A5015204327- Tryptophan and brain disorders
- Neuroscience and Neuropharmacology Research
- Sports Performance and Training
- X-ray Diffraction in Crystallography
- Crystallization and Solubility Studies
- Neurotransmitter Receptor Influence on Behavior
- Stress Responses and Cortisol
- Receptor Mechanisms and Signaling
- Cannabis and Cannabinoid Research
- Adipose Tissue and Metabolism
- Treatment of Major Depression
- Sports and Physical Education Studies
- Sports injuries and prevention
- Memory and Neural Mechanisms
- Synthesis and Reactivity of Sulfur-Containing Compounds
- Diet and metabolism studies
- RNA modifications and cancer
- Organophosphorus compounds synthesis
- Crystallography and molecular interactions
- RNA Research and Splicing
- Cholinesterase and Neurodegenerative Diseases
- Sulfur-Based Synthesis Techniques
- Motivation and Self-Concept in Sports
- Shoulder Injury and Treatment
- Sports Analytics and Performance
Health Research Institute of the Balearic Islands
2017-2025
Research Institute of Health Sciences
2017-2025
Universitat de les Illes Balears
2017-2025
University of the Basque Country
2023-2025
Universidad Pablo de Olavide
2018-2022
Imidazoline I2 receptors (I2-IRs) are altered in Alzheimer's disease (AD) patients and associated with analgesia. I2-IRs not structurally described, their pharmacological characterization relies on modulation by highly affine ligands. Herein, we describe the synthesis of (3-phenylcarbamoyl-3,4-dihydro-2H-pyrrol-2-yl)phosphonates endowed relevant affinities for human brain tissues. The optimal ADME pharmacokinetic profile a selected compound, 12d, secured its vivo exploration senescence...
Abstract Background The aging process causes anatomical and physiological changes that predispose to the development of late-life depression while reduces efficacy classical antidepressants. Novel fast-acting antidepressants such as ketamine might be good candidates explored in context aging, especially given lack previous research on its for this age period. Thus, aim present study was characterize ketamine’s effects older rats. Methods (30 min) repeated (7 days) antidepressant-like (5...
Abstract There is an urgent need for developing novel pharmacological treatment options adolescent depression, and to ensure optimal translational outcome the clinic, sex should be included as a biological variable in preclinical studies. In this context, present study compared antidepressant-like potential of ketamine cannabidiol, with clinical standard fluoxetine, rats exposed maternal deprivation (as model early-life stress), while including perspective. Moreover, changes drug efficacy...
Aberrant activation of tau kinases (tauK) has been proposed as a major step in hyperphosphorylation and misfolding, subsequent formation neurofibrillary tangles (NFT) Alzheimer's disease (AD). However, evidence tauK hyperactivation actual AD brains is scarce inconsistent, their role age-related cognitive decline remains undocumented. We evaluated activated/inhibited species CDK5/p35/p25, GSK3α/β, ERK1/2 well ten tau/phospho-tau (ptau) peptides (mapping Ser202, Thr217, Ser262, Ser305, Ser404...
Imidazoline I2 receptors (I2-IR), widely distributed in the CNS and altered patients that suffer from neurodegenerative disorders, are orphans a structural point of view, new I2-IR ligands urgently required for improving their pharmacological characterization. We report synthesis three-dimensional quantitative structure–activity relationship (3D-QSAR) studies family bicyclic α-iminophosphonates endowed with relevant affinities human brain I2-IR. Acute treatment mice selected compound...
Recent findings unveil the pharmacological modulation of imidazoline I2 receptors (I2-IR) as a novel strategy to face unmet medical neurodegenerative diseases. In this work, we report chemical characterization, three-dimensional quantitative structure-activity relationship (3D-QSAR) and ADMET in silico family benzofuranyl-2-imidazoles that exhibit affinity against human brain I2-IR most them have been predicted be permeable. Acute treatment mice with 2-(2-benzofuranyl)-2-imidazole, known...
