A5101789112- Fractal and DNA sequence analysis
- Machine Learning in Bioinformatics
- RNA and protein synthesis mechanisms
- Research on Leishmaniasis Studies
- Electrospun Nanofibers in Biomedical Applications
- 3D Printing in Biomedical Research
- Vaccine Coverage and Hesitancy
- Bone Tissue Engineering Materials
- Genomics and Phylogenetic Studies
- RNA modifications and cancer
- Microfluidic and Bio-sensing Technologies
- Silk-based biomaterials and applications
- Cancer, Hypoxia, and Metabolism
- Alzheimer's disease research and treatments
- Graphene and Nanomaterials Applications
- Helicobacter pylori-related gastroenterology studies
- Neuroscience and Neural Engineering
- T-cell and B-cell Immunology
- Peptidase Inhibition and Analysis
- Cancer-related gene regulation
- Tissue Engineering and Regenerative Medicine
- Body Composition Measurement Techniques
- Gene expression and cancer classification
- Vitamin C and Antioxidants Research
- Inflammatory Biomarkers in Disease Prognosis
Gauhati University
2025
Texas A&M University
2023-2024
Mawlana Bhashani Science and Technology University
2024
Indian Institute of Technology Kharagpur
2010-2024
Fakir Mohan University
2024
Odisha University of Technology and Research
2023
Indian Institute of Chemical Biology
1999-2023
Indian Institute of Science Bangalore
2015-2023
Council of Scientific and Industrial Research
2023
KIIT University
2017-2022
OBJECTIVE To use the findings of a systematic review scientific evidence to develop consensus guidelines on nonmedical interventions that address cognitive function and core deficits in children with autism spectrum disorders (ASDs) recommend priorities for future research. METHODS The were developed by Technical Expert Panel (TEP) consisting practitioners, researchers, parents. A overview research was presented TEP; guideline statements drafted, discussed, debated, edited, reassessed,...
Abstract Alloreactive T lymphocytes can be primed through direct presentation of donor MHC:peptide complexes on graft cells and indirect donor-derived determinants expressed by recipient APCs. The large numbers an allograft the high frequency alloreactive repertoire has further led to speculation that exposure environmental Ags may prime cross-react with alloantigens. We sought develop a model in which test this hypothesis. found CD4+ obtained from C57BL/6 (B6) mice clinically resolved...
Unique two-dimensional water channels formed by stacked graphene oxide (GO) sheets that are "nonleachable" and nonswellable can show great potential for remediation. The interlayer spacing controls the solute or ion sieving plays a crucial role in transport GO-based membranes. Herein, sub-nano-channels adjacent to altered either ionic covalent cross-linking using magnesium hydroxide (Mg(OH)2) quantum dots (GQDs) (named GOM G-GQD), respectively. In aqueous solution, these cross-linkers...
Abstract The virulence of Leishmania donovani in mammals depends at least part on cysteine proteases because they play a key role CD4+ T cell differentiation. A 6-fold increase NO production was observed with 0.5 μM chicken cystatin, natural protease inhibitor, IFN-γ-activated macrophages. In 45-day BALB/c mouse model visceral leishmaniasis, complete elimination spleen parasite burden achieved by cystatin synergistic activation suboptimal dose IFN-γ. contrast to the case promastigotes, and...
Abstract TGF-β signaling is critical for controlling naive T cell homeostasis and differentiation; however, the biological biochemical changes induced by in effector/memory cells are poorly defined. We show that although inhibits peripheral blood lymphoblast proliferation IL-2 production, intensity kinetics TCR-induced global tyrosine phosphorylation markedly increased compared with untreated or cells. After TCR ligation, of proximal kinases docking proteins like linker activation maintained...
Abstract The tumor microenvironment (TME) promotes angiogenesis for its growth through the recruitment of multiple cells and signaling mechanisms. For example, TME actively recruits activates platelets from microcirculation to facilitate metastasis, but may simultaneously also support angiogenesis. Here, model this complex pathophysiology within that involves a triad cancer cells, sprouting endothelial platelets, an angiogenesis‐enabled chip (aTME‐Chip) is presented. This platform...
