A5082522374- Cellular Mechanics and Interactions
- Microtubule and mitosis dynamics
- Orbital Angular Momentum in Optics
- Microfluidic and Bio-sensing Technologies
- Polysaccharides Composition and Applications
- Nuclear Structure and Function
- Particle Dynamics in Fluid Flows
Institute of Photonic Sciences
2021-2025
Abstract Quantifying the mechanical response of biological milieu (such as cell’s interior) and complex fluids biomolecular condensates) would enable a better understanding cellular differentiation aging accelerate drug discovery. Here we present time-shared optical tweezer microrheology to determine frequency- age-dependent viscoelastic properties materials. Our approach involves splitting single laser beam into two near-instantaneous traps carry out simultaneous force displacement...
During the development of a multicellular organism, single fertilized cell divides and gives rise to multiple tissues with diverse functions. Tissue morphogenesis goes in hand molecular structural changes at level that result variations subcellular mechanical properties. As consequence, even within same cell, different organelles compartments resist differently stresses; mechanotransduction pathways can actively regulate their The ability adapt microenvironment tissue niche thus is part due...
Abstract Recording the mechanical response of biological samples, cell’s interior and complex fluids in general, would enable deeper understanding cellular differentiation, ageing drug discovery. Here, we present a time-shared optical tweezer microrheology (TimSOM) pipeline to determine frequency- age-dependent viscoelastic properties materials. Our approach consists splitting single laser beam into two near-instantaneous traps carry out simultaneous force displacement measurements with...
The use of non-invasive, optical tweezers active microrheology provides invaluable information on the mechanobiological principles that govern most cellular processes. principle using a single laser beam to trap —either endogenous droplets or microinjected probe beads— and measure both displacement force during an imposed oscillation has been proven insufficient for obtaining response function, ˆχ(ω), G modulus, ˆG(ω). As solution, additional with very low power can be used displacements...
During the development of a multicellular organism, single fertilized cell divides and gives rise to multiple tissues with diverse functions. Tissue morphogenesis goes in hand molecular structural changes at level that result variations subcellular mechanical properties. As consequence, even within same cell, different organelles compartments resist differently stresses; mechanotransduction pathways can actively regulate their The ability adapt microenvironment tissue niche thus is part due...