A5006876897- Immune Cell Function and Interaction
- T-cell and B-cell Immunology
- Immunotherapy and Immune Responses
- Cholangiocarcinoma and Gallbladder Cancer Studies
- MicroRNA in disease regulation
- Circular RNAs in diseases
- Cancer Immunotherapy and Biomarkers
- Natural product bioactivities and synthesis
- Cancer-related molecular mechanisms research
- Retinoids in leukemia and cellular processes
- RNA modifications and cancer
- Chemokine receptors and signaling
- Adenosine and Purinergic Signaling
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Pharmacological Effects of Natural Compounds
- CAR-T cell therapy research
- Microbial Metabolism and Applications
- Berberine and alkaloids research
- Plant Ecology and Soil Science
- Peptidase Inhibition and Analysis
- Protein Kinase Regulation and GTPase Signaling
- Genomics, phytochemicals, and oxidative stress
- Heat shock proteins research
- Colorectal and Anal Carcinomas
- Phytochemicals and Antioxidant Activities
Hunan University
2024-2025
Ministry of Water Resources of the People's Republic of China
2024
Hebei University of Engineering
2016-2024
Hunan University of Traditional Chinese Medicine
2024
Changjiang Water Resources Commission
2024
Xian Central Hospital
2023
Affiliated Hospital of Hebei University
2016-2022
Tongji University
2013
Tokyo Medical and Dental University
2010
Nagoya University
2004-2009
Hepatocellular carcinoma (HCC) is the fifth most common tumor worldwide and has a very poor prognosis. Its occurrence been on increase in recent years. Surgical resection liver transplantation are primary methods of treatment for HCC patients, but can only be applied to 15% patients. The median survival time unresectable or metastasizing patients few months. Existing systemic not effective advanced new method needed these It established that occurs multiple stages, however, pathogenesis at...
Abstract We recently identified CD8+CD122+ regulatory T cells that directly control CD8+ and CD4+ without intervention of APCs. In this study, we investigated the effector mechanism by using an in vitro regulation system. The profile cytokine expression revealed IL-10 was predominantly produced cells, whereas other cytokines were similarly expressed CD8+CD122− cells. Suppression both proliferation IFN-γ production blocked adding anti-IL-10 Ab to culture but not anti-TGF-β Ab. When removed...
Abstract Experimental autoimmune encephalomyelitis (EAE) is one of the best-documented animal models disease. We examined role CD8+CD122+ regulatory T cells, which we previously identified as naturally occurring cells that effectively regulate CD8+ in EAE. Depletion by vivo administration anti-CD122 mAb resulted persistent EAE symptoms. Transfer into mice at peak score clearly improved symptoms, indicating an important recovery phase This was further confirmed increase and a decrease number...
CD8+CD122+ regulatory T cells (CD8+CD122+ Treg) are naturally occurring Treg that effectively suppress the proliferation and IFN-γ production of both CD8+ CD4+ target cells. This study investigated molecular mechanisms recognition by using an in vitro culture system reconstitutes action these Naive co-cultured with pre-activated became active produced IL-10 suppressed from syngeneic mouse strains but not allogeneic incompatible MHC. By MHC-congeneic strains, MHC-restricted suppression was...
Abstract The importance of CD8 + CD122 Treg in the maintenance immune homeostasis has been previously demonstrated mice. Because expression pattern and humans is different from that mice, human correspond to murine have not identified. In this study, we performed DNA microarray analyses compare gene profiles cells − mice found CXCR3 was preferentially expressed cells. When analyzed cells, observed a definite population showed similar regulatory activities by vivo vitro assays. While are...
Abstract We identified CD8+CD122+ regulatory T cells (Tregs) and demonstrated their importance in the maintenance of immune homeostasis recovery from experimental autoimmune encephalomyelitis. In this paper, we show that Tregs effectively prevent cure colitis a mouse model. our experiments, was induced lymphocyte-deficient RAG-2−/− mice by transferring CD4+CD45RBhigh were excluded with CD4+ Tregs. Cotransfer clearly suppressed development colitis, suppressive effect similar to CD4+CD45RBlow...
Triple-negative breast cancer (TNBC) is a type of characterized by high molecular heterogeneity. Owing to the lack effective therapeutic strategies, patients with TNBC have poor prognosis. Prunella vulgaris L. has effects reducing swelling, dissolving knots and treating carbuncles mammary rocks. Modern pharmacological studies reported that it can effectively inhibit growth cancer. The main active antitumor components are triterpenoids (PVT); however, role potential mechanism PVT in remain...
Summary CD8 + CD122 regulatory T cells are a newly identified, naturally occurring type of cell that produce interleukin‐10 (IL‐10) and effectively suppress interferon‐γ (IFN‐γ) production from both CD4 target cells. Molecular mechanisms responsible for the recognition by were investigated in this study using an vitro culture system reconstitutes action these did not IL‐10 IFN‐γ allogeneic when they stimulated immobilized anti‐CD3 antibody alone, but clearly produced suppressed plus...
Objective: To study the expression of CMTM6 in colorectal cancer tissues and explore its relationship with tumor stage, lymph node metastasis, prognosis. Methods: All patients underwent surgical resection histopathological examination, collected tissue specimens were pathologically classified divided into 41 cases group 75 paracancerous to observe analyze PD-L1. Results: There was no statistically significant difference comparison gender, age, disease duration, other data between two groups...
Chemotherapy is one of the most important strategies in treatment cancer; however, chemoresistance restricts effect chemotherapy. Growing reports suggest that chloride channel-3 (ClC-3) involved regulating sensitivity multiple chemotherapeutic agents chemotherapy various tumours, while its role cholangiocarcinoma (CCA) still poorly understood. Herein, we observed ClC-3 was highly expressed CCA chemoresistant tissues and cisplatin-resistant cells QBC939/DDP, sensitivities QBC939 QBC939/DDP to...
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Objective: To observe the clinical efficacy and safety of regorafenib combined with immune checkpoint inhibitors in treatment patients advanced colorectal cancer pMMR/MSS type. Methods: 42 type admitted to Department Oncology our hospital from January 2022 September 2023 were randomly divided into observation group control group, 21 cases each. The was treated addition inhibitors, while given monotherapy, efficacy, adverse effects, survival two groups observed. Results: total remission rate...
Objective: This paper aims to evaluate the effect of laparoscopic complete mesocolic resection on efficacy and survival patients with colon cancer. Methods: 80 cancer were included in this study, 40 whom treated traditional radical surgery as control group, other observation group. The study period lasted from April 2022 2023, surgical indexes, postoperative recovery, quality life, occurrence complications two groups monitored throughout whole process compared analyzed. Results: therapeutic...
Cancer, an abnormal cell proliferation resulted from multi-factors,has the highest morbidity and mortality among all serious diseases. Considerable progress has been made in cancer biology recent years. Tumor immunology, stem cells (CSCs), autophagy, epithelial-mesenchymal transition (EMT) have become hot topics of interests this area. Detailed dissection these biological processes will provide novel directions, targets, strategies for pharmacological evaluation, mechanism elucidation, new...
Objective: To investigate the chronic respiratory symptoms and pulmonary function of adult residents in 3 towns Hongtong County, Shanxi Province, to explore their risk factors. Methods: The investigation lung status Hongdong County is based on regional population entire county County. project was initiated by Science Technology Department Linfen City coordinated Government. will be conducted townships City, Province from April November 2021: Demographic characteristics, symptoms, smoking...