A5067180755- Bone Tumor Diagnosis and Treatments
- Hip disorders and treatments
- Sarcoma Diagnosis and Treatment
- Foot and Ankle Surgery
- Oral and Maxillofacial Pathology
- Bone fractures and treatments
- Connective tissue disorders research
- Neurogenetic and Muscular Disorders Research
- Cerebral Palsy and Movement Disorders
- Musculoskeletal synovial abnormalities and treatments
- Botulinum Toxin and Related Neurological Disorders
- Bone health and treatments
- Orthopedic Surgery and Rehabilitation
- Orthopedic Infections and Treatments
- Balance, Gait, and Falls Prevention
- Elbow and Forearm Trauma Treatment
- Orthopaedic implants and arthroplasty
- Shoulder Injury and Treatment
- Hip and Femur Fractures
- Lower Extremity Biomechanics and Pathologies
- Musculoskeletal Disorders and Rehabilitation
- Tracheal and airway disorders
- RNA modifications and cancer
- Dermatological diseases and infestations
- Bone Metabolism and Diseases
Maastricht University
2010-2023
Maastricht University Medical Centre
2010-2022
University Medical Center
2022
Zorginstituut Nederland
2020
GTx (United States)
2019
Orthopedic One
2014-2016
OLVG
2008
Vrije Universiteit Amsterdam
2000
University of Amsterdam
2000
Klaassens M, Reinstein E, Hilhorst‐Hofstee Y, Schrander JJP, Malfait F, Staal H, ten Have LC, Blaauw J, Roggeveen HCJ, Krakow D, De Paepe A, van Steensel MAM, Pals G, Graham JM Jr, Schrander‐Stumpel CTRM. Ehlers–Danlos arthrochalasia types (VIIA–B) – expanding the phenotype: from prenatal life through adulthood. The syndromes (EDS) form a clinically and genetically heterogeneous group of inherited connective‐tissue disorders characterized by joint hypermobility, tissue fragility skin...
In this article, gait data of typically developing (TD) children (24 boys/31 girls, mean (95% confidence interval) age 9.38 (8.51 - 10.25) years, body mass 35.67 (31.40 39.94) kg, leg length 0.73 (0.70 0.76) m, and height 1.41 (1.35 1.46) m) walking at different speeds is shared publicly. Raw processed presented for each child separately includes single step both legs. Beside, the subject demographics results from physical examination are allowing to select TD database create a matched...
Cerebral palsy (CP) may cause severe spasticity, requiring neurosurgical procedures. The most common procedures are continuous infusion of intrathecal baclofen and selective dorsal rhizotomy. Both invasive complex We hypothesized that a percutaneous radiofrequency lesion the root ganglion (RF-DRG) could be simple safe alternative treatment. undertook pilot study to test this hypothesis.We performed an RF-DRG procedure in 17 consecutive CP patients with hip flexor/adductor spasms accompanied...
Purpose Dysplasia epiphysealis hemimelica (DEH) is a rare developmental disorder resulting in epiphyseal overgrowth. Based on histological appearance, it often described as an osteochondroma or osteochondroma-like lesion, although clinical differences exist between DEH and osteochondromas. The aim of this study was to test whether osteochondromas are histologically identical diseases. Methods Tissue samples two age- gender-matched cases with hereditary multiple exostoses were compared....
Background Multiple ostechondromas (MO) is an autosomal dominant inherited disease caused by mutated exostosin genes. It mostly affects the long bones and can lead to growth disturbances, especially disproportionate short stature. Both local effect on plates systemic influence of gene disorder mechanisms might explain diminished Purpose The hypothesis this study that stature in adults with MO due a influence, leading early skeletal maturation closure plate. Therefore, these patients age...
