A5008045445- Endometriosis Research and Treatment
- Endometrial and Cervical Cancer Treatments
- Gynecological conditions and treatments
- Nanoplatforms for cancer theranostics
- Advanced Radiotherapy Techniques
- Hepatocellular Carcinoma Treatment and Prognosis
- Cancer Research and Treatments
- Mitochondrial Function and Pathology
- Cancer Immunotherapy and Biomarkers
- Cervical Cancer and HPV Research
- Radiation Therapy and Dosimetry
- Cancer Cells and Metastasis
- ATP Synthase and ATPases Research
- Radiation Dose and Imaging
- Photodynamic Therapy Research Studies
- Galectins and Cancer Biology
- Fuel Cells and Related Materials
- Signaling Pathways in Disease
- Pancreatic and Hepatic Oncology Research
- Cancer, Hypoxia, and Metabolism
- Breast Cancer Treatment Studies
- Ovarian cancer diagnosis and treatment
- Pancreatic function and diabetes
- Photosynthetic Processes and Mechanisms
- Medical Imaging Techniques and Applications
Stanford University
2022-2024
Duke University
2017-2024
National Heart Lung and Blood Institute
2016-2017
National Institutes of Health
2017
Pathological metabolic conditions such as ischemia induce the rupture of mitochondrial envelope and release pro-apoptotic proteins, leading to cell death. At onset this process, inner membrane becomes depolarized permeable osmolytes, proposedly due opening a non-selective protein channel unknown molecular identity. A recent study purports that channel, referred Mitochondrial Permeability Transition Pore (MPTP), is formed within c-subunit ring ATP synthase, upon its dissociation from...
While surgery is at the foundation of cancer treatment, its access limited in low-income countries. Here, we describe development a low-cost alternative therapy based on intratumoral ethanol injection suitable for resource-limited settings. Although ethanol-based tumor ablation successful treating hepatocellular carcinomas, necessity multiple treatments, large fluid volumes, and decreased efficacy treatment non-capsulated tumors limit applicability. To address these limitations, investigated...
Objective: Ethanol ablation, the injection of ethanol to induce necrosis, was originally used treat hepatocellular carcinoma, with survival rates comparable surgery. However, efficacy is limited due leakage into surrounding tissue. To reduce leakage, we previously reported incorporating ethyl cellulose (EC) as this mixture forms a gel when injected further develop EC-ethanol an ablative therapy, present study evaluates extent which salient parameters govern fluid distribution. Methods:...
Focal tumor ablation with ethanol could provide benefits in low-resource settings because of its low overall cost, minimal imaging technology requirements, and acceptable clinical outcomes. Unfortunately, is not commonly utilized a lack predictability the zone, caused by inefficient retention at injection site. To create predictable zone ablation, we have developed polymer-assisted method using ethyl cellulose (EC) mixed ethanol. EC ethanol-soluble water-insoluble, allowing for EC-ethanol to...
Ethanol provides a rapid, low-cost ablative solution for liver tumors with small technological footprint but suffers from uncontrolled diffusion in target tissue, limiting treatment precision and accuracy. Incorporating the gel-forming polymer ethyl cellulose to ethanol localizes distribution. The purpose of this study was establish non-invasive methodology based on CT imaging quantitatively determine relationship between delivery parameters EC-ethanol formulation, its distribution,...
Abstract In low-income countries, up to 80% of women diagnosed with cervical dysplasia do not return for follow-up care, primarily due treatment being inaccessible. Here, we describe development a low-cost, portable suitable such settings. It is based on injection ethyl cellulose (EC)-ethanol ablate the transformation zone around os, site most impacted by dysplasia. EC polymer that sequesters ethanol within prescribed volume when injected into tissue, and this modulated delivery parameters...
