A5101823658- Ion Transport and Channel Regulation
- Animal Virus Infections Studies
- Immune cells in cancer
- Physiological and biochemical adaptations
- MicroRNA in disease regulation
- Circular RNAs in diseases
- Liver Disease Diagnosis and Treatment
- Epigenetics and DNA Methylation
- Extracellular vesicles in disease
- Autophagy in Disease and Therapy
- Neonatal Respiratory Health Research
- Immune Response and Inflammation
- Cell Adhesion Molecules Research
- RNA modifications and cancer
- Caveolin-1 and cellular processes
- Diet and metabolism studies
- Cancer-related molecular mechanisms research
- Viral gastroenteritis research and epidemiology
- Angiogenesis and VEGF in Cancer
- Virus-based gene therapy research
- Heat shock proteins research
- Aquaculture Nutrition and Growth
- HER2/EGFR in Cancer Research
- ATP Synthase and ATPases Research
- Trauma, Hemostasis, Coagulopathy, Resuscitation
Bengbu Medical College
2019-2024
Huazhong Agricultural University
2013-2022
Shantou University
2021
Intercellular adhesion molecule-1 is the molecule mediating leukocyte firm to endothelial cells, plays a critical role in subsequent transmigration. ICAM-1 also expressed other cells including macrophages; however, of this macrophage functions remains enigmatic. We report that regulates polarization by positively modulating miR-124 expression. found higher expression levels monocyte chemotactic protein-1 lungs mice lacking ICAM-1. Consistent with result, siRNA mediated depletion resulted...
Autophagy is a process of evolutionarily conservative degradation, which could maintain cellular homeostasis and cope with various types stress. LncRNAs are considered as competing endogenous RNAs (ceRNAs) contributing to autophagy. GAS5 has been suggested new potential factor mediate autophagy pathway the underlying mechanism remains be further confirmed. This study was taken identify effect GAS5/miR-23a/ATG3 axis on cell viability.The western blotting assay used detecte protein levels LC3,...
As the first line of defense against intestinal bacteria and toxins, epithelial cells are always exposed to or lipopolysaccharide (LPS), whereas pathogenic LPS can cause cell damage. Previous studies have shown that konjac mannan oligosaccharides (KMOS) a positive effect on maintaining integrity, Bacillus subtilis (BS) promote barrier intestine. However, it is still unknown whether KMOS BS synergistic protective intestines. In this study, we used LPS-induced Caco-2 injury model mouse study...
Collagen is a major extracellular matrix component playing pivotal roles in maintaining the muscle growth and flesh texture of fish. Enhancement collagen deposition by environmental factors serves as an effective way to improve quality fish products. However, critical factor aquaculture, effects temperature on metabolism are largely unknown. Here, we used zebrafish (Danio rerio) model investigate water (18 ℃, 28 34 ℃) performance, structure metabolism. After 7-week trial, performance density...
Several microRNAs (miRNAs) are known as regulatory molecules involved in gastric tumor metastasis. The expression of miR‑337‑3p was revealed to be downregulated metastatic cells. Overexpression cancer cells resulted the reduction their invasive abilities. To characterize functions miR‑337‑3p, expressed a lymph node‑derived cell line, SGC‑7901. reduced viability but had no effects on cycle. Wound healing and Transwell migration assays that inhibited capacity capable binding 3'‑untranslated...
Intercellular adhesion molecule-1 (ICAM-1) mediates the firm of leukocytes to endothelial cells and initiates subsequent signaling that promotes their transendothelial migration (TEM). Vascular (VE)-cadherin plays a critical role in cell–cell adhesion, thereby controlling permeability leukocyte transmigration. This study aimed determine molecular events originate from ICAM-1–mediated neutrophils regulate VE-cadherin's as negative regulator We observed ICAM-1 interacts with Src homology...
Neutrophils are innate immune cells that play a crucial role in the first line of host defense. It is also known neutrophil lung recruitment and infiltration may cause injury. The roles neutrophils virus infection-induced injury not clear. We explore mechanisms potential biomarkers for swine model caused by natural or experimental porcine reproductive respiratory syndrome (PRRSV) infection. Neutrophil was determined measurement myeloperoxidase expression enzyme activity tissues....
Abstract Lepus yarkandensis is a desert hare of the Tarim Basin in western China, and it has strong adaptability to arid environments. Aquaporins (AQPs) are family water channel proteins that facilitate transmembrane transport. Gastrointestinal tract AQPs involved fluid absorption small intestine colon. This study aimed determine distribution sodium transporters gastrointestinal L. compare expression these with Oryctolagus cuniculus . Immunohistochemistry was performed analyse cellular...
Lepus yarkandensis is a desert-dwelling animal that has various adaptations to cope with drought. The kidney maintains water and acid-base balance mainly through the vasopressin-regulated reabsorption pathway proximal tubular bicarbonate pathway. In this study, we compared differentially expressed genes (DEGs) transcription factors in kidneys of L. Oryctolagus cuniculus explore relationship between DEGs animals’ adaptations. Transcriptome sequencing data were used predict...
To investigate the influence of exposure to high-altitude (HA) hypoxia on expressions endothelin-1 (ET-1), endothelin type A (ETA) and B (ETB) receptors in broiler chickens, immunohistochemistry studies were performed lungs. Six hundred 1-day-old male chickens randomly divided into two groups: group A, birds maintained under rich oxygen conditions (oxygen content 21%); B, exposed HA 13%). Our data showed that altitude elevated ET-1 ETA gene at 21 28 days age when compared with group....
Lepus yarkandensis specifically lives in arid climate with rare precipitation of Tarim Basin western China. Aquaporins (AQPs) are a family channel proteins that facilitate water transportation across cell membranes. Kidney AQPs play vital roles renal tubule permeability and maintenance body homeostasis. This study aimed to investigate whether kidney exhibit higher expression arid-desert living animals. Immunohistochemistry results revealed localization AQP1 the capillary endothelial cells...
Abstract Water transport across epithelial cells that line the airways and alveoli is a crucial component of lung physiology. Aquaporins (AQPs) facilitate water air space–capillary barrier in distal lung. However, roles AQPs desert animal adaptation to dry airstream environments are still unclear. A hare ( Lepus yarkandensis ) only lives Tarim Basin, its living environment an arid climate with rare precipitation. We studied cellular localization expression levels AQP1, AQP3, AQP4 AQP5 L....
Abstract Endogenous miR22 is associated with a diverse range of biological processes through post-translational modification gene expression and its deregulation results in various diseases including cancer. Its usually tissue or cell-specific, however, the reasons behind this cell specificity are not clearly outlined till-date. Therefore, our keen interest was to investigate mechanisms cell-specific miR22. In current study, showed tissues-specific difference poly(I:C) induced inflammatory...