A5101985570- Cervical Cancer and HPV Research
- Occupational and environmental lung diseases
- Probiotics and Fermented Foods
- Milk Quality and Mastitis in Dairy Cows
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Phytochemicals and Antioxidant Activities
- Endometrial and Cervical Cancer Treatments
- Occupational exposure and asthma
- Antimicrobial Peptides and Activities
- Nuts composition and effects
- Radiology practices and education
- Simulation-Based Education in Healthcare
- Innovations in Medical Education
- Pleural and Pulmonary Diseases
- Ovarian cancer diagnosis and treatment
- Pancreatic and Hepatic Oncology Research
- Digestive system and related health
- Colorectal and Anal Carcinomas
- Urinary and Genital Oncology Studies
- Heavy Metals in Plants
- Iron Metabolism and Disorders
- Immunotoxicology and immune responses
- Health Sciences Research and Education
- Reproductive tract infections research
- Phagocytosis and Immune Regulation
Centre Hospitalier de l’Université de Montréal
2024
Curtin University
2010-2023
Society for Chemical Engineering and Biotechnology
2022
Manhattan College
2004
Graduate School USA
1997
Queen Elizabeth II Medical Centre
1996-1997
Pathwest Laboratory Medicine
1997
The University of Western Australia
1995
Southern Research Station
1983
Background Biofilm formation by Staphylococcus aureus is an important virulence attribute because of its potential to induce persistent antibiotic resistance, retard phagocytosis and either attenuate or promote inflammation, depending upon the disease syndrome, in vivo. This study was undertaken evaluate significance strength biofilm clinical bovine mastitis-associated S. mammary tissue damage using a mouse mastitis model. Methods Two strains same capsular phenotype with different forming...
Determinations of exposure-response relationships between crocidolite and the major asbestos-related diseases in Wittenoom cohort have previously depended on validity estimates airborne exposure to asbestos. This work aims validate measurements by obtaining concentrations uncoated fibers asbestos bodies retained lungs individual workers, estimate half-life lungs. Samples lung tissue, excluding tumor, all former workers known died Western Australia (WA) were sought from teaching hospitals,...
Abstract Introduction CIN 2 has a high rate of spontaneous regression in young women and may be managed conservatively appropriately selected patients. This study aimed to investigate health outcomes aged 18–24 years with biopsy‐confirmed 2. Material methods A retrospective cohort Western Australian diagnosed on cervical biopsy from 1 January 2001 31 December 2010. Women who had not received treatment at ≥4 months following diagnosis were classified as ‘conservatively’. Subsequent cytology...
This study was undertaken to compare the immunogenicity and protective potential of biofilm vs planktonic Staphylococcus aureus vaccine for prevention mastitis using mouse as a model system. Mice immunized with formalin-killed whole cell S. residing in when delivered via an intramammary route produced mediated immune response. this showed significant reductions colonization by mammary glands, severity clinical symptoms tissue damage glands comparison mice cells aureus. The administered...
Protein A, encoded by the spa gene, is one of major immune evading MSCRAMM S. aureus, demonstrated to be prevalent in a significant percentage clinical bovine mastitis isolates Australia. Given its' reported significance biofilm formation and superior performance aureus versus planktonic vaccine mouse model, it was interest determine immunogenicity protective potential A as candidate against using model. Pregnant Balb/c mice were immunised with emulsified an alum-based adjuvant subcutaneous...
The absorption of food iron can be greatly influenced by other constituents in the diet such as ascorbic acid (Vitamin C) and phenolics. Ascorbic increases bioavailability converting Fe3 to Fe2 , while phenolics reduce binding it. Phenolics (e.g., tannins), however, are often not included diets captive animals because they 1) act digestibility reducers dietary protein, 2) require feeding fresh leaf material which hard obtain on a regular basis. Conversely, levels excessive from fruit...
Background: The level of agreement between anal cytology and histopathology is not clear with only a few studies evaluating the reliability specimen reporting. Australian data in relation to this are limited. Methods: results paired specimens received 2002 2008 from patients who were referred within sexual health clinic retrieved anatomical pathology database. A total 248 samples 154 (21 females, 133 males) participants extracted. Concurrent high risk human papilloma virus (hrHPV) DNA assay...
In 2006, Australia adopted a revised cervical cytology terminology system, known as the Australian Modified Bethesda System (AMBS). One substantial change in AMBS was introduction of diagnostic category atypical endocervical cells (AEC) undetermined significance.The aim this study to investigate incidence histologically confirmed high-grade dysplasia (cervical intra-epithelial neoplasia (CIN) grades 2 and 3 adenocarcinoma situ (ACIS)), carcinoma endometrial women presenting with AEC on...
Chronic pancreatitis increases the risk of developing pancreatic cancer through upregulation pathways favouring proliferation, fibrosis, and sustained inflammation. We established in previous studies that ligand tumour necrosis factor (TNF)-like weak inducer apoptosis (TWEAK) signals its cognate receptor fibroblast growth factor-inducible 14 (Fn14) to regulate these underlying cellular processes chronic liver injury niche. However, role TWEAK/Fn14 signalling pathway disease is entirely...
Background In A ustralia, high‐risk human papillomavirus ( HR HPV ) testing is recommended for follow‐up of women treated a high‐grade squamous intra‐epithelial lesion HSIL ). The sensitivity critical to identify at risk further cervical disease. this management protocol known as the ‘ T est C ure’ o Aim To conduct population‐based study investigating practitioners' compliance with . Materials and Methods Women an between five‐year period 01 J 2006 31 D ec 2010 were identified followed up...
Simulation-based education (SBE) has successfully been implemented in several healthcare professions, more so the fields of medicine and nursing. Laboratory courses prepare medical scientists for employment pathology laboratories typically via a staged training regime. techniques related to diagnostic disciplines are introduced students graduated fashion over time development professional skills technical competencies. For specialising cytology, there continual changes scope practice...
Transthoracic echocardiography, a validated tool for risk assessment in non-pregnant population with sickle cell disease (SCD), uses tricuspid regurgitant velocity (TRV) over 2.5 m/s is an independent mortality factor. Its applicability obstetrics lacks sufficient evidence.
Abstract A series of 206 necropsies in Western Australia (WA) have had routine counts made asbestos bodies samples lung tissue using conventional light microscopy. Thirty‐two cases worked the industry at Wittenoom, WA and (log) their correlated well with estimates cumulative airborne exposure to crocidolite fibers (r = 0.60). There was no association between number time since ceased. In subjects without known asbestos, there a weak but nonsignificant increase increasing age, 26% having...
<h3>Objectives</h3> While dose-response relationships between airborne crocidolite and malignant mesothelioma (MM) have been well established, corresponding for lung tissue burden are less clear. The objective was to examine the association of asbestos other mineral fibres occurrence MM. <h3>Methods</h3> Asbestos body (AB) uncoated fibre analysis performed on from 123 confirmed cases MM (46 Wittenoom 77 elsewhere) 294 controls (141 a series resections cancer 152 necropsies where possibility...