A5008143899- Immunotherapy and Immune Responses
- T-cell and B-cell Immunology
- Immune Cell Function and Interaction
- Phagocytosis and Immune Regulation
- IL-33, ST2, and ILC Pathways
- Neonatal and fetal brain pathology
- Neonatal Respiratory Health Research
- Asthma and respiratory diseases
- Escherichia coli research studies
- Mesenchymal stem cell research
- Psoriasis: Treatment and Pathogenesis
- Blood disorders and treatments
- Immunodeficiency and Autoimmune Disorders
- Mast cells and histamine
- Immune Response and Inflammation
- Chemokine receptors and signaling
- Immune cells in cancer
- Inflammasome and immune disorders
- Gut microbiota and health
- 14-3-3 protein interactions
- Allergic Rhinitis and Sensitization
- Anesthesia and Neurotoxicity Research
- Cerebral Palsy and Movement Disorders
- Infant Development and Preterm Care
- Autophagy in Disease and Therapy
Kōchi University
2014-2022
John Wiley & Sons (United States)
2017
Wake Forest University
2017
Forest Institute
2017
Centre Hospitalier de l’Université de Montréal
2008-2013
Université de Montréal
2008-2012
Hôpital Notre-Dame
2006-2012
Kagawa University Hospital
2008
RIKEN Center for Integrative Medical Sciences
2006
Abstract Thymus-derived CD4+ CD25+ T regulatory cells (Tregs) are essential for the maintenance of self-tolerance. What critical factors and conditions required extra-thymic development Tregs remains an important question. In this study, we show that anti-inflammatory extracellular matrix protein, thrombospondin-1, promoted generation human peripheral through ligation one its receptor, CD47. CD47 stimulation by mAb or a thrombospondin-1 peptide induced naive memory CD4+CD25− to become...
Abstract Dendritic cells (DCs) orchestrate the immune response establishing immunity versus tolerance. These two opposite functions may be dictated by DC maturation status with maturity linked to immunogenicity. DCs directly interact trillions of noninvasive intestinal bacteria in vivo, a process that contributes gut homeostasis. We here evaluated program elicited human direct exposure commensal-related (CB) absence inflammatory signals. showed eight gram+ and gram− CB strains up-regulated...
Th17 cells are implicated in host defence and autoimmune diseases. CD28/B7 co-stimulation is involved the induction progression of diseases, but its role controlling murine cell fate remains to be clarified. We here report that soluble anti-CD28 mAb suppressed differentiation anti-CD3-stimulated naïve CD4+ T into IL-17-producing cells. CD28 reduced frequency proliferating produce IL-17. provide evidence for an IL-2 IFN-γ-dependent mechanism CD28-mediated IL-17 suppression. blockade...
The biological effects of indium-tin-oxide (ITO) are considerable importance because workers exposed to indium compounds have been diagnosed with interstitial lung disease or pulmonary alveolar proteinosis; however, the pathophysiology these diseases is undefined. Here, mice intraperitoneally inoculated ITO-nanoparticles (ITO-NPs) resulted in peritonitis dependent NLRP3 inflammasome, neutrophils recruitment and interleukin-1β (IL-1β) production. Withal peritoneal macrophages ex vivo ITO-NPs...
Abstract Background Although the contribution of basophils as inducers or amplifiers T h2 responses is still debated, prolonged basophil/ CD 4 cell interactions were observed in lungs but not lymph nodes ( LN s) parasite‐infected mice. However, impact on function tissue effector cells remains unknown. Methods Basophils purified from ovalbumin OVA )‐sensitized and ‐challenged ‐immunized) mice human peripheral blood for vivo vitro functional studies. Pulmonary adoptively transferred to...
In mice, the transfer of CD172a(+) (SIRP-α) dendritic cells (DCs) elicits T cell-driven colitis, whereas treatment with CD47-Fc protein, a CD172a-binding agent, confers protection. The aim this study was to elucidate nature and functional properties human DCs in chronic intestinal inflammation. Here, we show that CD172a(+)CD11c(+) accumulate mesenteric lymph nodes (mLNs) inflamed mucosa patients Crohn's disease (CD). These are distinct from resident may coexpress markers typically associated...
