A5090968025- Neonatal Respiratory Health Research
- Neonatal and fetal brain pathology
- Optical Imaging and Spectroscopy Techniques
- Congenital Heart Disease Studies
- Respiratory Support and Mechanisms
- Airway Management and Intubation Techniques
- Non-Invasive Vital Sign Monitoring
- Mechanical Circulatory Support Devices
- Cardiovascular Conditions and Treatments
- Neuroscience of respiration and sleep
- Congenital Diaphragmatic Hernia Studies
- Functional Brain Connectivity Studies
- Pulmonary Hypertension Research and Treatments
- Ultrasound in Clinical Applications
- Cardiac Arrest and Resuscitation
- Fetal and Pediatric Neurological Disorders
- Genomic variations and chromosomal abnormalities
- Traumatic Brain Injury and Neurovascular Disturbances
- Prenatal Screening and Diagnostics
- Tracheal and airway disorders
- Cardiac Arrhythmias and Treatments
- Advanced MRI Techniques and Applications
- Infectious Encephalopathies and Encephalitis
- Injury Epidemiology and Prevention
- Medication Adherence and Compliance
London Health Sciences Centre
2018-2025
Western University
2018-2025
Children’s Health Research Institute
2020-2024
University Children's Hospital Tübingen
2023
Children's Hospital of Western Ontario
2023
Hospital for Sick Children
2020
University of Auckland
2012
Abstract Hypoxic-ischemic encephalopathy (HIE) results from a lack of oxygen to the brain during perinatal period. HIE can lead mortality and various acute long-term morbidities. Improved bedside monitoring methods are needed identify biomarkers health. Functional near-infrared spectroscopy (fNIRS) assess resting-state functional connectivity (RSFC) at bedside. We acquired fNIRS data 21 neonates with (postmenstrual age [PMA] = 39.96), in 19 scans were post-therapeutic hypothermia (TH), 20...
Importance Clinical observations of immediate improvement in fraction inspired oxygen (FiO 2 ) a proportion cases is often cited as the rationale for using inhaled nitric oxide (iNO) management acute pulmonary hypertension among very preterm neonates (gestational age, <32 weeks). However, clinical effectiveness such response pattern remains underinvestigated. Objective To identify factors associated with predischarge mortality receiving iNO hypertension, specific priori emphasis...
<title>Abstract</title> Background Escherichia coli meningitis imposes a significant global health burden, however, the risk factors to its morbidity and mortality remains unclear. This study aimed assess whether cerebrospinal pathology after infection can early predict disease severity. Methods A retrospective cohort of pediatric patients diagnosed with undergoing MRI was conducted in two tertiary medical centers China from March 2015 October 2022. findings their correlation outcomes were...
A major concern with preterm birth is the risk of neurodevelopmental disability. Poor cerebral circulation leading to periods hypoxia believed play a significant role in etiology brain injury, first three days life considered period when most vulnerable. This study focused on monitoring perfusion and metabolism during 72 h after infants weighing less than 1500 g. Brain was performed by combining hyperspectral near-infrared spectroscopy assess oxygen saturation oxidation state cytochrome c...
Post-hemorrhagic ventricular dilatation (PHVD) is characterized by a build-up of cerebral spinal fluid (CSF) in the ventricles, which increases intracranial pressure and compresses brain tissue. Clinical interventions (i.e., taps, VT) work to mitigate these complications through CSF drainage; however, timing procedures remains imprecise. This study presents Neonatal NeuroMonitor (NNeMo), portable optical device that combines broadband near-infrared spectroscopy (B-NIRS) diffuse correlation...
Characteristic changes in cerebral saturation (CrSO2), amplitude-integrated electroencephalography (aEEG), and echocardiography (ECHO) may be associated with intraventricular hemorrhage (IVH); however, the feasibility of their combined application is not known.The aim this work was to investigate safety multimodal hemodynamic monitoring extremely low gestational age (ELGA) infants first 72 h after birth.In prospective -observational study 50 born between 23 + 0 27 6 weeks gestation, we...
