A5090925848- Hematopoietic Stem Cell Transplantation
- Acute Lymphoblastic Leukemia research
- Autoimmune and Inflammatory Disorders Research
- Parvovirus B19 Infection Studies
- Acute Myeloid Leukemia Research
- Immune Cell Function and Interaction
- Virus-based gene therapy research
- Blood disorders and treatments
- Anorectal Disease Treatments and Outcomes
- Colorectal and Anal Carcinomas
- Immunodeficiency and Autoimmune Disorders
- Childhood Cancer Survivors' Quality of Life
- Viral-associated cancers and disorders
- Chronic Myeloid Leukemia Treatments
- Platelet Disorders and Treatments
- CAR-T cell therapy research
- Family and Disability Support Research
- Diverticular Disease and Complications
- Hematological disorders and diagnostics
- Cellular Mechanics and Interactions
- Viral Infections and Immunology Research
- Soft tissue tumor case studies
- Eosinophilic Disorders and Syndromes
- Blood groups and transfusion
- Amoebic Infections and Treatments
Leeds Teaching Hospitals NHS Trust
1993-2023
Leeds General Infirmary
1993-2023
Sheffield Children's NHS Foundation Trust
2020-2023
Hospital for Sick Children
2016-2020
University of Toronto
2017-2018
Izaak Walton Killam Health Centre
2017
SickKids Foundation
2016-2017
Maternity and Children's Hospital
2015
University of Leeds
1993
Abstract Stem cell transplant (SCT) outcomes in high-risk and relapsed/refractory (R/R) pediatric acute myeloid leukemia (AML) myelodysplastic syndrome (MDS) have been historically poor. Cord blood (CB) allows T-cell replete CB (TRCB), enabling enhanced graft-versus-leukemia. We consecutively collected data from 367 patients undergoing TRCB (112 patients) or other source (255 SCT for AML/MDS the United Kingdom Ireland between January 2014 December 2021. Data were about patient’s...
Advanced myelodysplastic syndrome harbors a high risk of progression to acute myeloid leukemia and poor prognosis. In children, there is no established treatment prevent or delay prior hematopoietic stem cell transplantation. Azacitidine hypomethylating agent, which was shown slow in adults with syndrome. There little data on the efficacy azacitidine children. We reviewed 22 pediatric patients advanced from single center, diagnosed between January 2000 December 2015. Of those, eight received...
Secondary failure of platelet engraftment occurs in 20% patients undergoing allogeneic HSCT and is associated with poor outcome. Currently, there are no guidelines for treatment late thrombocytopenia transfusion the mainstay treatment. Here, we describe use Eltrombopag to treat secondary recovery following a child severe aplastic anemia. resulted count need support reported side effects. may be used successfully children post-HSCT SAA.
To investigate levels of quality life (QOL) among thalassemia patients at the Hereditary Blood Disorders Center in Al-Madinah Al-Munawarah, Kingdom Saudi Arabia.A cross-sectional study was performed on 43 transfusion dependent compared with normal subjects, as a control, using World Health Organization Quality Of Life - Brief questionnaire between May 2012 and September Center, Maternity Children Hospital Arabia.Forty-three were examined, 23 males 20 females, peers (control group), 24 19...
Human adenovirus (HAdV) is recognized as a serious pathogen after allogeneic hematopoietic stem cell transplantation (HSCT), causing morbidity and mortality. Currently, there no universal agreement regarding routine HAdV surveillance HSCT. We assessed the impact of weekly monitoring by polymerase chain reaction (PCR) on viremia rates risk factors that influence survival. Three-hundred fifty-six pediatric HSCT were done between 2007 2015. Until July 2011, testing was performed based clinical...
Smoking has been associated, on epidemiologic grounds, with an increased risk of cervical neoplasia. We have investigated this association, using laboratory-based methods. A 32P post-labeling assay was performed 97 biopsies to detect and measure DNA adducts (additional products formed by the covalent binding potential chemical carcinogens nuclear DNA). The specimens were taken from both normal cervices as well histologically regions invasive intraepithelial detailed smoking history obtained...
EBV-related PTLD developing after HSCT is a potentially life-threatening disease. HLH uncommon allogeneic HSCT. Data on outcome of patients with and concomitant are limited. In this retrospective study, we collected demographic, clinical, laboratory, data for 408 who underwent from 2006 to 2015. Graft source included CB (n = 135; 33.1%), PBSCs 34; 8.3%), BM 239; 58.6%). Eight out (2%) developed EBV-PTLD median age at 5.9 years (range: 2.3-17.3). All eight received ATG as part the...
Among 235 children with acute myeloid leukemia, 17 experienced 19 perianal infections. 12 episodes definite abscess, 75% were severely neutropenic. Sixteen diagnostic imaging evaluations performed; yield was similar between computerized tomography of pelvis (5 10) and ultrasound (3 5). Consistent management approaches to infection should be developed.
Summary Progressive cytopenia is a serious complication among paediatric patients with inherited bone marrow failure syndromes (IBMFS). Androgens have been used to improve blood counts in different conditions. Little known about efficacy and toxicity new androgens (i.e., danazol) types of IBMFS. We identified 29 from the Canadian Inherited Marrow Failure Registry, who received oxymetholone or danazol. Sixteen (55%) had haematological response including unclassified IBMFS (45%). Danazol...
