A5058500648- Esophageal Cancer Research and Treatment
- Esophageal and GI Pathology
- Tuberculosis Research and Epidemiology
- Diagnosis and treatment of tuberculosis
- Radiomics and Machine Learning in Medical Imaging
- Mycobacterium research and diagnosis
- Psychiatric care and mental health services
- Blood Pressure and Hypertension Studies
- Schizophrenia research and treatment
- Epigenetics and DNA Methylation
- Mental Health and Psychiatry
- Mental Health and Patient Involvement
- Medical Imaging Techniques and Applications
- Cardiac Arrhythmias and Treatments
- Health Systems, Economic Evaluations, Quality of Life
- Gastric Cancer Management and Outcomes
- Family Caregiving in Mental Illness
- Cardiac Imaging and Diagnostics
- Diagnosis and Treatment of Venous Diseases
- Atrial Fibrillation Management and Outcomes
- Metastasis and carcinoma case studies
- Cardiovascular Disease and Adiposity
- Advanced X-ray Imaging Techniques
- Healthcare Quality and Management
- Pharmaceutical Practices and Patient Outcomes
University College London
2019-2024
University College Lahore
2024
Watford General Hospital
2015-2023
RELX Group (Netherlands)
2022
Wellcome / EPSRC Centre for Interventional and Surgical Sciences
2022
University College Hospital
2021
St Mark's Hospital
2016-2019
St. Mark's Hospital
2018
West Hertfordshire Hospitals NHS Trust
2015-2016
Bahá'í Agency for Social and Economic Development
2012
‘Recovery’ is usually taken as broadly equivalent to ‘getting back normal’ or ‘cure’, and by these standards few people with severe mental illness recover. At the heart of growing interest in recovery a radical redefinition what means those health problems. Redefinition process personal discovery, how live (and well) enduring symptoms vulnerabilities opens possibility all. The ‘recovery movement’ argues that this reconceptualisation personally empowering, raising realistic hope for better...
Long-term durability data for effectiveness of radiofrequency ablation (RFA) to prevent esophageal adenocarcinoma in patients with dysplastic Barrett's esophagus (BE) are lacking.We prospectively collected from 2535 BE (mean length, 5.2 cm; range, 1-20) and neoplasia (20% low-grade dysplasia, 54% high-grade 26% intramucosal carcinoma) who underwent RFA therapy across 28 UK hospitals. We assessed rates invasive cancer performed detailed analyses 1175 assess clearance dysplasia (CR-D)...
Abstract Background Early detection of esophageal cancer is critical to improve survival. Whilst studies have identified biomarkers, their interpretation and validity often confounded by cell-type heterogeneity. Results Here we applied systems-epigenomic deconvolution algorithms a discovery set encompassing RNA-Seq DNA methylation data from adenocarcinoma (EAC) patients matched normal-adjacent tissue, in order identify robust free the confounding effect posed We 12 gene-modules that are...
This multicenter, double-blind, placebo-controlled study was conducted to evaluate dose-response effects and safety of once-daily administration pravastatin, a new inhibitor 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase. Pravastatin 5, 10, 20, 40 mg or placebo administered at bedtime 150 patients with primary hypercholesterolemia inadequately controlled on low-fat, low-cholesterol (AHA Phase I) diet. After 8 weeks treatment, pravastatin produced dose-dependent reductions in...
Acute cardiac tamponade is a medical emergency that requires urgent therapy. Removal of pericardial fluid by pericardiocentesis or open surgical drainage effective,1 2 3 but delays may occur while the catheterization laboratory operating room being prepared. Alternative methods would be useful as interim therapy, if they were also effective.The time-honored therapy for acute intravascular volume expansion.1 , 4 5 6 Vasodilator drugs have been recommended, especially in combination with...
Angiotensin-converting enzyme (ACE) inhibition with captopril is accepted therapy for the treatment of symptomatic congestive heart failure. In this trial, we compared new ACE inhibitor, lisinopril, to during a 12-week randomized double-blind study. One hundred twenty-nine patients New York Heart Association class II, III, or IV failure were receive either lisinopril 5 mg/day (n = 64) 37.5 65) in 15 centers. Drug doses could be titrated upwards every 4 weeks. The primary measure drug...
This multicenter, dose-ranging study evaluated the antihypertensive effectiveness of once-daily administration fosinopril sodium in 220 patients with supine diastolic blood pressure 95-115 mm Hg. After a 4-week placebo period, were randomly assigned to double-blind therapy either or 10, 40, 80 mg once daily for 4 weeks. If treatment goals not met, chlorthalidone 25 mg/day was added weeks 5 8. Thereafter, could enter long-term, open-label phase and receive 10-80 plus chlorthalidone, if...
Objective The aim of this study was to determine the occurrence latent tuberculosis infections (LTBI) and active TB in a cohort patients with inflammatory bowel disease (IBD) treated biologics. We also examined effects immunosuppressive drugs on indeterminate interferon-gamma release assays (IGRA) LTBI screening. Design Retrospective biologics between March 2007 November 2015. Setting St Mark’s Hospital, North West London, UK. Patients 732 IBD who were screened for using either tuberculin...
Fifty-three female in-patients of a psychiatric hospital were interviewed to obtain their views on own safety and security, what improvements they would recommend. Most had experienced sexual harassment few been victims assault. There was reluctance report incidents staff. The majority felt that female-only wards improve safety. Other recommendations included higher staffing levels, more staff awareness vigilance, single rooms with curtains the doors.
Left parasternal cardiograms were recorded at the fifth intercostal space in 30 patients with mitral regurgitation. Early systolic outward movements (E), late (LOM), and ratio of LOM area to total occupied by left cardiogram (LPC area) examined. Thirteen had pure regurgitation due ruptured chordae tendineae (ten patients) or "floppy valve" (three patients). In these LOM/E correlated significantly volume determined difference between angiographic Fick stroke volumes, ( r = 0.93, P < 0.01),...
AbstractClozapine has been shown to be effective in up 60% of patients with previously treatment resistant schizophrenia. There is a 3% risk neutropenia and the associated requirement for regular haematological monitoring contributes clozapine's high cost. This leads pressure stop if quantifiable improvement does not occur. However, traditional outcome measures such as BPRS do incorporate opinions or their relatives. We found relatives were more positive than ward staff about clozapine they...
Journal Article Section 47 and its use with mentally disordered people Get access Paul Wolfson, Wolfson Senior Registrar in Psychiatry St Thomas's HospitalLondon Search for other works by this author on: Oxford Academic PubMed Google Scholar Michael Cohen, Cohen Consultant Psychogeriatrician United Medical Dental SchoolsGuy's Hospital, London SE1 James Lindesay, Lindesay Lecturer Psychogeriatrics Bexley Kent Elaine Murphy Professor of Public Health, Volume 12, Issue 1, February 1990, Pages...
Aims and method To assess the extent of user involvement in care planning, from users' perspective. Fifty Care Programme Approach (CPA) meetings across five consultant teams were included using quota sampling. Data concerning was collected by direct observation, semi-structured interviews with users keyworkers a review CPA documentation. Results User needs assessment decision-making poor, as knowledge planning information provision to users. Clinical implications Limited resources conflict...