A5083757198- Cancer-related molecular mechanisms research
- RNA modifications and cancer
- Lung Cancer Diagnosis and Treatment
- Cancer-related gene regulation
- Ferroptosis and cancer prognosis
- Cancer Genomics and Diagnostics
- Vagus Nerve Stimulation Research
- Vehicle Dynamics and Control Systems
- Cancer Immunotherapy and Biomarkers
- Circular RNAs in diseases
- RNA Research and Splicing
- Colorectal Cancer Treatments and Studies
- Pleural and Pulmonary Diseases
- Neuroendocrine Tumor Research Advances
- Inertial Sensor and Navigation
- Phonocardiography and Auscultation Techniques
- Bladder and Urothelial Cancer Treatments
- Image and Object Detection Techniques
- Myasthenia Gravis and Thymoma
- Metastasis and carcinoma case studies
- Music Therapy and Health
- Gear and Bearing Dynamics Analysis
- Autonomous Vehicle Technology and Safety
- Urinary and Genital Oncology Studies
- Robotics and Sensor-Based Localization
Peking University First Hospital
2011-2024
Peking University
2011-2024
Tsinghua University
2023
State Key Laboratory of Automotive Simulation and Control
2022-2023
Jilin University
2022-2023
University of Maryland, Baltimore
2020-2022
Veterans Health Administration
2020
Intestinal epithelial autophagy is crucial for host defense against invasive pathogens, and defects in this process occur frequently patients with inflammatory bowel disease (IBD) other mucosal disorders, but the exact mechanism that activates poorly defined. Here, we investigated role of RNA-binding protein HuR (human antigen R) posttranscriptional control autophagy-related genes (ATGs) intestinal epithelium. We found targeted deletion cells (IECs) specifically decreased levels ATG16L1...
The diagnostic value of six tumor markers was investigated and the appropriate combinations those to discriminate small cell lung cancer explored.Patients suspected with (1938) were retrospectively analyzed. Candidate from carcinoembryonic antigen (CEA), squamous carcinoma-related (SCC), cytokeratin 19 fragment 21-1 (CYFRA 21-1), neuron-specific enolase (NSE), tissue polypeptide (TPA), progastrin releasing peptide (ProGRP) selected construct a logistic regression model. receiver operating...
The high morbidity and mortality of lung cancer are serious public health problems. prognosis whether to apply immune checkpoint blockade (ICB) currently urgent problems be solved.Using R software, we performed Kaplan-Meier (K-M) analysis, Cox regression functional enrichment Spearman correlation the single-sample gene set analysis.On Tumor IMmune Estimation Resource (TIMER2.0) website, calculated abundance tumor-infiltrating cells (TIICs) adenocarcinoma (LUAD) squamous cell carcinoma (LUSC)...
Intestinal epithelial integrity is commonly disrupted in patients with critical disorders, but the exact underlying mechanisms are unclear. Long noncoding RNAs transcribed from ultraconserved regions (T-UCRs) control different cell functions and involved pathologies. Here, we investigated role of T-UCRs intestinal homeostasis identified T-UCR uc.230 as a major regulator renewal, apoptosis, barrier function. Compared controls, mucosal tissues ulcerative colitis mice or fasted for 48 hours had...
Abstract The human cervical cancer oncogene (HCCR) has been found to be overexpressed in a variety of cancers. However, the level expression HCCR and its biological function gastric are largely unknown. In this study, we evaluated several cell lines one normal mucosal line. We established 5-FU-resistant subline, expression. levels were high lines, was significantly increased subline. affected growth by regulating apoptosis cells, it had positive correlation with p-STAT3 Western blot...
Background: Cisplatin enhances the antitumor T cell response, and combination of PD-L1 blockade produces a synergistic therapeutic effect. However, clinical correlation between cisplatin immunotherapy in colon cancer (CC) is unknown. Methods: Using "pRRophetic" package, we calculated IC50 cisplatin. The IC50, resistance-related genes (CCL18 BCL2A1), were preliminarily verified TCGA further validated independent cohorts (GSE39582 GSE17538), cisplatin-resistant CC line DLD1, our own specimens....
