A5101654033- Bone and Joint Diseases
- Cancer-related molecular mechanisms research
- Osteoarthritis Treatment and Mechanisms
- Medical Research and Treatments
- Spine and Intervertebral Disc Pathology
- Bone health and treatments
- Musculoskeletal pain and rehabilitation
- Ion channel regulation and function
- RNA Research and Splicing
- Viral Infections and Vectors
- Medicinal Plant Pharmacodynamics Research
- Viral Infections and Outbreaks Research
- Pediatric health and respiratory diseases
- Respiratory and Cough-Related Research
- Sarcoma Diagnosis and Treatment
- Acupuncture Treatment Research Studies
- Traditional Chinese Medicine Analysis
- Total Knee Arthroplasty Outcomes
- Erythrocyte Function and Pathophysiology
- Ion Transport and Channel Regulation
- Bone Metabolism and Diseases
- Cytokine Signaling Pathways and Interactions
- Pain Mechanisms and Treatments
- Hematological disorders and diagnostics
- Microbial infections and disease research
Wuhan University
2012-2022
Renmin Hospital of Wuhan University
2012-2022
Nanjing Municipal Center for Disease Control And Prevention
2011
Michigan State University
2008
Hebei North University
2006-2007
Shanghai Xuhui Central Hospital
2005
Accumulating evidence has indicated that erythropoietin (EPO) plays a role in anti-apoptosis and tissue protection number of human diseases. The present study was implemented to evaluate these anti-apoptotic tissue-protective effects glucocorticoid-induced osteonecrosis rats. Osteonecrosis induced by low-dose lipopolysaccharide subsequent high-dose methylprednisolone pulse. Rats the preventive group were treated with 500 U/kg/day recombinant EPO (rhuEPO) for 1 week. Hematological...
In this study, the pathological microvessel changes to endplate and degeneration of intervertebral disc diabetic rats were examined in order identify possible mechanism by which diabetes mellitus (DM) induces degeneration disc. A total 30 Sprague-Dawley randomly divided into two groups. DM was induced one groups streptozotocin (STZ) administration. The sacrificed 4, 8 12 weeks later. Five from each group at time interval lumbar tissue obtained rat. histological changes, collagen expression,...
This study was designed to investigate the effects of pulsed electromagnetic fields (PEMF) on balance adipogenesis and osteogenesis steroid‐induced osteonecrosis femoral head (OFH) in rats. Forty‐two rats were divided into three groups: Steroid group (S, n = 16); + PEMF (S P, Control (C, 10). For groups S all first intravenously given 10 µg/kg lipopolysaccharide day 1, then intramuscularly injected with 20 mg/kg methylprednisolone acetate days 2, 3, 4, an interval 24 h. After 4 weeks, P...
Osteosarcoma is the most common primary malignant tumor of skeletal system and characterized by an aggressive clinical course high metastatic potential. Regulated upon Activation Normal T cell Expressed Secreted, also termed C‑C motif chemokine ligand 5 (CCL5), associated with metastasis poor prognosis in various types cancer. The aim current study was to investigate association between CCL5 expression clinicopathological features patients osteosarcoma. Tissue microarrays reverse...
The aim of this study was to determine the relationship hypoxia-inducible factor-2 (HIF-2α) and vascular endothelial growth factor (VEGF) with radiographic severity in primary osteoarthritis (OA) knee. Expression these two factors cartilage samples from OA knee joints examined at mRNA protein levels. Knee were using plain radiographs, assessed Kellgren Lawrence (KL) grading system. Specimens collected 29 patients (31 knees) who underwent total replacement because severe medial (KL grades 3...
// Haohuan Li 1 , Xiaolong Zhang Yiping Cao 2 Song Hu 3 Fei Peng Jianlin Zhou and Jianping Department of Orthopedics, Renmin Hospital Wuhan University, Wuhan, 430060, China Key Laboratory Optoelectronic Chemical Materials Devices, Ministry Education, Jianghan 430056, Physiology, Medical College, Correspondence to: Li, email: lihaohuan@whu.edu.cn Keywords: osteoarthritis, EN1, polymorphism, BMD, case-control Received: November 08, 2016 Accepted: March 10, 2017 Published: April 05, ABSTRACT...
Transmembrane protein 206 (TMEM206), a proton-activated chloride channel, has been implicated in various biochemical processes, including bone metabolism, and emerged as novel cancer-related multiple tumor types. However, its role primary malignant tumors, particularly osteosarcoma (OS), remains unclear. This study is aimed at exploring the effects of TMEM206 gene silencing on proliferation, migration, invasion, metastasis human OS cells vitro vivo using an shRNA-knockdown strategy. We found...
Osteosarcoma is the most common malignant bone tumor. Chloride (Cl − ) channels-mediated Cl movement plays an important role in regulating functions of various cancer cells, but its osteosarcoma remains unclear. In this study, we found that ClC-5 was increased tissues compared with normal tissues. Patients high expression showed poor overall survival relative to those patients low expression. Higher and lower intracellular concentration ([Cl ] i were observed cells osteoblasts. Lowering [Cl...
Osteoarthritis (OA), one of the most common joint disorders, is characterized by chronic progressive cartilage degradation, osteophyte formation, and synovial inflammation. OA lesions are not only located in articular but also entire joint. Nevertheless, early studies done mostly focused on important role chondrocyte apoptosis degeneration pathogenesis progress OA. The increased expression hypoxia-inducible factors (HIF-1α HIF-2α) known to be cellular biochemical signal that mediates...