Active targeting of doxorubicin to macrophages was studied by incorporating it in mannose-coated liposomes use visceral leishmaniasis BALB/c mice as the model macrophage disease. Mannosylated liposomal more effective than or free doxorubicin. Because is accompanied immunosuppression, immunostimulation interferon (IFN)—γ evaluated act synergistically with mannosylated therapy. Combination chemotherapy a suboptimal dose IFN-γ resulted possibly complete elimination spleen parasite burden....
Bronchiectasis not related to cystic fibrosis is common in indigenous populations globally, but it has been studied Canadian children.The objective of this study was describe bronchiectasis Inuit children and examine potentially causal factors.We described the clinical features residing Qikiqtani (Baffin) Region, Nunavut, Canada, by performing a retrospective chart review from region. Patients had computed tomography-confirmed were diagnosed at Children's Hospital Eastern Ontario, Ottawa,...
Polymeric architectures with controlled and well-defined structural features render a sustainable antibacterial surface — key requirement in the design of polymeric membranes for water purification.
Cervical cancer is the second most common female worldwide and a disease of concern due to its high rate incidence about 500,000 women annually responsible for 280,000 deaths in year. The mortality morbidity cervical are reduced through mass screening via Pap smear, but this technique suffers from very false negativity around 30% 40% hence sensitivity not more than 60%. Electrical bioimpedance study employing cytosensors over frequency range offers instantaneous quantitative means monitor...
Helicobacter pylori induces the antiapoptotic protein myeloid cell leukemia 1 (Mcl1) in human gastric epithelial cells (GECs). Apoptosis of oncogenic Mcl1-expressing is mainly regulated by Noxa-mediated degradation Mcl1. We wanted to elucidate status Noxa H. pylori-infected GECs. For this, various GECs such as AGS, MKN45, and KATO III were either infected with or left uninfected. The effect infection was examined immunoblotting, immunoprecipitation, chromatin immunoprecipitation assay, vitro...
Helicobacter pylori infection is one of the most potent factors leading to gastric carcinogenesis. The seven in absentia homologue (Siah2) an E3 ubiquitin ligase which has been implicated various cancers but its role H. pylori-mediated carcinogenesis not established. We investigated involvement Siah2 cancer metastasis was assessed by invasiveness and migration pylori-infected epithelial cells. Cultured cells (GCCs) MKN45, AGS Kato III showed significantly induced expression Siah2, increased...
Carbon nanotubes have been explored in various fields of science and technology due to their unique properties. However, toxic nature put limitations its consideration for the bio-medical applications. In our work, we report synthesis paramagnetic CNT/Gd2O3 hybrid nanostructures through easily scalable electrochemical deposition technique. The nanostructure has shown significant longitudinal relaxivity 18.93 mM−1s−1 water protons indicating possibility be used as an MRI contrast agent....
Carbon dots (CDs) have recently emerged in biomedical and agricultural domains, mainly for their probe applications developing efficient sensors. However, the existing high-temperature approaches limit industrial level scaling up to further translate them into different products by mass-scale fabrication of CDs. To address this, we attempted lower synthesis temperature 140 °C synthesized CDs using organic acids combinations a one-step approach (quantum yield 3.6% 16.5%; average size 3 5 nm)....
Active targeting of CpG-containing oligodeoxynucleotide (CpG-ODN) to macrophages was studied by incorporating it in mannose-coated liposomes, using visceral leishmaniasis as the model macrophage disease. Mannosylated liposomal CpG-ODN more effective than or free inhibiting amastigote multiplication within macrophages. Moreover, a 60-day mouse leishmaniasis, complete elimination spleen parasite burden achieved mannosylated CpG-ODN, compared 62% and 81% suppression ODN, respectively, at...
A parasite-specific 51-kDa protein has been isolated from the membrane of macrophages infected with Leishmania donovani, causative agent visceral leishmaniasis. Active targeting doxorubicin to was studied by incorporating it in immunoliposomes prepared grafting F(ab)'(2) anti-51-kDa antibody onto liposomal surface. In a 45-day mouse model leishmaniasis, complete elimination spleen parasite burden achieved incorporated immunoliposome (immunodoxosome) at dose 250 microg/kg/day that given for 4...
The array highly efficiently promotes cardiomyogenic commitment of stem cells<italic>via</italic>integrin-mediated signalling compared to the smooth surface and is a potential platform for<italic>ex vivo</italic>differentiation cells for cell therapy in cardiac tissue repair regeneration.