A5014191358- COVID-19 Clinical Research Studies
- Long-Term Effects of COVID-19
- COVID-19 diagnosis using AI
- Radiomics and Machine Learning in Medical Imaging
- Immunodeficiency and Autoimmune Disorders
- COVID-19 and healthcare impacts
- Sarcoidosis and Beryllium Toxicity Research
- SARS-CoV-2 and COVID-19 Research
- Cardiovascular Disease and Adiposity
- Muscle and Compartmental Disorders
- Hematological disorders and diagnostics
- Galectins and Cancer Biology
- Cystic Fibrosis Research Advances
- Inflammasome and immune disorders
- Takotsubo Cardiomyopathy and Associated Phenomena
- Medical and Agricultural Research Studies
- Heparin-Induced Thrombocytopenia and Thrombosis
- Diagnosis and treatment of tuberculosis
- Reproductive System and Pregnancy
- Amyloidosis: Diagnosis, Treatment, Outcomes
- Tracheal and airway disorders
- Infectious Encephalopathies and Encephalitis
- Respiratory Support and Mechanisms
- Medical History and Innovations
- Hormonal Regulation and Hypertension
City Clinical Hospital
2017-2023
A heterozygous mutation in the PTPN2 gene has recently been described several patients exhibiting symptoms of immune dysregulation. The encodes a ubiquitous non-receptor T-cell protein tyrosine phosphatase that exerts negative feedback on JAK-STAT pathway. Limited clinical data are available advocating use JAK inhibitors as an effective treatment for autoimmune complications deficiency. However, mechanism pathogenesis these suggests this possibility. We report 32-year-old male patient with...
SARS-CoV-2 infection continues to circulate in the population and play a role of immunological trigger. Polyserositis, described as marker immunoinflammatory diseases, today can often be found patients who have had COVID-19, even irrespective respiratory infection. Objective: study incidence pericardial pleural effusion based on lung CT scans with moderate severe acute COVID-19 pneumonia compare findings mortality rates. Materials methods. The exudation >5 mm according data from chest...
The article reviews studies that confirm the relationship of a negative prognosis with presence risk factors for cardiovascular complications during respiratory infections, including novel coronavirus infection COVID-19. presents relevant research results provide evidence on myocardial damage in infection. We present clinical case patient confirmed diagnosis COVID-19 and severe viral myocarditis, verified by histological immunohistochemical studies.
<h3></h3> Неоднократно описана практическая ценность компьютерной томографии (КТ) органов грудной клетки для диагностики пациентов с подозрением на коронавирусную инфекцию (COVID-19). В условиях высокой загруженности во время пандемии врачи-рентгенологи испытывают нехватку времени интерпретации результатов исследований. Использование технологий искусственного интеллекта (ИИ) может повлиять длительность формирования протокола описания КТ-исследований. <h3>ЦЕЛЬ ИССЛЕДОВАНИЯ</h3> Оценить...
The article highlights the course of long-term SARS-CoV-2 infection in a patient with secondary immunodeficiency developed B-cell-depleting therapy underlying disease. Analysis intrapatient virus evolution revealed an inpatient S:G75A mutation that alters 72GTNGTKR78 motif S-protein, possible role binding to alternative cellular receptors. Therapy ready-made COVID-19-globulin preparation (native human immunoglobulin G (IgG) derived from plasma convalescent COVID-19-patients) resulted rapid...
Aim. Compare radiological patterns of COVID-19 pneumonia with pulmonary histology in deceased patients. Materials and methods. The analysis recent lifetime CT studies patients was performed the identification all existing leading symptoms, including “ground glass”, “crazy paving”, consolidation, as well symptom complex (pattern) organizing pneumonia. Based on we selected target points for taking specimens by 3-D reconstructions. At autopsy lungs were entirely fixed into front then marked...
Guidelines on Biological Therapy for Bronchial Asthma of the European Academy Allergy and Clinical Immunology (EAACI) identified a number controversial issues additional outcome analysis using randomized clinical trials data from routine practice. In particular, there is unmet need to clarify algorithms prescribing biologicals predictors response its timing, taking into account risk factors multimorbidity. Omalizumab recombinant humanized monoclonal anti-IgE antibody IgG1 class used...
