A5102888460- Transplantation: Methods and Outcomes
- Tracheal and airway disorders
- Lung Cancer Diagnosis and Treatment
- Organ Transplantation Techniques and Outcomes
- Esophageal and GI Pathology
- Pleural and Pulmonary Diseases
- Medical Imaging and Pathology Studies
- Gastroesophageal reflux and treatments
- Esophageal Cancer Research and Treatment
- Mechanical Circulatory Support Devices
- Cystic Fibrosis Research Advances
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Renal Transplantation Outcomes and Treatments
- Gastric Cancer Management and Outcomes
- Pulmonary Hypertension Research and Treatments
- Neonatal Respiratory Health Research
- Pneumocystis jirovecii pneumonia detection and treatment
- Dysphagia Assessment and Management
- Anesthesia and Pain Management
- Vascular Anomalies and Treatments
- Ultrasound in Clinical Applications
- Eosinophilic Esophagitis
- Congenital Diaphragmatic Hernia Studies
- Polyomavirus and related diseases
- Adrenal and Paraganglionic Tumors
Centre Hospitalier de l’Université de Montréal
2016-2025
Université de Montréal
2015-2025
Media Working Group
2019
Hôpital Notre-Dame
2003-2017
Society of Thoracic Surgeons
2015-2017
Valve (United States)
2017
Emory and Henry College
2017
University of Minnesota
2016
McGill University
2003-2014
Thoracic Surgery Foundation
2012
Airway damage and remodelling are important components of lung pathology progression in cystic fibrosis (CF). Although repair mechanisms engaged to restore the epithelial integrity, these processes obviously insufficient maintain function CF airways. Our aims were therefore study how basic transmembrane conductance regulator (CFTR) defect could impact wound healing determine if CFTR correction improve it. Wound-healing experiments, as well cell migration proliferation assays, performed early...
IL-13 is an important mediator of allergen-induced airway hyperresponsiveness. This Th2 cytokine, produced by activated T cells, mast and basophils, has been described to mediate a part its effects independently inflammation through direct modulation the smooth muscle (ASM). Previous studies demonstrated that induces hyperresponsiveness in vivo enhances calcium signaling response contractile agonists vitro. We hypothesized drives human ASM cells (ASMC) procontractile phenotype. evaluated...
Cystic fibrosis (CF) is caused by mutations in the gene encoding CF transmembrane conductance regulator (CFTR). The most common mutation, ΔF508, causes retention of CFTR endoplasmic reticulum (ER). Some abnormalities can be explained altered Ca2+ homeostasis, although it remains unknown how influences calcium signaling. This study examined novel hypothesis that store-operated entry (SOCE) through Orai1 abnormal CF. significance Orai1-mediated SOCE for increased interleukin-8 (IL-8)...
OBJECTIVEAcute renal failure (ARF) frequently complicates lung transplantation. This study determined the prevalence, predictive factors, and consequences of ARF on long-term function survival.
Primary graft dysfunction (PGD) is characterized by alveolar epithelial and vascular endothelial damage inflammation, lung edema hypoxemia. Up to one-third of recipients develop the most severe form PGD (Grade 3; PGD3). Animal studies suggest that neutrophils contribute inflammatory process through neutrophil extracellular traps (NETs) release (NETosis). NETs are composed DNA filaments decorated with granular proteins contributing occlusion associated PGD. The main objective was correlate...
To assess development of mucosal damage in the esophageal remnant regard to level esophagogastrostomy reconstruction either a right chest or left neck position.Esophagectomy with gastric interposition creates an vivo human model pathologic reflux potential for long-term disease complications.Eighty-four esophagectomy patients were assessed over time by symptoms, endoscopy and biopsies their after operation. The anastomosis was upper (n = 36) cervical position 48). Visual quantification...
Atrial fibrillation (AF) is common after thoracic surgery. Limited data exist concerning the incidence of AF, its impact on mortality, effectiveness therapy, and risk factors AF pulmonary transplantation.We reviewed medical files 224 consecutive lung transplant recipients who underwent surgery over a 10-year period at large Canadian center. We collected patient characteristics, in-hospital treatments, outcomes. Time-to-event analysis was used to account for follow-up models generated assess...
Pheochromocytomas (PCCs) and paragangliomas (PGLs) (PPGLs) are rare tumours arising from the chromaffin cells. There is evidence suggesting a link between hypoxemia PPGLs. Chronic hypoxia can lead to gain of function somatic variants in EPAS1 gene that encodes for hypoxia-inducible factor 2-alpha (HIF-2α), involved PPGL tumorigenesis. To describe case PCC pulmonary transplant patient characterize tumour's genetic background. A 47 year-old man underwent lung chronic obstructive disease...
ABSTRACT Background Mycobacterium abscessus complex is known to cause life‐threatening disease in lung transplantation (LT) recipients (LTRs). Therefore, many centers consider the presence of M. as a relative contraindication LT. Methods We conducted multicenter retrospective cohort study including all 4 LT Canada. All LTRs transplanted 2006–2016 with at least one respiratory sample positive for prior or posttransplantation were included. Pulmonary was defined using American Thoracic Society...
Abstract Background Many cystic fibrosis (CF) patients display airway hyperresponsiveness and have symptoms of asthma such as cough, wheezing reversible obstruction. Chronic bacterial colonization, associated with neutrophilic inflammation high levels interleukin-8 (IL-8) is also a common occurrence in these patients. The aim this work was to determine the responsiveness smooth muscle IL-8 CF compared non-CF individuals. Methods Experiments were conducted on cultured ASM cells harvested from...
ObjectivesTo identify factors associated with prolonged postoperative length of stay (LOS) after VATS lobectomy (VATS-L), explore potential intersurgeon variation in LOS and ascertain whether or not early discharge influences hospital readmission rates.MethodsWe conducted a retrospective analysis patients who underwent VATS-L at single academic center between 2018 2021. Each procedure was performed by 1 7 experienced thoracic surgeons. The primary end point interest LOS, defined as an index...