A5080348643- Nutritional Studies and Diet
- Diet and metabolism studies
- Neuroinflammation and Neurodegeneration Mechanisms
- Neuroscience and Neuropharmacology Research
- Nutrition, Genetics, and Disease
- Adipokines, Inflammation, and Metabolic Diseases
- Fungal Biology and Applications
- Gut microbiota and health
- Birth, Development, and Health
- Effects and risks of endocrine disrupting chemicals
- Natural Antidiabetic Agents Studies
- Agriculture Sustainability and Environmental Impact
- Phytochemicals and Antioxidant Activities
- Medicinal Plants and Bioactive Compounds
- Biochemical Analysis and Sensing Techniques
- Ginkgo biloba and Cashew Applications
- Folate and B Vitamins Research
- Dietary Effects on Health
- Barrier Structure and Function Studies
- Hops Chemistry and Applications
- Consumer Attitudes and Food Labeling
- Healthcare Regulation
- Cardiac electrophysiology and arrhythmias
- Medicinal Plants and Neuroprotection
- Pesticide Residue Analysis and Safety
Polytechnic Institute of Bragança
2022-2025
Centre for Health Technology and Services Research
2015-2018
Universidade do Porto
2010-2017
University of Algarve
2017
Fundação Faculdade de Medicina
2015
University of Reading
2015
ThyssenKrupp (Brazil)
2014
In the past decades, obesity and associated metabolic complications have reached epidemic proportions. For study of these pathologies, a number animal models been developed. However, direct comparison between Wistar Sprague-Dawley (SD) Rat as high-fat (HF) diet-induced has not adequately evaluated so far. SD rats were assigned for 2 experimental groups 17 weeks: standard (St) diet groups. To assess some features syndrome, oral glucose tolerance tests, systolic blood pressure measurements...
High-fat (HF) diets are thought to disrupt the profile of gut microbiota in a manner that may contribute neuroinflammation and neurobehavioral changes observed obesity. Accordingly, we hypothesize by preventing HF-diet induced dysbiosis it is possible prevent consequent neurological disorders. Anthocyanins flavonoids found berries exhibit anti-neuroinflammatory properties context Here, demonstrate blackberry anthocyanin-rich extract (BE) can modulate composition counteract some features...
For many years mushrooms have been used empirically in traditional medicine to treat several diseases. Study of the maitake mushroom, with its immunomodulatory and antitumoral properties, has led isolation bioactive compounds. One these, D fraction, is known reduce tumor cell viability. This study examined effect isolated fraction on viability apoptosis human breast cancer cells (MCF7). These were treated (D fraction) extract at 18 μg/mL, 36 91 183 or 367 μg/mL left untreated (control) for...
The aim of this study was to understand whether high folic acid (HFA) exposure during the perigestational period induces metabolic dysfunction in offspring, later life. To do this, female Sprague-Dawley rats (G0) were administered a dose (FA) recommended for pregnancy (control, C, 2 mg FA/kg diet, n=5) or FA (HFA, 40 n=5). Supplementation began at mating and lasted throughout lactation. Body weight food fluid intake monitored G0 their offspring (G1) till G1 13 months age. Metabolic blood...
Abstract Endocrine-disrupting chemicals such as p , ’-dichlorodiphenyldichloroethylene ( ’-DDE), are bioaccumulated in the adipose tissue (AT) and have been implicated obesity diabetes epidemic. Thus, it is hypothesized that ’-DDE exposure could aggravate harm of an obesogenic context. We explored effects 12 weeks male Wistar rats’ metabolism AT biology, assessing a range metabolic, biochemical histological parameters. -treatment exacerbated several metabolic syndrome-accompanying features...
Abstract Flavonoids are a key class of polyphenols, i.e., phytochemical compounds present in foods and beverages, which have been described as having health benefits preventing several chronic diseases. Estimating flavonoid intake has already conducted countries but yet to be performed Portugal. This study included 5,005 participants aged 3-84 years aimed estimate dietary the Portuguese population, using data from National Food Physical Activity Survey 2015-2016, providing information on...
We aimed to explore the potential benefits of long-term supplementation with blackberry anthocyanin extract in context a standard or high-fat diet.
Some chemicals used in consumer products or manufacturing (eg, plastics, pesticides) have estrogenic activities; these xenoestrogens (XEs) may affect immune responses and recently emerged as a new risk factors for obesity cardiovascular disease. However, the extent impact on health of chronic exposure general population to XEs are still unknown.The objective study was investigate levels plasma adipose tissue (AT) depots sample pre- postmenopausal obese women undergoing bariatric surgery...
ABSTRACT Scientific evidence has shown an association between organochlorine compounds (OCC) exposure and human health hazards. Concerning this, OCC detection in adipose samples to be considered a public priority. This study evaluated the efficacy of various solid‐phase extraction (SPE) cleanup methods for determination tissue. Octadecylsilyl endcapped (C 18 ‐E), benzenesulfonic acid modified silica cation exchanger (SA), poly(styrene‐divinylbenzene (EN) EN/RP SPE sorbents were evaluated....
Scope The present study aimed to characterize and evaluate flavonoids effects on organic cation uptake in neuronal cells. Methods results Uptake experiments were conducted using radiolabeled methyl‐4‐phenylpyridinuim ([ 3 H]‐MPP + ), human dopaminergic cells, SH‐SY5Y. Catechin did not alter [ uptake, however its metabolite 4’‐methyl‐catechin decreased it by almost 50%. Epicatechin methylated metabolites also uptake. Interestingly, the quercetin flavonol conjugated with glucuronic acid, as...
This study investigates the effect of olive leaf tea (OLT) on postprandial glycemia in healthy volunteers when ingested with a high-carbohydrate meal, compared placebo (CON). Healthy adults participated double-blind, randomized, placebo-controlled, and cross-over design trial receiving high-rich carbohydrate meal either 250 mL OLT or CON at two different times after washout period. The sequence order was randomized ratio 1:1. Capillary blood glucose measured 2 h period ingestion. Eighteen...