A5002382701- Gastrointestinal disorders and treatments
- Pancreatitis Pathology and Treatment
- IgG4-Related and Inflammatory Diseases
- Estrogen and related hormone effects
- Eosinophilic Esophagitis
- Vitamin C and Antioxidants Research
- Retinoids in leukemia and cellular processes
- Protein Degradation and Inhibitors
- Ubiquitin and proteasome pathways
- Multiple Myeloma Research and Treatments
- Reproductive Biology and Fertility
- Immune Cell Function and Interaction
- Reproductive Health and Technologies
- IL-33, ST2, and ILC Pathways
- Sperm and Testicular Function
- Galectins and Cancer Biology
University Medical Center Hamburg-Eppendorf
2016
Universität Hamburg
2016
University of Lübeck
2011-2015
University of Rostock
2011
Abstract Type 2 innate lymphoid cells (ILC2) mediate inflammatory immune responses in the context of diseases triggered by alarmin IL-33. In recent years, IL-33 has been implicated pathogenesis immune-mediated liver diseases. However, immunoregulatory function ILC2s inflamed remains elusive. Using murine model Con A–induced hepatitis, we showed that selective expansion was associated with highly elevated hepatic expression, severe inflammation, and infiltration eosinophils. CD4+ T...
<h3>Background and aims</h3> Autoimmune pancreatitis (AIP) represents a rare but clinically relevant cause of pancreatic inflammation. Using MRL/Mp mice as model spontaneous AIP, the genetic basis disease was studied. <h3>Methods</h3> To identify quantitative trait loci (QTL) an advanced intercross line studied, originating from MRL/MpJ parental following three mouse strains: Cast (healthy controls), BXD2 (susceptible to collagen induced arthritis), NZM (a lupus erythematosus). This concept...
The mouse strain MRL/MpJ is prone to spontaneously develop autoimmune pancreatitis (AIP). To elucidate the genetic control towards development of phenotype and characterize contributions immunocompetent cell types, mice were interbred with three additional strains (BXD2/TYJ, NZM2410/J, CAST/EIJ) for four generations in an advanced intercross line. Cellular phenotypes determined by flow cytometric quantification splenic leukocytes complemented histopathological evaluation pancreatic lesions....
A large proportion of ovine oocytes fail to develop into viable embryos following maturation, fertilization, and culture in vitro. Accurate, fast, noninvasive predictors oocyte quality are therefore urgent need for selection before vitro maturation (IVM). Recent studies have shown that competence can be predicted through the presence glucose-6-phosphate dehydrogenase (G6PD) enzyme, as indicated by brilliant cresyl blue (BCB), a dye degraded G6PD. Thus, completed their growth phase show...