A5063245849- Nanoparticle-Based Drug Delivery
- Characterization and Applications of Magnetic Nanoparticles
- Polymer Surface Interaction Studies
- Advanced Fiber Laser Technologies
- Electrospun Nanofibers in Biomedical Applications
- Magnetic and Electromagnetic Effects
- Immune cells in cancer
- RNA Interference and Gene Delivery
- Nonlinear Optical Materials Studies
- Diamond and Carbon-based Materials Research
- Nanoplatforms for cancer theranostics
- Nanoparticles: synthesis and applications
- Microfluidic and Bio-sensing Technologies
- Cancer Research and Treatments
Pirogov Russian National Research Medical University
2022-2024
Background/Objectives: Neutrophils are emerging as promising candidates for cell-based nanodrug delivery to tumors due their unique biological properties. This study aims investigate the mechanisms of nanoparticle internalization by neutrophils, specifically focusing on liposomes, poly(lactic-co-glycolic acid) (PLGA), and magnetite nanoparticles. Understanding these could enhance efficiency neutrophil-based cancer treatment. Methods: were isolated from peripheral blood mice bearing 4T1...
Insufficient drug accumulation in tumors is still a major concern for using cancer nanotherapeutics. Here, the neutrophil-based delivery of three nanoparticle types—liposomes, PLGA, and magnetite nanoparticles—was assessed both vitro vivo. Confocal microscopy flow cytometry analysis demonstrated that all studied nanoparticles interacted with neutrophils from peripheral blood mice 4T1 mammary adenocarcinoma without significant impact on neutrophil viability or activation state. Intravital...
Abstract Hyperthermia plays a significant role in cancer treatment by inducing cell damage through temperature elevation, often used alongside other modalities. During hyperthermia therapy, control is crucial. Here, we report on simple synthesis route of hybrid plasmonic nanodiamonds either completely wrapped with an Au shell ( NV@Au ) or densely covered NPs NV@SiO 2 @Au ). Such integration advantageous both for heating and precise thermometry at nanoscale. After structural optical...
Magnetic nanoparticles based on iron oxide attract researchers’ attention due to a wide range of possible applications in biomedicine. As synthesized, most the magnetic do not form stable colloidal solutions that are required for evaluation their interactions with cells or efficacy animal models. For further application biomedicine, must be modified biocompatible coating. Both size and shape chemical composition coating have an effect nanoparticles’ living objects. Thus, universal method...
Human glioblastoma multiforme (GBM) is a primary malignant brain tumor, radically incurable disease characterized by rapid growth resistance to classical therapies, with median patient survival of about 15 months. For decades, plethora approaches have been developed make GBM therapy more precise and improve the diagnosis this pathology. Targeted delivery mediated use various molecules (monoclonal antibodies, ligands overexpressed tumor receptors) one promising methods achieve goal. Here we...