A5050540021- Drug-Induced Hepatotoxicity and Protection
- Potato Plant Research
- Nigella sativa pharmacological applications
- Heavy Metal Exposure and Toxicity
- Trace Elements in Health
- Moringa oleifera research and applications
- Drug Transport and Resistance Mechanisms
- Natural Antidiabetic Agents Studies
- Boron and Carbon Nanomaterials Research
- Electromagnetic Fields and Biological Effects
- Vanadium and Halogenation Chemistry
- Synthesis and biological activity
- Heme Oxygenase-1 and Carbon Monoxide
- Metal and Thin Film Mechanics
- Chemotherapy-induced organ toxicity mitigation
- Pharmacological Effects and Toxicity Studies
- Pharmacological Effects of Natural Compounds
- Synthesis and Characterization of Heterocyclic Compounds
- Sesame and Sesamin Research
- Bee Products Chemical Analysis
- Essential Oils and Antimicrobial Activity
- Medicinal Plants and Neuroprotection
- Nanoparticles: synthesis and applications
- Pesticide Exposure and Toxicity
- Selenium in Biological Systems
Jiwaji University
2015-2024
Venus Remedies (India)
2009
Brigham and Women's Hospital
2006
Indian Institute of Technology Delhi
1995-1996
Merck (Japan)
1994
United States Military Academy
1994
This study aimed to treat hepatocellular ailments with biologically prepared silver nanoparticle (AgNPs). AgNPs were formulated using Morus alba leaf extract and their synthesis characterization determined by UV-visible spectroscopy, Transmission Electron Microscope (TEM), Scanning microscope (SEM), X-ray diffraction (XRD), Fourier transform infrared spectroscopy (FT-IR) Zeta analysis. In vitro studies on HepG2 cell lines for cytotoxic effect in vivo a rat model hepatoprotective carried out...
Abstract Oxidative injury is concerned with the pathogenesis of several liver injuries, including those from acute failure to cirrhosis. This study was designed explore antioxidant activity Bacopa monnieri (BM) on Aflatoxin B1 (AFB1) induced oxidative damage in Wistar albino rats. treatment (200 μg/kg/day, p.o.) for 28 days by a significant alteration serum function test marker enzymes (AST, ALT, ALP, LDH, albumin and bilirubin), inflammatory cytokines (IL-6, IL-10 TNF-α), thiobarbituric...
Rosa damascena (RD) is a widely cultivated ornamental plant. It acts as an astringent, aperients, carminative, and refrigerant used in respiratory disorders, tonsillitis, eye migraines, gynecological menopausal symptoms. The aim of this study to investigate the hepatoprotective activity aqueous extract RD flowers at different oral dose levels (250, 500, 1000 mg/kg body weight) on acetaminophen (2 g/kg N-acetyl-p-aminophenol [APAP])−induced toxicity rats. APAP administration altered various...
Abstract Acrylamide (AA) is a chemical agent mostly used in the manufacture of polymers and copolymers. Recently, it has gained attention because its production food items prepared at high‐temperature (>120°C) processes, such as frying, toasting, cooking, roasting or baking high carbohydrate items. As per higher exposure AA, appropriate identification toxic effect necessary. Hepatotoxicity, nephrotoxicity, neurotoxicity, reproductive toxicity, immunotoxicity AA have been observed several...
The study investigates the effects of aqueous extract Bougainvillea spectabilis leaves on blood glucose, glycosylated hemoglobin, lipid profile, oxidative stress, and DNA damage, if any, as well liver kidney functions in streptozotocin-induced diabetes Wistar rats. Daily administration B for 28 days resulted significant reduction hyperglycemia hyperlipidemia evident from restoration relevant biochemical markers following administration. also exhibited antioxidant activity evidenced enzymatic...
Acrylamide is a well-known neurotoxicant and carcinogen. Apart from industrial exposure, acrylamide also found in different food products. The present study deals with vivo experiment to test the protective effect of rutin against induced toxicity rats. was carried out on female rats exposure at dose 38.27 mg/kg body weight, orally for 10 days followed by therapy (05, 10, 20 40 orally), three consecutive days. All animals were sacrificed after 24 h last treatment various biochemical...
Aim: The curative effect of emodin (1,3,8‐trihydroxy‐6‐methyl anthraquinone), an active compound the plant species Ventilago maderaspatana Gaertn, was evaluated against carbon tetrachloride (CCl 4 ) induced hepatic cytochrome P450 (CYP) enzymatic and ultrastructural alterations in rats. Methods: Female rats were administered CCl (1.5 mL/kg, ip) followed by varying doses (20, 30 40 mg/kg, oral po) after 24 h administration. Animals euthanized last administration to determine liver function...
Abstract Present study was planned to investigate the ameliorative effect of silver nanoparticles (AgNPs) on acetaminophen-induced nephrotoxicity. Our results demonstrate that therapy AgNPs at three different doses (50, 100 and 150 μg/kg once only) prevented acetaminophen (2 g/kg induced acute renal toxicity. treated animals also show less intensity in histological alterations kidneys corroborating analysis serum urea creatinine. In addition, oxidative stress, which confirmed by alleviated...
Background: Ginger is widely used as a medicine in the Ayurvedic system. It contains active compound gingerol, which scavenges free radicals. Prolonged intake of aluminum (Al) drinking water and from other sources may lead to neurological, renal, hepatic dysfunction. Objective: The present study was designed evaluate protective effect an principal ginger against Al (NO3)3 -induced toxicity rats. Methods: at 32.5 mg/kg body weight administered female albino rats intraperitoneally once only,...
The study aimed to discover a link between the liver and brain's functional status due frequency dependent-radiofrequency electromagnetic radiation (RF-EMR). Forty Wistar rats were randomly classified as control (sham-exposed) EMR exposed groups. Animals 900, 1800, 2100 MHz with specific absorption rate (SAR) 0.434 (W/Kg), 0.433 0.453 (W/Kg) respectively. Animal exposure was limited at 1 h/day, 5 days/week for month restricted power density (900 MHz- 11.638 µW/m2, 1800- 11.438 µW/m2...