This study explored how to improve the surgical technique reduce or avoid anastomotic leakage.From January 2012 December 2016, 101 consecutive patients with cancer of esophagus gastroesophageal junction underwent stapled anastomosis. The procedure included creating a tube-type stomach, fixing an inserted anvil, inspecting mucosa-to-mucosa alignment in lumen under direct vision after firing stapler, and, if found, manually repairing rupture mucous membrane anastomosis.A anastomosis was found...
KRAS is the most commonly mutated oncogene in human cancer, and mutant responsible for over 90% of pancreatic ductal adenocarcinoma (PDAC), lethal cancer. Here, we show that RNA polymerase II-associated factor 1 complex (PAF1C) specifically required survival PDAC but not normal adult cells. We PAF1C maintains cancer cell genomic stability by restraining overaccumulation enhancer RNAs (eRNAs) promoter upstream transcripts (PROMPTs) driven Kras. Loss leads to cancer-specific lengthening...
The binding of viruses to host-entry factor receptors is an essential step for viral infection. Many studies have shown that macrophages can internalize and degrade them in lysosomes clearance vivo. Inspired by these natural behaviors using SARS-CoV-2 as a testbed, we harvest from activated anchor the protein-receptor ACE2 bait, thus constructing lysosomal "TRAP" (lysoTRAP) selectively captures, internalizes, eventually degrades SARS-CoV-2. Through experiments with cells, female mice,...
The involvement of superior vena cava is a common condition in locally advanced thoracic tumors. Patients may benefit from the high risk operation. This study proposed programmed procedure to optimize surgical techniques, which can facilitate safety operation via median thoracotomy.A total 35 patients with disease involved underwent prosthetic vascular reconstruction thoracotomy. All were confirmed without distant metastasis including 16 pulmonary neoplasm and 19 mediastinal disease....
In this article, an electronic differential control algorithm suitable for distributed drive electric vehicles is proposed. Considering the vertical forces transfer of both sides wheels and vehicle stability during steering process, under condition constant road adhesion coefficient, two driving torque distribution methods are used. The first method that considers wheels, second add a yaw moment in order to acquire best result differential, article compares effects different speed ranges....
In this study, we introduced a novel surgical strategy to protect vagal nerve branches during radical thoracoscopic surgery in right lung cancer and explored the effects of branch preservation.We retrospectively studied 53 patients with right-sided clinically staged T1N0M0 between 2019 2020. All were treated total lobectomy mediastinal lymph node dissection same number stations. Of these, 22 adopted vagus protection dissection. Another 31 traditional as control group.The characteristics...
Complete thoracoscopic surgery has advanced, and its indication also been extended to complex procedures. The aim of this study is investigate the feasibility complete single-utility-port lobectomy with rib resection.A patient was diagnosed lung cancer single-rib metastasis. received segment costectomy through surgery. literature reviewed.The tumor staged at T1N1M1. made an uneventful recovery dismissed on day 4 after At last follow-up, alive well, no evidence disease 18 months...
PARP inhibitors can be used to treat solid tumors that often have mutations in important homologous recombination (HR) genes, such as BRCA1/2. While other kinds of could also experience HR deficiencies, including those associated with lung cancer, there is little information on the frequency these occurrences. Homologous deficiency (HRD) was induce particular DNA aberration profiles and related transcriptome alterations. Their presence identify whether an present or absent a tumor sample,...
Commercial vehicles can carry a lot of goods, so they are suitable for long-distance transportation, and this is why it has become an important part road traffic. During drivers prone to feeling fatigue because single working condition, which cause traffic accidents. The research commercial vehicle An adaptive cruise control (ACC) great significance, make the driver in relaxed state during driving. Because will encounter many situations process driving, there kinds targets design system....
In the electronic brake system (EBS) of commercial vehicles, due to compressibility gas, it is difficult achieve accurate control in pneumatic pipeline. To address this issue, a vertical load estimator based on unscented particle filtering (UPF) was designed, which can estimate during running vehicle. Then, EBS dynamics model established software, including signal sensor, single-channel bridge module, ABS solenoid valve, and dual-channel module. Finally, characteristics algorithm valve...