A5063889155- Tracheal and airway disorders
- Congenital heart defects research
- Congenital Ear and Nasal Anomalies
Fundación Ciencias Exactas y Naturales
2021-2022
University of Buenos Aires
2021-2022
CHARGE syndrome is a complex developmental disorder caused by mutations in the chromodomain helicase DNA-binding protein-7 (CHD7) and characterized retarded growth malformations heart nervous system. Despite public health relevance of this disorder, relevant cellular pathways targets CHD7 that relate to disease pathology are still poorly understood. Here we report chd-7, nematode ortholog Chd7, required for dauer morphogenesis, lifespan determination, stress response, body size...
ABSTRACT CHARGE syndrome is a complex developmental disorder caused by mutations in the chromodomain helicase DNA-binding protein7 (CHD7) and characterized retarded growth malformations heart nervous system. Despite public health relevance of this disorder, relevant targets CHD7 that relate to disease pathology are still poorly understood. Here we report chd-7 , nematode ortholog Chd7, required for dauer morphogenesis, lifespan determination, stress response. Consistent with our discoveries,...