Chronic kidney disease (CKD), a pressing global health issue, affects millions and leads to end-stage renal (ESRD). Hemodialysis (HD) is crucial treatment for ESRD, yet its limited efficiency in removing protein-bound uremic toxins (PBUTs) results high morbidity mortality rates. A affinity of pharmaceutical drugs human serum albumin (HSA) can be leveraged compete effectively with PBUTs the same HSA binding sites, thereby enabling them capable displacing these toxins. One such drug ibuprofen...

A novel Ortho-Centrifugal Membrane Filter (O-CMF) was designed and assessed to tackle common issues in conventional laboratory centrifugal membrane filters, e.g. non-uniform transmembrane pressure concentration polarization, ease replacement. The O-CMF, manufactured by additive 3D printing acrylonitrile butadiene styrene, with area of 0.95 cm2, process a maximum liquid sample 9 mL. It tested nanofiltration aqueous solutions NaCl, MgSO4, lactose (concentrations 1-20 g/L) at pressures 6-24...

Two series of novel integral asymmetric monophasic hybrid membranes, cellulose acetate/silica/titania (CA/SiO2/TiO2-series 1) and acetate/titania (CA/TiO2-series 2), were developed by the coupling sol-gel technology a modified version phase inversion technique. SEM micrographs confirmed structure all membranes. ATR-FTIR ICP-OES results showed that, for membranes in 1, TiO2 is covalently bound to SiO2, which, turn, CA, while 2, directly CA matrix. Permeation experiments revealed that...

A novel cellulose acetate-based monophasic hybrid skinned amine-functionalized CA-SiO2-(CH2)3NH2 membrane was synthesized using an innovative method which combines the phase inversion and sol-gel techniques. Morphological characterization performed by scanning electron microscopy (SEM), chemical composition analyzed Fourier transform infrared spectroscopy in attenuated total reflection mode (ATR-FTIR). The of terms permeation properties carried out in-house-built single hemodialysis module...

Asymmetric bi-soft segment poly(ester urethane urea) (PEUU) membranes containing polycaprolactone (PCL) as a second soft are synthesized with PCL-diol ranging from 0% to 15% (w/w). Bulk and surface characteristics of the PEUU were investigated by scanning electron microscopy (SEM), static water contact angles, streaming potentials correlated hemocompatibility properties, namely, hemolysis thrombosis degrees. SEM analysis reveals asymmetric cross-sections top dense surfaces distinct...

Due to their high hemocompatibility and gas permeation capacity, bi-soft segment polyurethane/polycaprolactone (PU/PCL) polymers are promising materials for use in membrane blood oxygenators. In this work, both nonporous symmetric integral asymmetric PU/PCL membranes were synthesized, the properties of atmospheric gases N2, O2, CO2 through these experimentally determined using a new custom-built apparatus. Permeate pressure vs. time curves obtained at 37.0 °C feed pressures up 5 bar. Fluxes,...

In this paper, we propose an optimized protocol to synthesize reproducible, accurate, sustainable integrally skinned monophasic hybrid cellulose acetate/silica membranes for ultrafiltration. Eight different membrane compositions were studied, divided into two series, one and two, each composed of four membranes. The amount silica increased from 0 wt.% up 30 (with increments 10 wt.%) in while the solvent composition was kept constant within series (formamide/acetone ratio equals 0.57 0.73...

The production of medical devices follows strict guidelines where bio- and hemocompatibility, mechanical strength, tear resistance are important features. Segmented polyurethanes (PUs) an class polymers that fulfill many these requirements, thus justifying the investigation novel derivatives with enhanced properties, such as modulated carbon dioxide oxygen permeability. In this work, three segmented polyurethane-based membranes, containing blocks hard segments (HSs) dispersed in a matrix...

Oxygen mass transfer in a membrane blood oxygenator (MBO) surrogate system has been addressed this work. It consists of slit for water circulation as flow channel and constant pressure oxygen chamber separated by an integral asymmetric hemocompatible polyurethane‐based membrane. The oxygenated stream enters well‐mixed reservoir volume, V , the average concentration, measurement function time, t. In range short times, linearity vs. t allows direct determination permeation fluxes with no...

Currently available hemodialysis (HD) membranes are unable to safely remove protein-bound uremic toxins (PBUTs), especially those bonded human serum albumin (HSA). To overcome this issue, the prior administration of high doses HSA competitive binders, such as ibuprofen (IBF), has been proposed a complementary clinical protocol increase HD efficiency. In work, we designed and prepared novel hybrid conjugated with IBF, thus avoiding its end-stage renal disease (ESRD) patients. Two silicon...

In most extracorporeal filtration devices such as hemodialysis a peristaltic pump is used to circulate blood. Pump function requires the repeated compression of an elastomeric tube from which particles may be shed into circulatory system, process called spallation. Earlier studies are likely have missed large number small (<2 µm in diameter) that appear. The present study uses more modern equipment detects and sizes down 0.6 µm. As polyvinyl chloride (PVC) tubing commonly for this process,...

Cross‐flow filtration of fine suspensions through microsieves occurs in microprocessing. The interaction particles with surfaces microenvironments has been extensively studied, but predominantly monolayers and not an eye to microfiltration. Here, we introduce a microfiltration model that pertains might be seen as macroscopic environment, are large enough intrude significantly into the shear layer microchannel. Thus, particle accumulation upon sieve couples steady‐state filtrate flux...

Abstract Renal Replacement Therapies generally associated to the Artificial Kidney (AK) are membrane-based treatments that assure separation functions of failing kidney in extracorporeal blood circulation. Their progress from conventional hemodialysis towards high-flux (HFHD) through introduction ultrafiltration membranes characterized by high convective permeation fluxes intensified need elucidating effect membrane fluid removal rates on increase potentially blood-traumatizing shear...