Abstract Background Hemophagocytic lymphohistiocytosis (HLH), a rare hyperinflammatory immuneregulatory disorder, is challenge in hematopoietic stem cell transplantation (HSCT) because of the high rate mixed chimerism, relapse, and graft failure (GF) unless intensive myeloablative regimens are used. However, historically conventional (conv MA) associated with toxicity mortality. Procedure We retrospectively compared transplant outcomes between three preparative varying intensities: Conv MA...
Abstract Background Peripheral hematopoietic stem cell (HSC) collections are needed for autologous transplantation (HSCT). Since 2015, our institution has utilized a secondary chamber mononuclear (MNC) protocol on the Spectra Optia apheresis system. Recently, new continuous collection (CMNC) was developed same device. As there is limited data available regarding use of CMNC in children, we compared efficiency (CE2), side effects, and clinical feasibility between two protocols patients <18...
ETV6-ABL1 gene fusion is a rare genetic rearrangement in variety of malignancies, including myeloproliferative neoplasms (MPN), acute lymphoblastic leukemia (ALL), and myeloid (AML). Here, we report the case 16-year-old male diagnosed with MPN, 7 months post-completion treatment for Burkitt leukaemia. RNA sequencing analysis confirmed presence an transcript, intact, in-frame ABL tyrosine–kinase domain. Of note, secondary ETV6-ABL1-rearranged neoplastic diseases have not been reported to...
Background: Children with acute myeloid leukemia (AML) are at high risk of life-threatening bacterial and fungal infection. However, little is known about the prevalence or severity adenovirus infection in this population. Objective was to describe characteristics, treatments outcomes children newly diagnosed AML. Methods: We performed a retrospective chart review based upon 2 multicenter cohort studies that focused on identifying factors for Inclusion criteria were patients de novo AML who...
EBV-associated PTLD following allogeneic HSCT is a serious complication associated with significant mortality. In this retrospective study, we evaluated whether lymphocyte subset numbers and CD8:CD20 ratio at time of EBV viremia in children undergoing could predict development PTLD. Absolute count, subsets, the were analyzed. Patients who treated preemptively rituximab for high blood viral load excluded. Out 266 patients transplanted during study period, 26 included analysis. divided into...
Data comparing hematopoietic stem cell transplantation (HSCT) using bone marrow (BM) or peripheral blood (PBSC) grafts in children after alemtuzumab-based conditioning are lacking. We investigated whether vivo T depletion alemtuzumab could reduce the risk of severe acute graft-versus-host disease (aGVHD) and chronic GVHD (cGVHD) HSCT with matched unrelated donor (MUD) BM PBSCs. This retrospective multicenter study included 397 (BM group, n = 202; PBSC 195) who underwent first MUD at 9...
Wiskott-Aldrich syndrome (WAS) is an X-linked disease characterized by microthrombocytopenia, eczema, immune deficiency, and autoimmune phenomena. Allogeneic hematopoietic stem cell transplantation (HSCT) the only curative treatment. Myeloablative conditioning most common regimen used for HSCT in patients with WAS to avoid risk of mixed donor chimerism autoimmunity post-HSCT. There limited data on use reduced intensity WAS. Here, we report a case severe phenotype transplanted successfully...
Human adenovirus (HAdV) is an important pathogen in patients after allogeneic hematopoietic stem cell transplantation (HSCT), resulting significant morbidity and mortality. Children seem to be more frequently affected than adults. Some HAdV infections may asymptomatic, but the most feared sequelaes are hemorrhagic cystitis, nephritis, hepatitis. Disseminated disease results mortality rates as high 80%. Consensus guidelines do not support use of routine screening for viremia following HSCT...
Background and objective: Many laboratory & clinical studies have suggested that there are important inverse relationships between expression of HER-2 oncoprotein hormonal receptors(ER,PR),the prognosis treatment also greatly depend on receptor neoplastic cells to define these using standard immunohistochemistry for HER-2,ER PR were performed in addition routine histopahtological grading carcinoma the breast. Methods: Between January 2006 December 2008 at histopathology lab Rezgary...
Introduction: Epstein-Barr virus (EBV)-related post-transplant lymphoproliferative disease (PTLD) developing after hematopoietic stem cell transplantation (HSCT) is a potentially life-threatening disease. Risk factors for development of PTLD HSCT include use anti-thymocyte globulin (ATG), T depletion and cord blood (CB) transplant. Hemophagocytic lymphohistiocytosis (HLH) uncommon allogeneic mostly associated with infections. Data on outcome patients concomitant HLH limited. Methods: In this...
Introduction: Viral infections are common complications of allogeneic stem cell transplantation (HSCT) and an important cause morbidity mortality especially in children. Cord blood (CB) HSCT carries a high risk for virus-related complications. Adenovirus (ADV), cytomegalovirus (CMV), Epstein-Barr virus (EBV), BK polyoma (BKV) usually being monitored pre-emptive therapy can reduce mortality. Other viruses not monitored. Data on outcome patients who undergo CB experience multiple viral is...