A5015101528- Birth, Development, and Health
- Pregnancy and preeclampsia studies
- Neurological Disorders and Treatments
- Circadian rhythm and melatonin
- Medical and Biological Sciences
- Human Health and Disease
- Mesenchymal stem cell research
- Urological Disorders and Treatments
- Sinusitis and nasal conditions
- Neurological Disease Mechanisms and Treatments
- Neonatal Respiratory Health Research
- Seaweed-derived Bioactive Compounds
- Gestational Diabetes Research and Management
- Empathy and Medical Education
- Alzheimer's disease research and treatments
- Inflammation biomarkers and pathways
- Mitochondrial Function and Pathology
- Oral Health Pathology and Treatment
- Nutrition, Genetics, and Disease
- Digestive system and related health
- Lymphadenopathy Diagnosis and Analysis
- Biomarkers in Disease Mechanisms
- Biochemical effects in animals
- Dermatological and COVID-19 studies
- Adipose Tissue and Metabolism
Kharkiv National Medical University
2011-2025
Kharkov Technologies
2018
National Academy of Medical Sciences of Ukraine
2003
Pskov State University
1996
The article continues the series of lectures by outstanding Kharkiv scientist with a world name, Vasyl Yakovych Danylevskyi. In it, notes that in second half last century, doctor's horizons expanded significantly realization need for social service medicine. order to take into account, patient's ties his diagnosis and treatment, doctor needs knowledge field sociology, psychology, economics, other sciences fields knowledge. A large crowd is dangerous if its psyche set on destruction. public...
In his lecture for first-year medical students in the early 20th century, prominent scientist Vasyl Yakovych Danylevskyi shared views on education and its reform with future physicians. The author noted that while ancient medicine had a mystical character, training of century physicians was conducted exclusively through intellectual means. However, according to Danylevskyi, such remained imperfect closely tied school education. this case, primary task develop capacity serious systematic...
The safety of food additives E407 and E407a has raised concerns in the scientific community. Thus, this study aims to assess local systemic toxic effects common additive rats orally exposed it for two weeks. Complex evaluations semi-refined carrageenan (E407a) on upon oral exposure were performed. Local intestine analyzed using routine histological stains CD68 immunostaining. Furthermore, circulating levels inflammatory markers assessed. A fluorescent probe O1O (2-...
Objective. To determine the morphometric differences in minor buccal salivary glands rats aged 6 months with fetal macrosomia (groups under study) and after a normal intrauterine development (control group) by using 3-D analysis technique. Methods. The was induced four different ways. apply morphological analysis, tissues of oral cavity mucosa six-month-old were used. images acquired confocal microscopy used for estimating morphometrical characteristics gland microscopic structures. Results....
Aim: To evaluate the effects of orally administered gadolinium orthovanadate GdVO4:Eu3+ nanoparticles (VNPs) on course chronic carrageenan-induced intestinal inflammation. Methods: Samples small tissue were collected from four groups rats (intact, after administration VNPs, with carrageenaninduced inflammation, inflammation exposed to VNPs) assess morphology and HSP90α expression. Levels seromucoid, C-reactive protein, TNF-α, IL-1β IL-10 determined in blood serum. Results: Oral exposure VNPs...
Gadolinium orthovanadate GdVO4:Eu3+ nanoparticles (VNPs) have been shown to scavenge reactive oxygen species (ROS), making them a promising therapeutic agent in inflammation. This study aims assess the effects of VNPs administered orally on E407a-induced Materials and Methods: Fragments small intestine 8 rats treated with carrageenan-containing food additive E407a at dose 140 mg / kg weight during 2 weeks, animals exposed both 20 μg same period time, control were stained routinely...
The purpose. To study localization of bone marrow mesenchymal stem cells (BM MSC), labeled by green (DiO C18) and red (Rhod Chol) vital fluorochromes, after intravenous (IV) intracerebral (IC) transplantation into rats with modeled Parkinson-like syndrome (PS).Materials methods. animals were divided 3 groups, each 6: I — control, IV IC administration BM MSC; II PS model III MSC. Cell was performed on the 7th day modeling. MSCs effectiveness assessed decrease motor disorders degree,...
Diseases that manifest in adult life are largely "pre-programmed" already utero. Fetal macrosomia defined as a body weight at birth of 4.000 grams or more is condition associated with range immediate and long-term consequences. Objective. This study focused on determining the indicators collagen metabolism exchange micro- macroelements blood serum experimental animals born macrosomic. The aim to establish if any prognostic markers for emergence dental disorders can be found. Material...
Abstract Objective. The aim of the study was to evaluate vimentin expression in inflamed nasal mucosa patients with chronic rhinosinusitis without polyps (CRSsNP) and serum levels matrix metalloproteinase-9 (MMP-9). Material Methods. We measured concentrations MMP-9 blood twenty CRSsNP using ELISA compared them control group composed healthy subjects. Vimentin studied by an immunohistochemical method. Results. Blood were found be elevated CRSsNP. disease also associated upregulation both...
The purpose: to study efficacy of intravenous injection human and rat bone marrow mesenchymal stem cells (BMMSC) in rats with Parkinson-like syndrome (PS), modeled by chemical degradation substantia nigra (SN).Materials methods. Animals were divided into 5 groups: I — intact (n=7); II PS, bilateral 6-OHDA SN (n=15); III BMMSC (0.5x106 per 1 rat) (n=9); IV (1x106) V (2x106) (n=9). Cells injected 2 weeks after PS modelling. Efficacy was estimated recovery movements, changes dopamine level...
The article analyzes experimental data of histological examination soft tissues rabbits in the foreign body area after different types wounds dynamics. effect temperature factor on features regeneration connective tissue structures capsule is shown. Histological changes case a vicious loop maturation are detailed.
We examined the histological features of mucobuccal fold oral cavity mucous membrane from area masticatory teeth roots’ projection in 6-month-old Wistar Albino Glaxo rats with fetal macrosomia. The animals were divided into groups according to body weight, length, and Quetelet index at birth. A morphological study was performed using Leica SP8 AOBS laser scanning confocal microscope a conventional light (Axiostar, Zeiss) microscopy. Morphometric parameters used estimate degree acanthosis...
Objective: To evaluate of the microstructure salivary glands experimental animals born from females rats, who were subjected to different modes motor activity during pregnancy: limited and compensated by regular moderate training. Material Methods: The sample was composed 84 three-month-old descendants Wistar rats which divided into three groups: G1 (n = 27): posterity female gestation in standard conditions; G2 25): pregnancy hypokinesia G3 32): stayed conditions hypokinesia, but had...
The article presents the results of experimental modeling superficial fragment gunshot wounds soft tissues, obtained in low-energy wounds. pathomorphosis was studied, and features timing their healing were compared depending on temperature damaging fragments. aim work to study effect injuring shrapnel processes tissues animals with superficial Using random number method, laboratory (rabbits) divided into 3 groups (15 each). In each group, wounding fragments different temperatures − 18°С,...
Objective. The aim of this study was to assess the vascular endothelium morphofunctional state brain microcirculatory bed in rats with nitrite-induced Alzheimer's type dementia on background stem cells administration. Methods. 14 days after experiment's end, endothelin-1, VEGF-A, eNOS, von Willebrand factor were determined blood serum by enzyme immunoassay and photometric methods a model (14 28 sodium nitrite intraperitoneal introduction) without mesenchymal (MSCs) slices stained according...