Cardiovascular complications are the most prevalent cause of morbidity and mortality in diabetic patients. Metformin is currently first-line blood glucose-lowering agent with potential relevance to cardiovascular diseases. However, underpinning mechanisms action remain elusive. Here, we report that metformin represses cardiac apoptosis at least part through inhibition Forkhead box O1 (FoxO1) pathway. In a mouse model ischemia-reperfusion (I/R), treatment attenuated hypertrophic remodeling...

Autophagy and apoptosis are powerful regulators of multiple facets cellular metabolism homeostasis. Here, we uncover that galanin, a pleiotropic peptide, regulates cardiac autophagy deactivates apoptotic cell death through the Forkhead box protein O1 (FoxO1) pathway. In hypertrophied heart, galanin promotes metabolic shift from fatty acid (FA) to glucose oxidation preserves mitochondrial integrity. cardiomyoblasts, triggers autophagosome formation alleviates hypertrophy, death, stress....

Diabetes is a major risk factor for the development of cardiovascular disease with higher incidence myocardial infarction. This study explores role metformin, first-line antihyperglycemic agent, in postinfarction fibrotic and inflammatory remodeling mice. Three-month-old C57BI/6J mice were submitted to 30 min cardiac ischemia followed by reperfusion 14 days. Intraperitoneal treatment metformin (5 mg/kg) was initiated 15 after onset maintained Real-time PCR used determine levels COL3A1, αSMA,...

Myocardial infarction activates an intense fibro-inflammatory reaction that is essential for cardiac remodeling and heart failure (HF). Bioactive peptide galanin plays a critical role in regulating cardiovascular homeostasis; however, its specific functional relevance post-infarction reprogramming remains obscure. Here, we show coordinates the trajectory mitochondrial integrity reperfusion injury. Aberrant deposition of collagen was associated with marked increase CD68-positive macrophage...

According to the WHO, cancer is second leading cause of death globally and third most common colorectal. A significant etiological factor for carcinogenesis might be oxidative stress. Chemoprevention by consuming natural antioxidants has great perspectives in struggle control because it available affordable wide population. Studies diverse research groups discovered that grapes, as well grape-based products, are exceptional sources polyphenolic compound resveratrol, which powerful...

Acute respiratory distress syndrome (ARDS) is a critical state of the body characterized by severe hypoxemia and multiple organ failure. One organs that most often additionally affected due to systemic inflammatory reaction occurs in lungs during ARDS kidney. It known mesenchymal stem cells (MSCs) can exhibit nephroprotective effects their anti-inflammatory immunomodulatory abilities, but mechanisms such therapeutic require further elucidation. The purpose analyze macrophage polarization...

The regulatory peptide galanin is broadly distributed in the central nervous systems and peripheral tissues where it modulates numerous physiological pathological processes through binding to its three G-protein-coupled receptors, GalR1-3. However, function identity of galaninergic system heart remain unclear. Therefore, we investigated expression receptors cardiac cells found that GalR2 dominant receptor subtype adult mouse hearts, cardiomyocytes H9C2 cardiomyoblasts. In vivo, genetic...

Acute Respiratory Distress Syndrome (ARDS) is a severe clinical condition that can cause multi-organ dysfunction, including liver injury. Human umbilical cord-derived mesenchymal stromal cells (hUC-MSCs) have been shown to possess therapeutic potential for variety of diseases due their ability differentiate into various cell types and anti-inflammatory immunomodulatory properties. Purpose: To investigate the hUC-MSCs treating lipopolysaccharide (LPS)-induced injury in rats. Materials...

Lead is known to be highly toxic humans, causing various disorders infetal development. An experiment was conducted examine the effects of lead acetate on structural organization female rat ovaries. The study involved 40 non-linear rats divided into four groups: a control group, low-dose moderate-dose and high-dose group. were given solutions in varying doses for 30 days, their ovarian tissue examined using light microscopy.The results showed that increasing led morphological changes cortex...

Colon cancer is one of the leading causes cancer-related deaths worldwide. Despite growing number studies on nanoparticles different metals, there still a lack reliable information about their ability to work together as composition and antitumor effects. It has been established that regulation genes encoding proteins Bcl-2 family changes in cancer. can be potential target diagnosis have prognostic value treating with chemotherapeutic drugs. The tumor microenvironment includes myeloid...

One of the properties nanoparticles is their ability to correct manifestations oxidative stress and endotoxemia, which are critical factors in cancer development. Therefore, work aimed investigate effect usage Au/Ag/Fe on indicators endotoxemia parameters experimental colon carcinogenesis. The study was performed 90 white male rats kept standard vivarium conditions. division into groups: I – intact animals; II animals with 21 days NPs administration; III injected N,N-dimethylhydrazine...