Abstract Fas‐Associated protein with Death Domain (FADD), a key molecule controlling cell fate by balancing apoptotic versus non‐apoptotic functions, is dysregulated in post‐mortem brains of subjects psychopathologies, animal models capturing certain aspects these disorders, and several pharmacological agents. Since persistent disruptions normal functioning daily rhythms are linked conditions, oscillations over time biomarkers, such as FADD, could play crucial role the clinical outcome....
In searching for novel targets to design antidepressants, among the characterized imidazoline receptors (IR), I2 are an innovative therapeutical approach since they dysregulated in major depressive disorder and by classical antidepressant treatments. fact, several agonists have been their antidepressant-like potential, but results terms of efficacy were mixed exclusively reported male rodents. Since there well-known sex differences efficacy, this study potential effects induced two drugs,...
Aging predisposes to late-life depression and since antidepressants are known change their efficacy with age, novel treatment options needed for our increased aged population. In this context, the goal of present study was evaluate potential antidepressant-like effect cannabidiol in rats. For purpose, 19-21-month-old Sprague-Dawley rats were treated 7 days (dose range: 3-30 mg/kg) scored under stress forced-swim test. Hippocampal cannabinoid receptors cell proliferation evaluated as...
The cell fate regulator Fas-associated death domain (FADD) balances with non-apoptotic actions via its phosphorylated form. A recent study associated loss of cortical FADD cognitive decline and increased risk clinical dementia. Since the activation α2A-adrenoceptors improved memory deficits in various animal models working loss, present evaluated whether UK-14304, an α2-adrenoceptor agonist known to acutely regulate brain forms, would improve function middle-aged rats. Sprague-Dawley rats...
Las actividades físicas en el medio natural (AFMN) y/o las de aventura la naturaleza (AFAN), independientemente finalidad (educativa, recreativa, turística, deportiva), del que se lleven a cabo (terrestre, acuático o aéreo), perfil los practicantes, etc., presentan factores comunes definen y les confieren su carácter especial, genuino, diferencian demás físicas. El objetivo presente estudio surge pregunta ¿cuáles son estos universales entre este tipo manifestaciones naturaleza, singulares?...
The goal of this study was to establish technical and tactical performance goals for elite male volleyball players (Spanish first division). This paper is the result scientific collaboration between coaches researchers. process establishing reference values was: 1) conceptual analysis, criteria analysis players’ teams’ (researchers coaches), 2) mathematical data collection possible goals, 3) practical according their usefulness applicability following SMART principle. Seven were established...
Purpose: The purpose of this study was to assess the effect manner execution on serve efficacy in men’s beach volleyball. Material and methods: A total 5,132 serves, corresponding 84 matches (179 sets) Men's Beach Volleyball World Tour were studied sets). variables were: a) execution; b) zone c) distance; d) destination; e) efficacy; f) rally result. Results: Differences found different techniques regarding origin, destination, efficacy. jump involved a higher coefficient, it most used...
El objetivo del estudio fue revisar cómo se debe enseñar la técnica de desplazamiento en bloqueo, función lo que indican los manuales entrenamiento; y posteriormente, comprobar las técnicas utilizadas por jugadores centrales liga española voleibol. Para ello, realizó una revisión bibliográfica principales artículos entrenamiento, sobre ejecución bloqueo el bloqueadores utilizó muestra compuesta 275 acciones realizadas (11 partido analizados), correspondientes a primera vuelta 2016-17. Se un...
Objetivo: analizar las correlaciones entre la eco-intensidad (EI) del músculo cuádriceps medido por ecografía cuantitativa, y el salto vertical en niños edad escolar. Metodología: Se realizó un estudio transversal, comparativo no aleatorio. utilizó una muestra intencional compuesta 184 escolares, 7 10 años. Imágenes transversales fueron obtenidas femoral derecho para determinar recto o anterior, vasto intermedio crural lateral externo. La fuerza explosiva fue medida mediante pruebas de Salto...
Background: Many strategies are used to introduce athletes in sport. The aim of this study was analyse the satisfaction level and game preferences volleyball beach players at initial categories, regarding: (a) execution performance actions, (b) carrying out training tasks according their structure number players. Methods: A total 752 questionnaires were analyzed from who participated Spanish tournaments (n=492) (n=260) 2015. variables actions (serve, reception, set, attack, block dig) tasks,...