Background. The purpose of this study is to evaluate functional and radiological outcomes subtalar arthroereisis in the treatment symptomatic pediatric flexible flatfeet. Methods. A total 16 patients (26 feet) were treated with a Kalix II as motion blocker between 2009 2014. Calcaneal pitch (CP) Meary’s angle (MA) measured on radiographs preoperatively, directly postoperatively, at follow-up 47 ± 17 (range 19-79) months. Patient satisfaction surveys used assess outcome patient satisfaction....
Instrumented treadmills have become more mainstream in clinical assessment of gait disorders children, and are increasingly being applied as an alternative to overground analysis. Both approaches differ multiple elements set-up (e.g., versus treadmill, Pug-in Gait Human Body Model-II), workflow limited amount steps many successive steps) post-processing data different filter techniques). These individual shown affect gait. Since the used parallel practice, insight into compound effect on is...
Background: Patients with hereditary multiple osteochondromas (HMO) undergo frequent radiographs to evaluate the growth of their osteochondromas. The conventional radiographic images clearly show bony part and direction long bones. do not cartilage cap on top osteochondroma nor they surrounding soft tissue or nearby epiphysis. Alongside these disadvantages taking carries potential risk inducing malignant degeneration through ionizing radiation. In this study we investigated use whole-body MR...
The W/M serrated high tibial osteotomy is a not frequently described surgical technique for simultaneously correcting the varus and torsional deformity in patients with Blount's disease. Without need internal fixation, this treatment well suited developing countries. This study describes short-term results of bilateral unilateral infantile disease.Between May 2008 January 2013, 52 were treated uni- (n = 22) or bi-lateral 30) proximal tibia due to two district hospitals Ghana. Other causes...
Objective The objective of this study is to familial inheritance for Blount disease create better understanding the aetiology disease. Methods After reviewing patient files and conventional roentgenologic imaging, 139 patients with were included in cross-sectional study, which 102 interviewed. During interviews, characteristics family history collected. Blood samples taken from five three families a whole exome sequencing was performed. Results Although came all over country, 90% belonged...
A parry fracture is an isolated of the ulnar shaft. It occurs when ulna receives full force impact forearm raised to protect face. The aim this study assess a possible association between and probability abuse in children. In retrospective, observational, multicenter study, we identified patients 2 16 years old who had been treated for shaft fracture. Patient characteristics were registered, anonymized radiographs rated, charts screened referral child protective team. total 36 analyzed. As...
Medial fractures are the least common type of clavicular fracture (2-10%). The patient is a 29-year-old gynaecology resident with hyper-laxity and sternoclavicular instability. latter had been surgically stabilized Dacron((R)) tape, which eroded bone causing an usura. Acute right shoulder pain occurred 10 years later. CT revealed medial stress fracture. After 4 weeks conservative management, internal fixation followed. Five months postoperatively performed all activities without pain. In...
Ribosome biogenesis is integrated with many cellular processes including proliferation, differentiation and oncogenic events. Chondrogenic proliferation require a high translational capacity to facilitate cartilaginous extracellular matrix production. We here investigated the expression dynamics of factors involved in ribosome during vitro chondrogenic determined whether protein translation adapts different phases differentiation.SnoRNA ATDC5 was analyzed by RNA sequencing samples acquired...
Isolated macrodactyly in adults caused by mosaic pattern PIK3CA mutation can result significant functional impairment and psychological burden. Due to the rarity of this condition there are no clear treatment guidelines, those few available focused on paediatric cases. Reports surgical management isolated lacking. We present here through partial amputation enlarged rays right hand an individual affected low-grade mutation.
The combination of short stature, auditory canal atresia, mandibular hypoplasia, and skeletal abnormalities (SAMS, OMIM: 602471) has been reported as an ultra-rare, autosomal-recessive developmental disorder with unique anomalies. To the present date, only four affected individuals have reported. There are several striking orthopaedic diagnoses within SAMS syndrome. In particular, scapulohumoral synostosis bilateral congenital ventral dislocation hips. purpose this report is to underline...