A5068522704- Inflammatory mediators and NSAID effects
- Synthesis and biological activity
- Nitric Oxide and Endothelin Effects
- Peroxisome Proliferator-Activated Receptors
- Receptor Mechanisms and Signaling
- Adipose Tissue and Metabolism
- Venous Thromboembolism Diagnosis and Management
- Advanced Proteomics Techniques and Applications
- Toxin Mechanisms and Immunotoxins
- Synthesis and Reactions of Organic Compounds
- Eicosanoids and Hypertension Pharmacology
- Bee Products Chemical Analysis
- Click Chemistry and Applications
- Atherosclerosis and Cardiovascular Diseases
- Atrial Fibrillation Management and Outcomes
- Antiplatelet Therapy and Cardiovascular Diseases
- Advanced Glycation End Products research
- Ubiquitin and proteasome pathways
- Genomics, phytochemicals, and oxidative stress
- Complementary and Alternative Medicine Studies
- Synthesis and Biological Evaluation
- Protein Degradation and Inhibitors
- Connexins and lens biology
- Macrophage Migration Inhibitory Factor
- Enzyme function and inhibition
American University of Beirut
2017-2021
Alexandria University
2019
University of Alberta
2019
Beirut Arab University
2017
Pharmaceutical Biotechnology (Czechia)
2017
Endothelial dysfunction is a hallmark of diabetic vasculopathies. Although hyperglycemia believed to be the culprit causing endothelial damage, mechanism underlying early insult in prediabetes remains obscure. We used nonobese high-calorie (HC)-fed rat model with hyperinsulinemia, hypercholesterolemia, and delayed development unravel this mechanism. Compared aortic rings from control rats, HC-fed displayed attenuated acetylcholine-mediated relaxation. While sensitive nitric oxide synthase...
Emerging evidence supports an intertwining framework for the involvement of different inflammatory pathways in a common pathological background number disorders. Of importance are involving arachidonic acid metabolism by cyclooxygenase-2 (COX-2) and 15-lipoxygenase (15-LOX). Both enzyme activities their products implicated range pathophysiological processes encompassing metabolic impairment leading to adipose inflammation subsequent vascular neurological disorders, addition various pro-...
Introduction: One of the common syndromes that affect humanity is neuropathic pain (NP), yet poorly understood with no efficient treatment till now. Consequently, it extremely crucial to seek further evidence for accurate diagnosis and optimum treatment. The aim this work summarize findings related in terms etiology, types, diagnosis, current future management prospective, identify gaps therapy. Methods: A literature investigation was carried out by analyzing classical peer reviewed papers...
The work reported herein describes the synthesis of a new series anti-inflammatory pyrazolyl thiazolones. In addition to COX-2/15-LOX inhibition, these hybrids exerted their actions through novel mechanisms. most active compounds possessed COX-2 inhibitory activities comparable celecoxib (IC50 values 0.09-0.14 µM) with significant 15-LOX (IC50s 1.96 3.52 µM). Upon investigation in vivo and ulcerogenic profiles, showed activity patterns equivalent or more superior diclofenac and/or celecoxib....
Endothelial dysfunction is a common occurrence in diabetes, secondary to hyperglycemia. However, little known about the mechanism underlying early endothelial damage occurring course of diabetes development prior impaired glycemic control. We used high‐calorie (HC) diet rat model with delayed hyperglycemia address this question. Aortic rings from HC rats exhibited endothelium‐dependent relaxation phenylephrine (PE)‐induced tone acetylcholine (ACh), where higher concentrations ACh caused an...
Inflammation is associated with different clinical conditions including rheumatoid disorders and multiple sclerosis. Recently, inflammation has been linked to metabolic diseases, such as diabetes. In addition their antidiabetic effect, thiazolidinediones (TZDs), through PPARγ transactivation, are also known negatively control transcriptional pathways that critical for the synthesis of pro‐inflammatory molecules. Moreover, selective COX‐2 inhibitors serve effective anti‐inflammatory agents...