A5110231335- Paleontology and Evolutionary Biology
- Evolution and Paleontology Studies
- Ichthyology and Marine Biology
- Paleontology and Stratigraphy of Fossils
- Antibiotic Resistance in Bacteria
- Child Nutrition and Water Access
- Birth, Development, and Health
- Obesity, Physical Activity, Diet
- Cancer therapeutics and mechanisms
- Geological and Geophysical Studies
- Data-Driven Disease Surveillance
- Plant-Microbe Interactions and Immunity
- Marine animal studies overview
- Antibiotics Pharmacokinetics and Efficacy
- Bacterial biofilms and quorum sensing
- Hydrocarbon exploration and reservoir analysis
- Ubiquitin and proteasome pathways
- Amphibian and Reptile Biology
- Peptidase Inhibition and Analysis
- Microbial Natural Products and Biosynthesis
- Endoplasmic Reticulum Stress and Disease
- Cyclopropane Reaction Mechanisms
- Bacterial Genetics and Biotechnology
- Plant Pathogenic Bacteria Studies
- Evaluation Methods in Various Fields
Chinese Academy of Sciences
2014-2024
Nanjing Institute of Geology and Paleontology
2015-2024
Memorial Sloan Kettering Cancer Center
2018-2024
Kettering University
2019-2024
University of Chinese Academy of Sciences
2008-2023
First Affiliated Hospital of Soochow University
2018-2023
Soochow University
2018-2023
Nanjing University of Chinese Medicine
2023
Markey Cancer Center
2022
University of Kentucky
1995-2022
An artificial tris-catecolate siderophore with a tripodal backbone and its conjugates ampicillin amoxicillin were synthesized. Both exhibited significantly enhanced in vitro antibacterial activities against Gram-negative species compared to the parent drugs, especially Pseudomonas aeruginosa . The appeared be assimilated by an induced bacterial iron transport process as their inversely related concentration. easily synthesized has great potential for future development of various drug target...
Abstract Contrary to the fast radiation of most metazoans after end-Permian mass extinction, it is believed that early marine reptiles evolved slowly during same time interval. However, emerging discoveries Early Triassic are questioning this traditional view. Here we present an aberrant basal ichthyosauriform with a hitherto unknown body design suggests reptiles. The new species larger than coeval and has extremely small head long tail without fluke. Its heavily-built bears flattened...
The ubiquitin (Ub) and Ub-like (Ubl) protein-conjugation cascade is initiated by E1 enzymes that catalyze Ub/Ubl activation through C-terminal adenylation, thioester bond formation with an catalytic cysteine, transfer to E2 conjugating enzymes. Each of these reactions accompanied conformational changes the domain contains cysteine (Cys domain). Open conformations Cys are associated adenylation E2s, while a closed conformation pyrophosphate release formation. Several structures available for...
—Records of Early Triassic marine reptiles, when they first emerged after the end Permian mass extinction, are rare. During an excavation at Majiashan, Chaohu, Anhui Province, a new sauropterygian specimen was found co-occurring with ichthyopterygian Chaohusaurus from Upper Member Nanlinghu Formation, Olenekian (Spathian, Triassic) age, for which taxon, Majiashanosaurus discocoracoidis, gen. et sp. nov., is erected. This skeleton exposed in ventral view, last three cervical vertebrae...
During the last decade, abundant ichthyopterygian material has been found from Triassic of South China as well Upper Jurassic and Lower Cretaceous Europe America, significantly expanding our knowledge diversity through Mesozoic. Previous phylogenetic hypotheses group no longer account for these extensive additions, necessitating a new framework entire Ichthyopterygia to enable evolutionary studies group. We present here comprehensive hypothesis based on cladistic analysis 163 characters...
The Gram-negative bacterial pathogen Pseudomonas aeruginosa uses three interconnected intercellular signaling systems regulated by the transcription factors LasR, RhlR, and MvfR (PqsR), which mediate cell–cell communication via small-molecule natural products control production of a variety virulence factors. system is activated controls biosynthesis quinolone quorum sensing HHQ PQS. A key step in these quinolones catalyzed anthranilyl-CoA synthetase PqsA. To develop inhibitors PqsA as novel...
Abstract Transthiolation (also known as transthioesterification) reactions are used in the biosynthesis of acetyl coenzyme A, fatty acids and polyketides, for post-translational modification by ubiquitin (Ub) ubiquitin-like (Ubl) proteins 1–3 . For Ub pathway, E1 enzymes catalyse transthiolation from an E1~Ub thioester to E2~Ub thioester. is also required transfer HECT (homologous E6AP C terminus) RBR (ring-between-ring) E3 ligases form E3~Ub thioesters 4–6 How isoenergetic bonds driven...
Mesozoic marine reptiles and modern mammals are often considered ecological analogs, but the extent of their similarity is largely unknown. Particularly important presence/absence deep-diving suction feeders among because this would indicate establishment mesopelagic cephalopod fish communities in Mesozoic. A recent study suggested that diverse feeders, resembling extant beaked whales, evolved ichthyosaurs Triassic. However, hypothesis has not been tested quantitatively. We examined four...
The fossil record of a major clade often starts after mass extinction even though evolutionary rates, molecular or morphological, suggest its pre-extinction emergence (e.g. squamates, placentals and teleosts). discrepancy is larger for older clades, the presence time-scale-dependent methodological bias has been suggested, yet it difficult to avoid using Bayesian phylogenetic methods. This paradox raises question whether ecological vacancies, such as those extinctions, prompt radiations. We...
Several N-acyl ciprofloxacin quinone derivatives based on a trimethyl lock structure were synthesized, and their in vitro antibacterial activity against panel of clinically relevant bacteria was evaluated. A few new analogues displayed enhanced Gram-positive species compared to the parent drug. Additionally, studies 8-Cip, which most potent compound tested, indicate that it may act through dual-action mechanism.
Syringolides are water-soluble, low-molecular-weight elicitors that trigger defense responses in soybean cultivars carrying the Rpg4 disease-resistance gene but not rpg4 cultivars. 125I-syringolide 1 previously was shown to bind a soluble protein(s) extracts from leaves. A 34-kDa protein accounted for binding activity isolated with syringolide affinity-gel column. Partial sequences of internal peptides were identical P34, described seed allergen. In seeds, P34 is processed 46-kDa precursor...
Abstract The Smithian–Spathian boundary (SSB) crisis played a prominent role in resetting the evolution and diversity of nekton (ammonoids conodonts) during Early Triassic recovery. late Smithian nektonic culminated at SSB, ca. 2.7 Myr after Permian–Triassic mass extinction. An accurate high-resolution biochronological frame is needed for establishing patterns extinction re-diversification this crisis. Here, we propose new conodonts that based on Unitary Associations Method (UAM). In time...
Berberine the main antibacterial substance in rhizome of Coptis chinensis Franch, is used as an antimicrobial agent for a long time. This study was carried out to investigate potential berberine alone or combination with enrofloxacin against six common fish pathogens use disease management aquaculture. The minimum inhibitory concentrations (MICs) hydrochloride Aeromonas hydrophila, Pseudomonas fluorescens, Vibrio vulnificus, Edwardsiella ictaluri, Escherichia coli and Streptococcus...
Air-breathing marine predators have been essential components of the ecosystem since Triassic. Many them are considered apex but without direct evidence-dietary inferences usually based on circumstantial evidence, such as tooth shape. Here we report a fossil that likely represents oldest evidence for predation megafauna, i.e., animals equal to or larger than humans, by tetrapods-a thalattosaur (∼4 m in total length) stomach Middle Triassic ichthyosaur (∼5 m). The predator has grasping teeth...