Triple-negative breast cancer (TNBC) is an immunologically heterogenous disease that lacks clinically actionable targets and more likely to progress metastatic than other types of cancer. Tumor ablation has been used increase response rates checkpoint inhibitors, which remain low for TNBC patients. We hypothesized tumor could produce anti-tumor without using inhibitors if immunosuppression (i.e., Tregs, acidosis) was subdued. Tumors were primed with sodium bicarbonate (200 mM p.o.) reduce...
Abstract Purpose: Risk prediction with genomic and transcriptomic data has the potential to improve patient outcomes by enabling clinicians identify patients requiring adjuvant treatment approaches, while sparing low-risk from unnecessary interventions. Endometrioid endometrial carcinoma (EEC) is most common cancer in women developed countries, rates of are increasing. Experimental Design: We collected a 105-patient case-control cohort stage I EEC comprising 45 who experienced recurrence...
Ethanol ablation is a minimally invasive, cost-effective method of destroying tumor tissue through an intratumoral injection high concentrations cytotoxic alcohol. Ethyl-cellulose ethanol (ECE) ablation, modified version contains the phase-changing polysaccharide ethyl-cellulose to reduce leakage away from tumor. Ablation produces necrosis and initiates wound healing process; however, characteristic immunologic events after ECE tumors has yet be explored. Models triple-negative breast cancer...
Ethyl cellulose–ethanol (ECE) is emerging as a promising formulation for ablative injections, with more controllable injection distributions than those from traditional liquid ethanol. This study evaluates the influence of salient parameters on forces needed infusion, depot volume, retention, and shape in large animal model relevant to human applications. Experiments were conducted investigate how infusion volume (0.5 mL 2.5 mL), ECE concentration (6% or 12%), needle gauge (22 G 27 G), rate...
<div>AbstractPurpose:<p>Risk prediction with genomic and transcriptomic data has the potential to improve patient outcomes by enabling clinicians identify patients requiring adjuvant treatment approaches, while sparing low-risk from unnecessary interventions. Endometrioid endometrial carcinoma (EEC) is most common cancer in women developed countries, rates of are increasing.</p>Experimental Design:<p>We collected a 105-patient case-control cohort stage I EEC...
<p>Supplemental Figure 1: Kaplan Meier Survival Curves by TCGA Molecular Subtype</p>
<p>Supplemental Figure 4: Recurrence Free Survival stratified by EERI score for Stages I-IV disease in the TCGA-UCEC Cohort. Patients with EEC stage at diagnosis. were included more than 1 year of follow-up and known endometrioid histology. A) Stage I patients. B) II C) III D) IV E) All stages.</p>
<p>Supplemental Figure 2: Schoenfeld’s test of proportional hazards for multivariate Cox analysis including CINSARC and EcoTyper Classifiers.</p>
<p>Supplemental Figure 4: Recurrence Free Survival stratified by EERI score for Stages I-IV disease in the TCGA-UCEC Cohort. Patients with EEC stage at diagnosis. were included more than 1 year of follow-up and known endometrioid histology. A) Stage I patients. B) II C) III D) IV E) All stages.</p>
<p>Supplemental Figure 1: Kaplan Meier Survival Curves by TCGA Molecular Subtype</p>
<p>Supplemental Figure 3: EERI Values in TCGA Subtypes. A) The Stanford-EEC cohort and subgroups. B) TCGA-UCEC P-values generated by Whitney-Mann U test. Error bars represent 95% confidence intervals.</p>
<div>AbstractPurpose:<p>Risk prediction with genomic and transcriptomic data has the potential to improve patient outcomes by enabling clinicians identify patients requiring adjuvant treatment approaches, while sparing low-risk from unnecessary interventions. Endometrioid endometrial carcinoma (EEC) is most common cancer in women developed countries, rates of are increasing.</p>Experimental Design:<p>We collected a 105-patient case-control cohort stage I EEC...
<p>Supplemental Figure 3: EERI Values in TCGA Subtypes. A) The Stanford-EEC cohort and subgroups. B) TCGA-UCEC P-values generated by Whitney-Mann U test. Error bars represent 95% confidence intervals.</p>