A5089520035- Mitochondrial Function and Pathology
- Child and Animal Learning Development
- Cell death mechanisms and regulation
- Cognitive Abilities and Testing
- Neuroscience and Neuropharmacology Research
- Cerebrovascular and Carotid Artery Diseases
- Eating Disorders and Behaviors
- Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes
- Advanced MRI Techniques and Applications
- Adipose Tissue and Metabolism
- Early Childhood Education and Development
- Mental Health Research Topics
- Functional Brain Connectivity Studies
University College London
2023
Max Planck Institute for Human Development
2023
Roslin Institute
2021-2023
University of Edinburgh
2021-2023
University of Reading
2015-2017
Age is the main risk factor for development of neurodegenerative diseases. In aged brain, axonal degeneration an early pathological event, preceding neuronal dysfunction, and cognitive disabilities in humans, primates, rodents, invertebrates. Necroptosis mediates injured axons, but whether necroptosis triggers neurodegeneration impairment along aging unknown. Here, we show that loss necroptotic effector Mlkl was sufficient to delay age-associated neuroinflammation, protecting against...
Cortical acetylcholine is involved in key cognitive processes such as visuospatial attention. Dysfunction the cholinergic system has been described a number of neuropsychiatric disorders. Levels brain can be pharmacologically manipulated, but it not possible to directly measure vivo humans. However, parts its biochemical cascade neural tissue, choline, measured using magnetic resonance spectroscopy (MRS). There evidence that levels choline may an indirect proportional availability tissue. In...
BackgroundAnhedonia, the loss of pleasure in usually enjoyable activities, is a central feature major depressive disorder (MDD). The aim present study was to examine whether young people at familial risk depression display signs anticipatory, motivational or consummatory anhedonia, which would indicate that these deficits may be trait markers for MDD.MethodsThe completed by 22 participants with family history (FH+) and 21 controls (HC). Anticipatory anhedonia assessed asking rate their...
Childhood cognitive control is an important predictor for positive development, yet interventions seeking to improve it have provided mixed results. This partly due lack of clarity surrounding mechanisms control, notably the role inhibition and context monitoring. Here we use a randomized controlled trial causally test contributions monitoring in childhood. Sixty children aged 6 9-years were assigned three groups training either inhibition, group or response speed using gamified, highly...
Abstract Age is the main risk factor for development of neurodegenerative diseases. In aged brain, axonal degeneration an early pathological event, preceding neuronal dysfunction, and cognitive disabilities in humans, primates, rodents, invertebrates. Necroptosis mediates injured axons, but whether necroptosis triggers neurodegeneration impairment along aging unknown. Here we show that loss necroptotic effector Mlkl was sufficient to delay age-associated neuroinflammation, protecting against...
Childhood cognitive control is an important predictor for positive development, yet interventions seeking to improve it have provided mixed results. This partly due lack of clarity surrounding mechanisms control, notably the role inhibition and context monitoring. Here we use a randomized controlled trial causally test contributions monitoring in childhood. Sixty children aged 6 9-years were assigned three groups training either inhibition, group or response speed using gamified, highly...