A5052948945- Cancer Genomics and Diagnostics
- Prostate Cancer Treatment and Research
- Receptor Mechanisms and Signaling
- interferon and immune responses
- Viral Infections and Immunology Research
- RNA regulation and disease
Indian Institute of Science Bangalore
2022-2023
Advanced prostate cancer patients initially respond to hormone therapy, be it in the form of androgen deprivation therapy or second-generation therapies, such as abiraterone acetate enzalutamide. However, most men with eventually develop resistance. This resistance can arise through multiple mechanisms, genetic mutations, epigenetic non-genetic pathways, lineage plasticity along epithelial-mesenchymal neuroendocrine-like axes. These mechanisms often co-exist within a single patient's tumor...
Abstract Advanced prostate cancer patients initially respond to hormone therapy, be it in the form of androgen deprivation therapy or second-generation therapies, such as abiraterone acetate enzalutamide. However, most men with eventually develop resistance. This resistance emerges several ways, through genetic mutations, epigenetic mechanisms, non-genetic pathways, lineage plasticity along epithelial-mesenchymal neuroendocrine-like axes. These mechanisms often co-exist within a single...