elsewhere, please select “Full Text” option. The original trackable via the “References”
Abstract ChemInform is a weekly Abstracting Service, delivering concise information at glance that was extracted from about 100 leading journals. To access of an article which published elsewhere, please select “Full Text” option. The original trackable via the “References”