A5069418958- Inflammasome and immune disorders
- interferon and immune responses
- Immune Response and Inflammation
- Phagocytosis and Immune Regulation
- Primary Care and Health Outcomes
- IL-33, ST2, and ILC Pathways
- Multiple Sclerosis Research Studies
- Syphilis Diagnosis and Treatment
- HIV, Drug Use, Sexual Risk
- Biomarkers in Disease Mechanisms
- Adolescent Sexual and Reproductive Health
- Intimate Partner and Family Violence
- Peripheral Neuropathies and Disorders
- Total Knee Arthroplasty Outcomes
- Infectious Diseases and Tuberculosis
- Otolaryngology and Infectious Diseases
- Urinary Tract Infections Management
- Viral Infections and Vectors
- Salmonella and Campylobacter epidemiology
- Hepatitis C virus research
- MicroRNA in disease regulation
- Global Health Workforce Issues
- Sex work and related issues
- NF-κB Signaling Pathways
- Kawasaki Disease and Coronary Complications
West Virginia University
2006-2025
Northwestern University
2009-2012
Cancer Genetics (United States)
2011
Robert H. Lurie Comprehensive Cancer Center of Northwestern University
2010
Activation of caspase 1 is essential for the maturation and release IL-1beta IL-18 occurs in multiprotein complexes, referred to as inflammasomes. The apoptosis-associated speck-like protein containing a recruitment domain (ASC) adaptor recruiting pro-caspase into inflammasomes, consistently gene ablation ASC abolishes activation secretion IL-18. However, distribution endogenous has not yet been examined detail. In present study, we demonstrated that localized primarily nucleus resting human...
Abstract Background The apoptotic speck-like protein containing a caspase recruitment domain (ASC) is the essential adaptor for 1 mediated interleukin (IL)-1β and IL-18 processing in inflammasomes. It bridges activated Nod like receptors (NLRs), which are family of cytosolic pattern recognition innate immune system, with 1, resulting activation subsequent substrates. Hence, macrophages from ASC deficient mice impaired their ability to produce bioactive IL-1β. Furthermore, we recently showed...
Pyrin domain (PYD) proteins have recently emerged as important signaling molecules involved in the development of innate immunity against intracellular pathogens through activation inflammatory mediator pathways. ASC is central adaptor protein, which links pathogen recognition by PYD-containing receptors, known PYD-Nod-like receptors (NLR), PAN, PYPAF, NALP, Nod, and Caterpiller proteins, to downstream effectors, including caspase-1 NF-kappaB. Activation these effectors occurs when specific...
Abstract Background West Virginia (WV) is entirely located within the Appalachian region and most of population resides in rural areas. It currently ranked 2nd nation for acute Hepatitis C infections due to opioid crisis that has devastated state. The use direct-acting antivirals (DAA) treatment revolutionized care with cure rates near 100%. However, access remains low, particularly areas such as WV. We implemented telemedicine visits our clinic address this need. Here, we describe impact...
Abstract Background Harm reduction for persons who inject drugs (PWID) has many components, including HIV testing and Pre-exposure Prophylaxis (PrEP). However, despite the increasing evidence of effectiveness, PrEP remains highly underutilized in these patients at high-risk infection subsequent transmission risk to others. Our aim is identify gaps prevention care among a hospitalized PWID population.Table 1:Demographics Clinical Characteristics Methods CHOICE+ multisite retrospective cohort...
Influenza A virus (IAV) infection remains a significant cause of morbidity and mortality worldwide. One key transcription factor that is activated upon IAV nuclear Kappa B (NF-κB). NF-κB regulation involves the inhibitor proteins beta (NFKBIB), (also known as IκB β), which form complexes with to sequester it in cytoplasm. In this study, microarray data showed differential expression several microRNAs (miRNAs) on exposure IAV. Target scan analysis revealed miR-4776, miR-4514 miR-4742...
There has been limited study of the syndemic link between HIV and intimate partner violence (IPV) among rural populations in United States. We utilized Revised Conflict Tactics Scale-2 to examine past year prevalence, type (psychological aggression, physical assault, sexual assault), impact IPV on clinical outcomes men living with Appalachia. Approximately 39% participants experienced some preceding year, 67% those individuals experiencing more than 1 IPV. 77% endorsing exposure...
Salmonella is known to cause invasive illness. However, head and neck abscesses are an unusual presentation of extra-intestinal infection with this organism. We describe a case abscess in diabetic patient. An 18 year old male was admitted increasing left sided pain swelling approximately four weeks after gastrointestinal Imaging revealed abscess. Surgical drainage undertaken. Cultures grew non-typhoid species. He treated intravenous antibiotics did well clinically. should be considered the...
The risk of postoperative complications in patients who had a positive COVID-19 test prior to total joint arthroplasty (TJA) is unknown. purpose this investigation was study the and mortality associated with recent diagnosis TJA. Patients undergoing primary revision hip arthroplasties (THAs) or knee (TKAs) were identified using National COVID Cohort Collaborative (N3C) Data Enclave. divided into COVID-19-positive group (positive polymerase chain reaction [PCR] test, clinical diagnosis,...
Abstract Background Infectious disease (ID) training is essential to the education of internal medicine residents and has traditionally occurred on inpatient rotations focused hospitalized patients. However, these offer limited experience with infectious diseases managed in outpatient setting. Furthermore, expose only one aspect multifaceted contributions ID specialists provide. Given nationwide decline providers, demonstrating diverse career paths that can stem from a potential opportunity...
Abstract Nod-like receptors (NLRs) emerged as central cytosolic pattern recognition (PRRs). However, the function of majority NLRs is currently unknown. We identified that NLRP7 functions a PRR in primary human macrophages. Activation by microbial acylated lipopeptides (acLP) causes ASC-dependent inflammasome formation high-molecular weight complex, Caspase-1 activation and maturation release interleukin (IL)-1β IL-18. Reconstitution an NLRP7/ASC/pro-Caspase-1 inflammasome, but not...
Abstract Activation of caspase-1, which is necessary for the maturation and secretion pro-inflammatory cytokines IL-1β IL-18, occurs upon assembly multi-protein complexes known as inflammasomes. Apoptosis associated speck-like protein containing a caspase recruitment domain (ASC) an adaptor protein, essential caspase-1 into However, distribution endogenous ASC has not been thoroughly examined. In current study, we used laser scanning confocal microscopy subcellular fractionation to...