A5006324485- Cancer-related molecular mechanisms research
- RNA modifications and cancer
- MicroRNA in disease regulation
- Circular RNAs in diseases
Hunan University
2018-2020
In recent years, it has been increasingly clear that long noncoding RNAs (lncRNAs) play critical roles in many biological processes associated with human diseases. Inferring potential lncRNA-disease associations is essential to reveal the secrets behind diseases, develop novel drugs, and optimize personalized treatments. However, experiments validate are very time-consuming costly. Thus, effective computational models. this study, we have proposed a method called BPLLDA predict based on...
In recent years, more and studies have shown that microRNAs (miRNAs) play a key role in many important biological processes. Dysregulation of miRNAs can lead to variety diseases like cancers, thus predicting potential miRNA-disease associations is for understanding drug development disease pathogenesis, diagnosis treatment. It known experimental methods validate typically involve miRNA knockout or knockdown, which time labor-intensive. As result, computational models been developed predict...
In recent years, it has been increasingly clear that long non-coding RNAs (lncRNAs) are able to regulate their target genes at multi-levels, including transcriptional level, translational etc and play key regulatory roles in many important biological processes, such as cell differentiation, chromatin remodeling more. Inferring potential lncRNA-disease associations is essential reveal the secrets behind diseases, develop novel drugs, optimize personalized treatments. However, experiments...