A5066150864- Cancer Genomics and Diagnostics
- Lung Cancer Diagnosis and Treatment
- Radiomics and Machine Learning in Medical Imaging
- Genetic factors in colorectal cancer
- Pancreatic and Hepatic Oncology Research
- Cancer-related Molecular Pathways
- Lung Cancer Treatments and Mutations
- Pneumocystis jirovecii pneumonia detection and treatment
- Nonmelanoma Skin Cancer Studies
- Parkinson's Disease and Spinal Disorders
- Cancer Treatment and Pharmacology
- Cytomegalovirus and herpesvirus research
- Cutaneous lymphoproliferative disorders research
- Neonatal Health and Biochemistry
- Neutropenia and Cancer Infections
- vaccines and immunoinformatics approaches
- Escherichia coli research studies
- Pain Mechanisms and Treatments
- Nanoplatforms for cancer theranostics
- Chronic Lymphocytic Leukemia Research
- Lung Cancer Research Studies
- CRISPR and Genetic Engineering
- Innovation and Socioeconomic Development
- Immunotherapy and Immune Responses
- Erythrocyte Function and Pathophysiology
Western University
2020-2024
Princess Margaret Cancer Centre
2024
University Health Network
2024
University of Toronto
2015-2024
London Health Sciences Centre
2022-2024
Victoria Hospital
2023-2024
Loma Linda University Health Care
2017
Queen's University
2012
The origins of cancer vaccines date back to the 1800s. Since then, there have been significant efforts generate against solid and hematologic malignancies using a variety platforms. To date, these generally met with minimal success. However, in era improved methods technological advancements, supported by compelling preclinical clinical data, wave renewed interest field offers promise discovering field-changing paradigms management established resected disease vaccines. These include novel...
The enterohemorrhagic O157 strain of Escherichia coli, which is one the most well-known bacterial pathogens, has an O-antigen repeating unit structure with sequence [-2-d-Rha4NAcα1-3-l-Fucα1-4-d-Glcβ1-3-d-GalNAcα1-]. gene cluster E. coli contains genes responsible for assembly this and includes wbdN. In spite cloning many genes, biochemical characterization been done on very few enzymes involved in synthesis. work, we expressed wbdN BL21, His-tagged protein was purified. WbdN activity...
Cutaneous squamous cell carcinoma (cSCC) is the second most common nonmelanoma skin cancer in Canada. However, few real-world reports exist on treatment of refractory locally advanced (LA) and metastatic cSCC with cemiplimab to date.
// Scott Strum 1 , 2 Mark Vincent Meghan Gipson 3 Eric McArthur and Daniel Breadner Department of Oncology, Schulich School Medicine Dentistry, London, ON, Canada London Regional Cancer Program at Health Sciences Centre, Medicine, Royal College Surgeons in Ireland, Dublin, Ireland Correspondence to: Breadner, email: daniel.breadner@lhsc.on.ca Keywords: tumor marker; biomarker; lung cancer; NSCLC; translational research Received: December 07, 2023 Accepted: February 22, 2024 Published: June...
Background. We describe a case report of 67-year-old male with PDAC who experienced an exceptional survival outcome during systemic therapy and its implications in precision medicine. hypothesize that his outcomes are attributable, part, to germline BRCA2 deletion somatic GNAS substitution. Methods. Retrospective single-patient chart review was performed at the London Regional Cancer Program, as well structured literature search spanning all years PubMed BRCA mutations pancreatic cancer....
This case report outlines a 70-year-old female patient who presented with concurrent mixed autoimmune hemolytic anemia (AIHA) and gastric adenocarcinoma. Her treatment course of these two diseases is summarized, which included supportive care, neoadjuvant chemotherapy for her adenocarcinoma, steroids, rituximab, surgical resection the tumor. approach ultimately led to stabilization AIHA primary cure solid malignancy. We briefly review both adenocarcinoma as clinical entities, propose working...
e15594 Background: Protein kinase CSNK2 (CK2) is a pleiotropic serine/threonine whose expression levels are frequently elevated in solid and hematologic malignancies. has been discovered to hold prognostic therapeutic significance across multiple cancers an excellent target for oncology research. This systematic review summarizes the current knowledge from vitro vivo studies on biology of this cancer alongside pre-clinical/clinical investigations 24 different human types. Methods: PRISMA...
e21076 Background: Conventional tumor markers are positioned to serve as a useful adjunct in lung cancer management. However, most studies this field have been specific particular disease stage or treatment regimen. Thus, the purpose of research was assess whether three minimally invasive, low-cost serum (CEA, CA19-9, and CA-125) held associations with radiographic clinical outcomes non-small cell (NSCLC) patients who received systemic therapy more comprehensive patient population. Methods:...
Presented herein is the case report of a 46-year-old male with underlying G6PD deficiency who experienced dyspnea, radiographic pulmonary infiltrates, and unexplained tachycardia while on both FOLFOX chemotherapy febrile neutropenia prophylaxis G-CSF support. The proposed mechanism illness was oxidativestress induced toxicity mediated by oxaliplatin, G-CSF, his deficiency. He treated through stopping all active agents initiating oral steroids nebulized N-acetylcystine. Within five weeks...