To compare effectiveness and safety of combination therapy (acetaminophen ibuprofen) to monotherapy (ibuprofen, indomethacin, or acetaminophen alone) in treatment the patent ductus arteriosus (PDA) premature neonates.This was a retrospective cohort study neonates admitted tertiary-level neonatal intensive care unit. Included were born at <32 weeks gestation received pharmacotherapy for PDA closure. Based on primary received, our divided into following four groups: indomethacin alone,...
Surfactant delivery via a thin endotracheal catheter during spontaneous breathing, technique called minimally invasive surfactant therapy (MIST), is an alternative to intubation and administration. There paucity of data regarding the administration high-volume using this technique. We conducted retrospective cohort study review safety, efficacy, procedural details pertaining 5 mL/kg BLES® MIST approach. In 2016, our centre initiated practice change allowing use as method in infants born at...
Surfactant delivery via a thin endotracheal catheter during spontaneous breathing; technique called minimally invasive surfactant therapy (MIST) is an alternative to intubation and administration. Procedural details among different centers vary, with marked differences in the choice of instill surfactant. Studies report use feeding catheters, multiaccess suction vascular more recently custom-built catheters for this purpose. The impact on procedural success adverse effects has not been...
Introduction: Minimally invasive surfactant therapy (MIST) can be used to treat neonatal respiratory distress syndrome in intensive care units (NICUs).Clinical and institutional variances MIST utilization persist globally with little published research regarding Canada.Therefore, the objective of this study was survey NICUs Canada.Methods: An online emailed 33 participating centres Canadian Neonatal Network TM (CNN) Evidence-based Practice for Improving Quality (EPIQ) Lung Health Group...
Comprehensive assessment of hemodynamic significance a patent ductus arteriosus (PDA) is common indication to perform targeted neonatal echocardiography (TNE). Impact implementation such an on PDA management decisions remains be reported. The objective this study compare PDA-related information and treatment before after introduction TNE service.
To characterize pulmonary artery Doppler flow profile (PAFP) patterns among infants receiving care in neonatal intensive units and to examine the association of PAFP with right ventricular (RV) hemodynamics.
Abstract Background The use of less invasive surfactant administration (LISA)/minimally therapy (MIST) has increased due to its potential advantage over traditional delivery methods through an endotracheal tube. Known complications for this procedure include failure the first attempt at insertion, desaturation, and bradycardia. To best our knowledge, is reported case pneumomediastinum subcutaneous emphysema following LISA. Case presentation A preterm newborn born 27 weeks gestation presented...
Abstract BACKGROUND Estimation of right ventricular peak systolic pressure (RVSP) or pulmonary using echocardiography is crucial in neonates with acute chronic hypertension. Conventionally echocardiography, the maximal velocity Tricuspid Regurgitant jet (TR Vmax) used to estimate RVSP. However, TR can often be absent unmeasurable neonates, resulting a need search for alternative echocardiographic measures neonates. Pulmonary Artery Doppler Waveform Parameter known as Acceleration Time (PAAT)...
Functional near-infrared spectroscopy (fNIRS) measures cortical changes in hemoglobin concentrations, yet cannot collected this information from the subcortices. To address drawback, we propose a machine-learning-based approach to predict cortical-thalamic functional connectivity using fNIRS data. We applied graph convolutional networks (GCN) on two datasets obtained adults and neonates, respectively. Each dataset contained data as input predictive models connectivities of magnetic resonance...
Minimally invasive surfactant therapy (MIST) has emerged as a preferred method of delivery. Pioneers this technique have described the use direct laryngoscopy (DL) for MIST. With increasing application video (VL) neonatal airway management, it is speculated that MIST techniques can be adapted with VL. Objective: To compare procedural success, operator ease use, and complication using VL vs. DL. Methods: This was retrospective, observational cohort study conducted at tertiary-level intensive...
Abstract Background Data regarding neonatal clinical experience with Vasopressin (VA) and Norepinephrine (NE) are limited to small studies. The lack of large-scale studies safety efficacy data is preventing the widespread adoption these agents. Objectives To describe epidemiological on utilization NE VA in neonates including their indications, effectiveness overall outcomes across 3 tertiary Neonatal Intensive Care Units (NICU) Canada. Design/Methods This retrospective cohort study involved...