A5080605250- Cutaneous Melanoma Detection and Management
- Cell Adhesion Molecules Research
- Melanoma and MAPK Pathways
- Cancer Cells and Metastasis
- Immunotherapy and Immune Responses
- CAR-T cell therapy research
- Cardiac Imaging and Diagnostics
- Ferroptosis and cancer prognosis
- Telomeres, Telomerase, and Senescence
- melanin and skin pigmentation
- Cardiac, Anesthesia and Surgical Outcomes
- Cancer-related gene regulation
- Entomological Studies and Ecology
- Forest Insect Ecology and Management
- Cutaneous lymphoproliferative disorders research
- Advanced biosensing and bioanalysis techniques
- Peptidase Inhibition and Analysis
- Plant and Fungal Interactions Research
- Ultrasound in Clinical Applications
- Glycosylation and Glycoproteins Research
- Cancer Research and Treatments
- Cancer Immunotherapy and Biomarkers
- RNA modifications and cancer
- Hippo pathway signaling and YAP/TAZ
- Autophagy in Disease and Therapy
Newcastle University
2016-2021
Illinois College
2020
University of Illinois Chicago, Rockford campus
2020
James Cook University Hospital
2015-2019
Chinese University of Hong Kong
2009
University of Hong Kong
2009
A high incidence of tumor recurrence and metastasis has been reported in hepatocellular carcinoma (HCC) patients; however, the underlying molecular mechanisms are largely unknown. In present study a novel metastasis-related gene, eukaryotic initiation factor 5A2 (EIF5A2), was characterized for its role HCC mechanisms. Overexpression EIF5A2 messenger RNA (mRNA) detected 50/81 (61.7%) HCCs, which significantly higher than those nontumorous liver tissues. Compared with matched primary HCC,...
BackgroundThe updated American Joint Committee on Cancer (AJCC) staging criteria for melanoma remain unable to identify high‐risk stage I tumour subsets.
For patients with early American Joint Committee on Cancer (AJCC)-stage melanoma the combined loss of autophagy regulatory protein AMBRA1 and terminal differentiation marker loricrin in peritumoral epidermis is associated a significantly increased risk metastasis.
The eruptive disseminated form of Spitz nevi (EDSN) is the rarest variant, cosmetically disabling, and has a poorly documented natural history. We report case 4-year-old boy with more than 100 that have significantly regressed 8 years after onset. There no satisfactory treatment for EDSN. been reports supervening malignancy. Our illustrates possibility regression EDSN, corroborating long-term observation as safe acceptable management option.
Melanoma is the most deadly skin cancer, with a worldwide incidence that increases year on year. A major unmet need discovery of means through which to identify patients early stage melanoma at high risk disease progression, meaning it will spread elsewhere in body. This UK study aimed determine if loss two proteins, AMBRA1 and loricrin, (upper layer epidermis) overlying able predict are spread. Initially, levels were assessed biopsies from 79 patients. Results suggested reduction or...