The novel severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) emerged in December 2019 China and quickly spread throughout the world, causing a pandemic. most vulnerable to virus were patients with immunodeficiencies, cardiac pathology, diabetes mellitus. According international data, infection rate cancer is higher than general population [1]. presence of hematological diseases significantly aggravated course coronavirus SARS-CoV-2 (COVID-19). foreign more 80% required...
Aim Dynamic assessment of the right heart in patients with COVID-19-associated pneumonia different severity during regression systemic inflammatory response (SIR).Material an methods This single-center prospective study included 46 novel coronavirus infection COVID-19 and viral according to chest multispiral computed tomography (CT). Laboratory echocardiographic examinations were performed.Results Based on results evaluation Clinical Condition Scale (CCS-COVID), divided into two groups:...
Vasculitis associated with the antineutrophilic cytoplasmic antibodies (ANCA) is an autoimmune systemic severe, often life-threatening, disease characterized by necrotizing inflammation of small vessels. In 75-90% cases ANCA-associated vasculitis (AAV), a rapidly progressive pauci-immune crescentic glomerulonephritis develops. Despite current treatment high-dose glucocorticoids and either cyclophosphamide or rituximab, patients have nine-fold increased mortality risk during first year...
Aldosterone levels increase in clinical practice may be due to primary or secondary hyperaldosteronism. Secondary hyperaldosteronism (CAA) is a syndrome caused by increased synthesis of renin juxtaglomerular apparatus the kidneys response lower perfusion pressure afferent glomerular arteriole. This mechanism leads activation renin-angiotensin-aldosterone system with consequent systemic blood pressure. Clinically manifested CAA (systemic) arterial hypertension, most common form parenchymal...
Common variable immune deficiency is the most common form of a group primary immunodeficiencies in adult patients. Pulmonary complications occupy leading positions. It development recurrent bronchopulmonary inflammatory diseases that considered to be one main causes death and disability patients with this disease. By presenting two clinical cases long diagnostic delays, authors try attract attention specialists related professions, which will minimize irreversible
The article provides a brief review of the literature on Takotsubo syndrome (TS) in pandemic new coronavirus infection A clinical case TS development young patient with COVID-19 who received immunosuppressive therapy early after allotransplantation cadaveric kidney is described diagnosis was established basis clinical, echocardiographic and ECG data In present observation, course extremely unfavorable ended death An autopsy followed by histological examination myocardium confirmed...
The global scientific community has recognized the high importance of lung CT as a diagnostic method. objective this study is to prove significance means predicting fatal outcomes COVID–19 viral pneumonia in patients with severe and extremely course disease. volume damage was retrospectively estimated postmortem studies 26 burden cancer 78 without any history (the control group). Lung performed on day death maximum 3 days before it. We concluded that died lesion two times smaller than those...
Prevention and treatment of postoperative purulent-inflammatory complications in urological practice remains a subject for study improvement all medical centers. The principle evidence must be taken as basis effectiveness therapy. In this the quality criteria demonstrated therapy are immunological parameters. purpose is to identify using monooxidase (NO) containing gas stream replenishing deficiency endogenous NO group patients; investigate reactivity patients under complex included nitrogen...
A computed tomography (CT) is the leading diagnostic technique in identifying detailed and specific signs of coronavirus infection (CI). The objective work to correlate between typical set that occur during CI phases diffuse alveolar damage (DAD). volume lung lesions 78 patients was retrospectively evaluated. All had CT from 1 3 day before death. 14 a targeted comparison «ground-glass, crazy paving pattern consolidation» with DAD. It found «ground glass» feature most characterized by...
Introduction. In the context of COVID-19 pandemic, one most important diagnostic methods is highresolution computed tomography lungs (HRCT), which highly sensitive for diagnostics viral pneumonia. Because a variety radiological changes in at different periods disease, it became necessary to compare detected by HRCT with morphological features disease. The aim research patterns and histological deceased COVID-19. Material methods. We analyzed 45 pieces from 14 (7 men/7 women), an average age...
The study aims to evaluate the signs and extent of lung damage in patients with pneumonia affected by COVID-19, associated end-stage renal disease (ERSD) without kidney disease, according data computed tomography (CT) chest organs. Material methods. group ERSD had 53 people consisted 59 people. Despite appropriate treatment, all died. autopsy confirmed presence caused COVID-19. average age was 68.40 ± 14.63 years. All 112 CT 2.12 0.94 days before death. Results. lethal outcome COVID-19...