Acute respiratory distress syndrome (ARDS) is a severe pathological condition often accompanied by kidney injury. It known that mesenchymal stem cells (MSCs) have high potential for treating various diseases due to their ability paracrinely stimulate the regeneration of damaged and tissues restore impaired organ functions. Purpose: To investigate nephroprotective effect human umbilical cord MSCs in model ARDS induced rats intranasal administration lipopolysaccharide (LPS). Materials methods:...

Colorectal cancer is the third most common in world. Despite recent therapeutic advances, it causes more than 500,000 deaths each year. The immune system plays a crucial role protecting body from cancer. However, cells are able to evade detection and destruction. For example, they can downregulate antigen expression, produce immunosuppressive molecules, or recruit that perform regulatory inhibitory functions. Understanding complex interactions between carcinogenesis for developing effective...

Background: Myocardial infarction due to ischemia-reperfusion (I/R) results in aberrant cell fate decisions leading metabolic, inflammatory and fibrotic reprogramming of the myocardium loss cardiac function. However, molecular underpinnings post-infarct-remodelled heart remain largely incomplete. The present study addresses role galanin, a pleiotropic endogenous peptide, regulation death-associated acute chronic myocardial remodeling after I/R injury.Methods: C57Bl/6J mice were subjected 24h...

Acute Respiratory Distress Syndrome (ARDS) is a life-threatening pulmonary condition characterized by severe hypoxemia and respiratory failure. Beyond its devastating impact on the lungs, ARDS often triggers systemic responses affecting vital organs throughout body. One such organ commonly affected liver, which experiences various degrees of injury during course ARDS. Pathophysiological changes in liver ARDS, particularly polarization Kupffer cells disease treatment, have drawn increasing...

The aim is to develop a method of the acellular dermal matrix manufacturing from pig’s skin dermis while preserving native structure. Materials and methods: Combination physical chemical effects on underlies in process an manufacturing. Dermal collection 1.0-1.3 mm thickness pigs under 1 year age back partially lateral parts body was carried out. 0.3-0.4 layer previously removed relevant areas with help dermatome, which physically chemically treated. maximum acellularization achieved...

The aim of this study is to evaluate the histological changes in cerebellum rat brains following chronic alcohol intoxication. Materials and Methods. We employed a classical approach for modeling intoxication by administering 40% ethanol rats (n=55) dosage 2 ml per 100 g body weight daily three months. cerebellar structure was then analyzed. Results. This investigates impact on structures cortex. cerebellum, like nervous system overall, possesses significant cellular functional reserve....

Вступ. Синдром ендогенної інтоксикації – неспецифічний стан, характерний при перебізі багатьох захворювань, зокрема онкологічних та серцево-судинних. Зважаючи на численні позитивні властивості наноматеріалів у корекції патологічних процесів, доцільно дослідити їх вплив параметри ендотоксемії здатність нанометалів працювати формі композиції. Мета дослідження встановити ефект композиції наночастинок металів Au/Ag/Fe показники індукованому канцерогенезі тлі ішемічного ураження міокарда. Методи...

МОРФОЛОГІЧНІ ЗМІНИ У ЛЕГЕНЯХ ПРИ ЕКСПЕРИМЕНТАЛЬНОМУ АНТИФОСФОЛІПІДНОМУ СИНДРОМІ ТА ЗАСТОСУВАННІ МОДУЛЯТОРІВ

COVID-19 infection, preeclampsia and gestational diabetes mellitus in pregnancy cause similar changes the placenta influence development of fetus between conception birth gestation. Proper uterine placental vascularization is essential for normal fetal development. The transplacental exchange regulated maintained by endothelium. During implantation, trophoblast differentiates into two distinct layers, inner cytotrophoblast outer syncytiotrophoblast, which are key elements human barrier....

Relevance of the research. Ovarian inflammation may be important in pathology female reproductive health and a predictor infertility.The purpose work. To assess role pro- anti-inflammatory cytokines development ovaries rats to carry out correction with inositol preparations (In); conduct retrospective analysis infertility its relationship hormone content.Material Methods. Experiments were performed on 108 white Wistar rats, which divided into 3 series: 1 – control, 3.5-4-month-old 2...

The article represents the electron microscopic study of structural components lymphoid nodules iliac lymph nodes albino male rats a reproductive age with six-week opioid nalbuphine effect on them. Nalbuphine was injected to animals daily, for six weeks, gradual weekly increase dose preparation, form model physical dependence, according Ukrainian Patent № 76564 U «Method Modeling Physical Opioid Dependence in Rats». experiments were carried out compliance bioethics. Submicroscopic changes...

According to WHO, burns rank third place among other injuries, and in some countries, the second, after traffic injuries. One of promising tools for treating burn wounds is use lyophilized xenograft skin substrate. The purpose this work was determine morphometric parameters affected by area dynamics an experimental thermal trauma case correction crushed Burning degree on shaved back guinea pig applied vapor under general anesthetic. Morphometrically, at 7, 14, 21 days experiment, thickness...