A5090511137- Phytochemicals and Antioxidant Activities
- Genetics, Aging, and Longevity in Model Organisms
- Tea Polyphenols and Effects
- Fermentation and Sensory Analysis
- Horticultural and Viticultural Research
- Antioxidant Activity and Oxidative Stress
- Natural Antidiabetic Agents Studies
- Circadian rhythm and melatonin
- Nutritional Studies and Diet
- Free Radicals and Antioxidants
- Biochemical Analysis and Sensing Techniques
- Nutrition and Health in Aging
- Essential Oils and Antimicrobial Activity
- Coenzyme Q10 studies and effects
- Chromatography in Natural Products
- Alcohol Consumption and Health Effects
- Genomics, phytochemicals, and oxidative stress
- Body Composition Measurement Techniques
- Dementia and Cognitive Impairment Research
- Aging, Health, and Disability
- Spaceflight effects on biology
- Plant biochemistry and biosynthesis
- Bee Products Chemical Analysis
- Food Quality and Safety Studies
- Neuroscience and Neuropharmacology Research
Universidad de Salamanca
2016-2025
Ministry of Economy, Industry and Competitiveness
2025
Instituto de Investigación Biomédica de Salamanca
2022-2025
Newcastle University
2010
Instituto de Gestión de la Innovación y del Conocimiento
2010
University of Leeds
2010
Cambridge University Press
2010
New York University Press
2010
University of Southampton
2010
Université Sorbonne Paris Nord
2010
The effect of polyphenols, phenolic acids and tannins (PPTs) from strawberry apple on uptake apical to basolateral transport glucose was investigated using Caco-2 intestinal cell monolayers. Substantial inhibition both observed by extracts apple. Using sodium-containing (glucose transporters SGLT1 GLUT2 active) sodium-free (only conditions, we show that the greater than SGLT1. were analyzed some constituent PPTs also tested. Quercetin-3-O-rhamnoside (IC₅₀ =31 μM), phloridzin (IC₅₀=146...
Chronic oral quercetin reduces blood pressure and restores endothelial dysfunction in hypertensive animals. However, (aglycone) is usually not present plasma, because it rapidly metabolized into conjugated, mostly inactive, metabolites. The aim of the study to analyze whether deconjugation these metabolites involved lowering effect quercetin.We have analyzed effects on vascular function vitro conjugated (quercetin-3-glucuronide, Q3GA; isorhamnetin-3-glucuronide, I3GA; quercetin-3'-sulfate,...
Abstract Scope: The dietary flavonoid quercetin exerts protective cardiovascular effects. Because is rapidly metabolized into less active or inactive glucuronidated metabolites and the plasma concentrations of free are very low, a huge amount scientific data generated along decades with unconjugated compounds in vitro has been questioned. We aimed to determine whether can deconjugate situ deconjugation leads biological effect. Methods results: Quercetin quercetin‐3‐ O ‐glucuronide (Q3GA)...
The effectiveness of seven phenolic compounds (catechin, epicatechin, procyanidin B2, caffeic acid, p-coumaric myricitrin, and quercitrin) as copigments malvidin 3-glucoside, the major anthocyanin in red wines from Vitis vinifera, using a copigment/pigment molar ratio 1:1 was assayed model wine solutions under same conditions (pH=3.6, 12% ethanol). stability copigment-pigment complexes formed studied during storage period 60 days at 25 degrees C. Tristimulus colorimetry applied for color...
Dietary flavonoids have been associated with a lower incidence of some chronic diseases. However, the mechanisms behind in vivo biological activity are still mostly unknown. Flavonoids metabolized human body to conjugated forms (methylated, sulphated and glucuronidated derivatives) that should play role flavonoid activity. In this study, anti-proliferative effects metabolites quercetin (epi)catechin, major diet, evaluated against three different cancer cell lines from breast (MCF-7), colon...
Micro-oxygenation is usually applied to red wines as a cheaper alternative oak aging. It has been suggested, however, that micro-oxygenation can also be used complement aging in order improve the quality of very astringent and herbaceous wines. In this paper we study how applying technique before affects composition When prior aging, have slightly less intense color significantly higher levels combined free anthocyanins ethyl-bridged anthocyanin−flavanol pigments. On other hand, no...
Quercetin is a major flavonoid in the human diet and most commonly used studies of biological activity. Most knowledge about its effects has originated from vitro while vivo data are scarce. mostly occurs foodstuffs as glycosides that deglycosylated during absorption further submitted to different conjugation reactions. Methylation isorhamnetin (quercetin 3′-O-methylether) or tamarixetin 4′-O-methylether) seems be an important process quercetin metabolism. In this work, 3′- 4′-O-methylated...
The nematode Caenorhabditis elegans has been used to examine the influence of epicatechin (EC), an abundant flavonoid in human diet, some stress biomarkers (ROS production, lipid peroxidation and protein carbonylation). Furthermore, ability EC modulate expression key genes insulin/IGF-1 signaling pathway (IIS), involved longevity oxidative or heat shock response, also explored. final aim was contribute elucidation mechanisms biological effects flavonoids. results showed that EC-treated...