Enteric infections remain a major health problem causing millions of deaths in developing countries. The interplay among the host intestinal epithelium, mucosa-associated immune system and microbiota performs an essential role gut homeostasis protection against infectious diseases. Dendritic cells (DCs) play key orchestrating protective immunity tolerance gut. mechanisms by which DCs adapt their responses discriminate between virulent microbes trillions innocuous bacteria ill-defined. Here...
Neonatal hypoxia-ischemia induces massive brain damage during the perinatal period, resulting in long-term consequences to central nervous system structural and functional maturation. Although neural progenitor cells (NPCs) migrate through parenchyma home injury sites rodent brain, molecular mechanisms are unknown. We examined role of chemokines mediating NPC migration after neonatal hypoxic-ischemic injury.Nine-day-old mice were exposed a 120-minute hypoxia following unilateral carotid...
T cell memory is the hallmark of adaptive immunity. Central questions are to determine which cells among proliferating effector will live beyond crash immune response (IR) and develop into functional cells. CD47, considered as a marker self, implicated in death, elimination, inflammatory response. We report this article that CD47 expression was transiently regulated on Ag-specific CD4 cells, is, from CD47(high) CD47(low) CD47(high), during course vivo IR. Specifically, status marked central...
How do effector CD4 T cells escape cell death during the contraction of immune response (IR) remain largely unknown. CD47, through interactions with thrombospondin-1 (TSP-1) and SIRP-α, is implicated in phagocytosis malignant cells. Here, we reported a reduction SIRP-α-Fc binding to memory (TEM) vitro TCR-activated human that was linked TSP-1/CD47-induced death. The reduced (CD47low status) not detected when were stained two anti-CD47 mAbs, which recognize distinct epitopes. In contrast,...
Abstract Human Slan DCs have been studied in patients with psoriasis, rheumatoid arthritis, cancer, and autoimmune diseases. In this study, we investigated the frequency, phenotype, function of blood, colon, as well mLNs IBD. We first show that frequency circulating CD14dullSlan was reduced CD refractory to immunosuppressive drugs or TNF-α blockers relative untreated CD, UC, healthy subjects. blood patients, expressed CD172a, detected by CD47 fusion protein binding, when compared its lack...
Regenerative medicine using umbilical cord blood (UCB) cells shows promise for the treatment of cerebral palsy. Although efficacy this therapy has been seen in clinic, mechanisms by which UCB interact and aid improvement symptoms are not clear. We explored chemokine expression profile damaged brain tissue neonatal mouse ischemia-reperfusion (IR) injury model that was infused with human (hUCB) cells. IR induced 9-day-old NOD/SCID mice. hUCB were administered 3 weeks post injury. Chemokine...
Evans syndrome is a rare autoimmune disorder with unknown aetiology. Although corticosteroids and/or intravenous immunoglobulin (IVIG) are commonly used in its treatment, no standard strategy has been established. We report here 44-year-old male refractory combined systemic lupus erythematosus (SLE) who responded well to rituximab. He was admitted our hospital severe bleeding caused by worsening of syndrome. Despite treatment high-dose corticosteroid and IVIG, his thrombocytopaenia...
The balance between effector CD4(+) T cells secreting IL-17 (T(h)17) and regulatory (Treg) plays an important role in autoimmune disorders that include rheumatoid arthritis (RA) Crohn's disease. Tumor necrosis factor (TNF)-alpha is a key pro-inflammatory cytokine contributes to disease pathogenesis. We investigated the interplay CD45RA(+) Treg TNF-alpha regulation of human T(h)17 differentiation. found promoted while inhibited naive T-cell differentiation into CCL20 co-expressing without...
Objective: Neonatal hypoxic-ischemic encephalopathy (HIE) is caused by brain injury that occurs in a developing fetus or infant. Stem cell transplantation can reportedly induce functional recovery animal models of HIE. Murine neonatal splenocytes are enriched with immature blood stem cells and used for the investigation murine syngeneic transplantation. The aim this study was to investigate therapeutic potential newborn model ischemia-reperfusion injury.
Abstract To execute a memory program, CD4 effector T cells must escape cell death and elimination survive beyond the contraction of immune response (IR). The involvement Fas/FasL in crash IR has been challenged appeared to occur independently caspase activation. We report here that vitro TCR-activated human ex vivo isolated displayed CD47low status was linked thrombospondin-1/CD47-induced caspase-independent death. By contrast, CD47highstatus observed on central activated cultured presence...