A5050825526- DNA Repair Mechanisms
- CRISPR and Genetic Engineering
- Genomics and Chromatin Dynamics
- Epigenetics and DNA Methylation
- Leech Biology and Applications
- Healthcare and Venom Research
- Carcinogens and Genotoxicity Assessment
- Bacterial Genetics and Biotechnology
- Neonatal Respiratory Health Research
- Asthma and respiratory diseases
- Light effects on plants
- Genomics and Rare Diseases
- Inhalation and Respiratory Drug Delivery
University of Basel
2023
ETH Zurich
2021
University of Zurich
2013-2017
Abstract Global-genome nucleotide excision repair (GG-NER) prevents ultraviolet (UV) light-induced skin cancer by removing mutagenic cyclobutane pyrimidine dimers (CPDs). These lesions are formed abundantly on DNA wrapped around histone octamers in nucleosomes, but a specialized damage sensor known as DDB2 ensures that they accessed the XPC initiator of GG-NER activity. We report promotes CPD recruiting methyltransferase ASH1L, which methylates lysine 4 H3. In turn, methylated H3 facilitates...
Abstract Background Inhalation treatment frequently is used in dogs and cats with chronic respiratory disease. Little known however about the performance of delivery devices distribution aerosolized drugs lower airways. Objective To assess 3 impact variable durations inhalation on pulmonary extrapulmonary deposition nebulized 99m technetium‐diethylenetriamine‐pentaacetic acid ( Tc‐DTPA). Animals Ten university‐owned healthy Beagle dogs. Methods Prospective crossover study. Dogs inhaled...