A5023221949- HIV Research and Treatment
- Neuroinflammation and Neurodegeneration Mechanisms
- interferon and immune responses
- Inflammasome and immune disorders
- Immune Response and Inflammation
- Mosquito-borne diseases and control
- Immune Cell Function and Interaction
- COVID-19 Impact on Reproduction
- Immune cells in cancer
- Cytomegalovirus and herpesvirus research
- Cannabis and Cannabinoid Research
- Extracellular vesicles in disease
- HIV-related health complications and treatments
- Tryptophan and brain disorders
Icahn School of Medicine at Mount Sinai
2023-2024
Tufts University
2021
Receptor interacting protein kinase 1 (RIPK1) mediates cell death and inflammatory signaling is increased in multiple sclerosis (MS) brain samples. Here, we investigate the role of glial RIPK1 activity mediating MS pathogenesis. We demonstrate levels correlate with disease progression. find microglia are susceptible to RIPK1-mediated identify an gene signature that may contribute neuroinflammatory milieu patients. uncover a distinct for astrocytes regulating absence confirm...
Abstract Myeloid cells comprise the majority of immune in tumors, contributing to tumor growth and therapeutic resistance. Incomplete understanding myeloid response driver mutation intervention impedes effective design. Here, by leveraging CRISPR/Cas9-based genome editing, we generate a mouse model that is deficient all monocyte chemoattractant proteins. Using this strain, effectively abolish infiltration genetically engineered murine models de novo glioblastoma (GBM) hepatocellular...
HIV-1 infection, even with effective antiretroviral therapy (ART), is associated chronic inflammation and immune dysfunction, contributing to long-term health complications. Nicotine use, prevalent among people HIV (PWH), known exacerbate activation disease progression, but the precise biological mechanisms remain be fully understood. This study sought uncover synergistic effects of infection nicotine on cell function, focusing beneficial insights into NLRP3 inflammasome activation,...