A5052351588- Congenital Heart Disease Studies
- Neonatal Respiratory Health Research
- Cardiovascular Conditions and Treatments
- Congenital Diaphragmatic Hernia Studies
- Mechanical Circulatory Support Devices
- Cardiac Arrhythmias and Treatments
- Ultrasound in Clinical Applications
- Cardiac Arrest and Resuscitation
- Glaucoma and retinal disorders
- Respiratory Support and Mechanisms
- Hemodynamic Monitoring and Therapy
- Emergency and Acute Care Studies
- Retinal Diseases and Treatments
- Hospital Admissions and Outcomes
- Gallbladder and Bile Duct Disorders
- Intraocular Surgery and Lenses
- Preterm Birth and Chorioamnionitis
- Immune responses and vaccinations
- High Altitude and Hypoxia
- Congenital heart defects research
- Genomic variations and chromosomal abnormalities
- COVID-19 Impact on Reproduction
- LGBTQ Health, Identity, and Policy
- Ion channel regulation and function
- Infant Nutrition and Health
University of Alberta
2020-2025
Royal Alexandra Hospital
2022-2025
Stollery Children's Hospital
2021-2022
University of Illinois Chicago
2016-2018
Kasturba Medical College Hospital
2006-2010
Government Medical College
2007
Government Medical College
2006
Northwestern University
1996
Importance Evaluation and treatment of transitional circulation in neonates with extremely low gestational age (ELGA) varies greatly across centers. Objective To determine whether multimodal hemodynamic monitoring ELGA during the period (first 72 hours life) will improve cardiorespiratory-kidney health by decreasing vasoactive-ventilation-renal (VVR) score at 7 days. Design, Setting, Participants This unmasked, 2-arm randomized clinical trial included born a 23 0 to 28 6 weeks admitted...
Patent ductus arteriosus (PDA) is the most common cardiovascular problem that develops in extremely preterm infants and associated with poor clinical outcomes. Uncertainty exists on whether early pharmacotherapeutic treatment of a clinically symptomatic echocardiography-confirmed haemodynamically significant PDA improves Given wide variation approach to this gestational age (GA) group, randomised trial design essential address question. Before embarking large RCT vulnerable population, it...
Sudden unexpected clinical deterioration or cardiorespiratory instability is common in neonates and often referred as a "crashing" neonate. The established resuscitation guidelines provide an excellent framework to stabilize evaluate these infants, but it primarily based upon assessment only. However, sick limited identifying underlying pathophysiology. Crashing Neonate Protocol (CNP), utilizing point-of-care ultrasound (POCUS), specifically designed for use neonatal emergencies. It can be...
Importance Clinical observations of immediate improvement in fraction inspired oxygen (FiO 2 ) a proportion cases is often cited as the rationale for using inhaled nitric oxide (iNO) management acute pulmonary hypertension among very preterm neonates (gestational age, <32 weeks). However, clinical effectiveness such response pattern remains underinvestigated. Objective To identify factors associated with predischarge mortality receiving iNO hypertension, specific priori emphasis...
Congenital heart disease (CHD) is the most common form of human birth defects accounting for about 30% total anomalies. The prevalence CHD worldwide found to range between 1.0 – 150/ 1000 live births. causes can be categorized into three major groups such as, chromosomal (0.4 - 26.8%), single gene disorders (10-15%) and multiple factors (85-90%). Here we report association variations with in Mysore. A 192 confirmed cases were considered present study whose age ranged from 1 day 23 years....
Abstract Objectives Acetaminophen has gained interest in the neonatal community for its use management of hemodynamically significant patent ductus arteriosus (HsPDA) preterm infants. We conducted a systematic review randomized controlled trials (RCTs) comparing efficacy and safety acetaminophen with indomethacin HsPDA Methods searched PROSPERO, OVID Medline, EMBASE, Wiley Cochrane Library (CDSR Central), EBSCO CINAHL, SCOPUS from inception to June 15, 2021. Bibliographies identified studies...
Prematurity and bronchopulmonary dysplasia (BPD) are associated with poorly understood abnormalities of ventricular function. We therefore comprehensively compared biventricular function in infants without BPD.Prospective observational study extremely preterm (n = 20) 38) BPD using conventional advanced echocardiography at 28 days (T1) near-term (T2).Infants had lower birth gestational age (26.7±1.9 vs 27.4±1.1 weeks, p 0.047) weight (884±207 1108±190 g, 0.0001). was larger right ventricles...
The assessment of systemic blood flow is a complex and comprehensive process with clinical, laboratory, technological components. Despite recent advancements in technology, there no perfect bedside tool to quantify infants that can be used for clinical decision making. Each option has its own merits limitations, evidence on the reliability these physiology-based processes evolving. This article provides an extensive review interpretation limitations methods assess infants, highlighting...
We evaluated the effect of handoff training conducted during resident orientation on communication quality using a non-randomized between-subjects study, where group received structured, in-person training, and control no training. Handoff conversations for both groups were audio-recorded. Communication was measured as frequency breakdowns. found that had fewer breakdowns; however, after adjusting patient acuity days in unit, between two similar (OR=0.3, 95% CI=0.08-1.07, p=0.06). However,...
Background: Targeted neonatal echocardiography (TNE) and hemodynamic consultation have typically been performed by physicians. The Stollery Children’s Hospital intensive care unit (NICU) expanded their TNE training program to include nurse practitioners (NNPs), the first in North America. Purpose: This study examines thoughts perceptions of clinicians about incorporation NNPs providing investigates key facilitators challenges for consideration when planning future training, expansion service...
Introduction Patent ductus arteriosus (PDA) is the most common cardiovascular problem that develops in preterm infants and evidence regarding best treatment approach lacking. Currently available medical options to treat a PDA include indomethacin, ibuprofen or acetaminophen. Wide variation exists practices across Canada. In view of this large practice Canadian neonatal intensive care units (NICUs), we plan conduct comparative effectiveness study different pharmacotherapeutic agents used...
Ibuprofen is commonly used for the treatment of hemodynamically significant patent ductus arteriosus (PDA) in preterm infants. It seems that oral formulation incurs a higher closure rate and has better safety profile infants born > 26 weeks’ gestation. There no consensus across Canadian centers regarding minimum volume enteral feeds required prior to starting ibuprofen arteriosus, current practice comfort-based depending on centre local prevalence neonatal morbidities.
The early abnormal pulmonary vasoreactivity observed in babies at risk of Bronchopulmonary dysplasia (BPD) increases the vascular resistance. This can be assessed non-invasively using Time to Peak Velocity:Right Ventricular Ejection ratio (TPV:RVET) measured from artery Doppler waveform obtained echocardiogram. We postulate that screening for this predict BPD cohort. objective study was determine utility TPV:RVET prediction Extremely Low Birth Weight (ELBW) born less than 1250grams...
Abstract Introduction/Background BPD is a chronic lung disease that affects ELBW babies and contributes significantly to their morbidity mortality. The early abnormal vasoreactivity observed in at risk of increases the pulmonary vascular resistance can be assessed non-invasively using Time Peak Velocity: Right Ventricular Ejection ratio (TPV: RVET) calculated from artery doppler waveform. We postulate screening for this condition may useful predict cohort, which provide prognostic...