A5042287581- Drug Solubulity and Delivery Systems
- Advanced Drug Delivery Systems
- Crystallization and Solubility Studies
- Advancements in Transdermal Drug Delivery
- Analytical Methods in Pharmaceuticals
- Analytical Chemistry and Chromatography
- Pharmaceutical studies and practices
- Antibiotics Pharmacokinetics and Efficacy
- Protein purification and stability
- Hormonal and reproductive studies
- Surfactants and Colloidal Systems
- Crystallography and molecular interactions
- Lipid Membrane Structure and Behavior
- Mesoporous Materials and Catalysis
- Microfluidic and Capillary Electrophoresis Applications
- Ocular Surface and Contact Lens
- Gastrointestinal motility and disorders
- Dermatology and Skin Diseases
- Innovative Microfluidic and Catalytic Techniques Innovation
- Drug Transport and Resistance Mechanisms
- Oral and gingival health research
- Reproductive tract infections research
- Clay minerals and soil interactions
- Legal and Labor Studies
- Proteoglycans and glycosaminoglycans research
University of Florence
2015-2024
Polo d’Innovazione di Genomica
2005
Topical administration of celecoxib proved to be an effective mean preventing skin cancer development and improving anticancer drugs effectiveness in tumors treatment. The aim this study was the topical formulation celecoxib, able promote drug delivery, providing its depth penetration through layers. Three kinds vesicular formulations have been investigated as carriers: liposomes containing a surfactant, or transfersomes ethosomes, suitable edge activators. Firstly, effect membrane...
The hydrochlorothiazide (HCT) low solubility and permeability give rise to limited variable bioavailability; its stability makes it difficult develop stable aqueous liquid formulations; dose the achievement of a homogeneous drug distribution very difficult. Thus, aim this study was investigate effectiveness strategy based on development nanostructured lipid carriers (NLC) as an innovative oral pediatric formulation HCT with improved therapeutic efficacy. performance various synthetic natural...
The aim of this study was the optimization solid lipid nanoparticles (SLN) and nanostructured carriers (NLC) in terms physicochemical biopharmaceutical properties, to develop effective stable aqueous liquid formulations hydrochlorothiazide, suitable for paediatric therapy, overcoming its low-solubility poor-stability problems. Based on solubility studies, Precirol® ATO5 Transcutol® HP were used as lipids, respectively. effect different surfactants, also combinations at amounts, particle...
Glyburide is a poorly water-soluble oral hypoglycemic agent, with problems of variable bioavailability and bio-inequivalence related to its poor water-solubility. This work investigated the possibility developing glyburide tablets, allowing fast, reproducible, complete drug dissolution, by using solid dispersion in polyethylene glycol. Phase-solubility studies were performed investigate drug-carrier interactions solution, whereas differential scanning calorimetry, X-ray powder diffraction,...
There is a serious need of pediatric drug formulations, whose lack causes the frequent use extemporaneous preparations obtained from adult dosage forms, with consequent safety and quality risks. Oral solutions are best choice for patients, due to administration ease dosage-adaptability, but their development challenging, particularly poorly soluble drugs. In this work, chitosan nanoparticles (CSNPs) nanostructured lipid carriers (NLCs) were developed evaluated as potential nanocarriers...
The present study was aimed at developing a tablet formulation based on an effective flurbiprofen-cyclodextrin system, able to allow rapid and complete dissolution of this practically insoluble drug. Three different cyclodextrins were evaluated: the parent β-cyclodextrin (previously found be best partner for drug among natural cyclodextrins), two amorphous, highly soluble derivatives, i.e., methyl-β-cyclodextrin hydroxyethyl-β-cyclodextrin. Equimolar drug-cyclodextrin binary systems prepared...
This work investigates the possibility of increasing dissolution properties ibuproxam (a poorly water‐soluble anti‐inflammatory drug) using hydrophilic carriers such as polyvinylpyrrolidone (PVP), polyethylene glycol (PEG), or urea, alone in combination. Phase‐solubility studies showed that carrier solubilizing power was order PEG > PVP urea and evidenced a synergistic effect drug solubility improvement when combinations. Binary ternary systems, at 20/80 20/40/40 (w/w) drug/carrier(s)...