A5021620872- Hepatocellular Carcinoma Treatment and Prognosis
- Liver physiology and pathology
- Cancer therapeutics and mechanisms
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Virus-based gene therapy research
- Cancer Genomics and Diagnostics
- RNA modifications and cancer
- Genetic Syndromes and Imprinting
- Parvovirus B19 Infection Studies
- Pancreatic and Hepatic Oncology Research
- Liver Disease Diagnosis and Treatment
- Viral Infections and Immunology Research
- Plant Genetic and Mutation Studies
- Epigenetics and DNA Methylation
- Xenotransplantation and immune response
- Hepatitis B Virus Studies
- ATP Synthase and ATPases Research
Centre de Recherche des Cordeliers
2019-2024
Université Paris Cité
2019-2024
Sorbonne Université
2019-2024
Inserm
2019-2024
La Ligue Contre le Cancer
2024
Assistance Publique – Hôpitaux de Paris
2024
Rockefeller University
2021
Sorbonne Paris Cité
2019
Génomique Fonctionnelle des Tumeurs Solides
2019
Heidelberg University
2018
Background and aimsHepatocellular carcinomas (HCCs) are heterogeneous aggressive tumors with low rates of response to treatment at advanced stages. We screened a large panel liver cancer cell lines (LCCLs) identify agents that might be effective against HCC markers therapeutic response.MethodsWe performed whole-exome RNA microRNA sequencing quantification 126 proteins in 34 LCCLs. 31 anticancer for their ability decrease viability. compared genetic, RNA, protein profiles LCCLs those primary...
Abstract Pediatric liver cancers (PLC) comprise diverse diseases affecting infants, children, and adolescents. Despite overall good prognosis, PLCs display heterogeneous response to chemotherapy. Integrated genomic analysis of 126 pediatric tumors showed a continuum driver mechanisms associated with patient age, including new targetable oncogenes. In 10% patients hepatoblastoma, all before three years old, we identified mosaic premalignant clonal expansion cells altered at the 11p15.5 locus....
Hepatoblastoma (HB) is the most common liver cancer in children. We aimed to characterize HB related APC (Adenomatous Polyposis Coli) germline mutation (APC-HB). This French multicentric retrospective study included 12 APC-HB patients under 5 at diagnosis. Clinical features of were compared SIOPEL2-3 cohort patients. Molecular and histopathological analyses 15 consecutive sporadic treated Bicêtre hospital from 2013 2015 (non-APC-HB). have a peculiar spectrum mutations, with no events main...
Hepatoblastoma is the most frequent pediatric liver cancer. The current treatments lead to 80% of survival rate at 5 years. In this study, we evaluated clinical relevance molecular features identify patients risk chemoresistance, relapse and death disease.
Abstract Pediatric liver tumors are very rare with the most common diagnosis being hepatoblastoma. While hepatoblastomas predominantly sporadic, around 15% of cases develop as part predisposition syndromes such Beckwith-Wiedemann (11p15.5 locus altered). Here, we identify mosaic genetic alterations 11p15.5 in hepatoblastoma patients without a clinical syndrome. We do not retrieve these children other types pediatric tumors. show that FFPE sections display IGF2 overexpression and H19...
Single nucleotide changes were introduced into the non-structural (NS) coding sequence of H-1 parvovirus (PV) infectious molecular clone and corresponding virus stocks produced, thereby generating H1-PM-I, H1-PM-II, H1-PM-III, H1-DM. The effects mutations on viral fitness analyzed. Because overlapping sequences NS1 NS2, affected either NS2 (H1-PM-II, -III) or both proteins (H1-PM-I, H1-DM). Our results show key benefits PM-I, PM-II, DM with regard to produced. Indeed, these mutants displayed...
Hepatocellular carcinoma (HCC) patient-derived xenograft (PDX) models hold potential to advance knowledge in HCC biology help improve systemic therapies. Beside hepatitis B virus-associated tumors, is poorly established PDX.PDX formation from fresh biopsies were obtained and implanted intrahepatically or subrenal capsule (SRC). Mouse liver injury was induced immunodeficient Fah-/- mice through cycling off nitisinone after biopsy implantation, versus continuous as non-liver controls. Mice...
<div>Abstract<p>Pediatric liver cancers (PLC) comprise diverse diseases affecting infants, children, and adolescents. Despite overall good prognosis, PLCs display heterogeneous response to chemotherapy. Integrated genomic analysis of 126 pediatric tumors showed a continuum driver mechanisms associated with patient age, including new targetable oncogenes. In 10% patients hepatoblastoma, all before three years old, we identified mosaic premalignant clonal expansion cells altered at...
<p>All 17 supplementary figures and legends in a pdf file</p>
<p>All 17 supplementary figures and legends in a pdf file</p>
<div>Abstract<p>Pediatric liver cancers (PLC) comprise diverse diseases affecting infants, children, and adolescents. Despite overall good prognosis, PLCs display heterogeneous response to chemotherapy. Integrated genomic analysis of 126 pediatric tumors showed a continuum driver mechanisms associated with patient age, including new targetable oncogenes. In 10% patients hepatoblastoma, all before three years old, we identified mosaic premalignant clonal expansion cells altered at...