A5001420947- Exercise and Physiological Responses
- Cardiovascular and exercise physiology
- Vitamin D Research Studies
- Vitamin C and Antioxidants Research
- Protein Degradation and Inhibitors
- Vitamin K Research Studies
- Multiple Myeloma Research and Treatments
- Physical Activity and Health
- Ubiquitin and proteasome pathways
- Muscle metabolism and nutrition
- Cardiac Health and Mental Health
- Adipose Tissue and Metabolism
- Chronic Lymphocytic Leukemia Research
- Thermoregulation and physiological responses
- Cardiac Imaging and Diagnostics
- Diet and metabolism studies
- Sports Performance and Training
- Immune Cell Function and Interaction
- Eating Disorders and Behaviors
- CAR-T cell therapy research
Heriot-Watt University
2024
University of Glasgow
2021-2022
Edinburgh Napier University
2018-2021
Age UK
2019-2021
University of Strathclyde
2016-2021
GlaxoSmithKline (United Kingdom)
2016-2021
North Hertfordshire College
2016
The impact of covalent binding on PROTAC-mediated degradation BTK was investigated through the preparation both and reversible PROTACs derived from inhibitor ibrutinib. It determined that a PROTAC inhibited despite evidence target engagement, while observed with PROTAC. These observations were consistently found when able to recruit either IAP or cereblon E3 ligases employed. Proteomics analysis use covalently bound did not result in targets, for some reversibly targets. This observation...
Research into degradation of cellular proteins induced by small molecule agents known as Protacs has gathered pace recently. This article reviews recent progress and assesses the challenges to be addressed enable clinical evaluation agents.
Our aim was to investigate the acute effects of a single bout high intensity intermittent training (HIIT) on glucose tolerance and other physiological metabolic markers in non-diabetic older adults. Fourteen healthy adults (age, 64 ± 2 y; BMI, 25.7 2.8 kg·m-2) performed two exercise trials: continuous moderate (MOD) HIIT, with response an oral test (OGTT) determined <24 hours after. Inflammatory, haematological, lipid parameters were also assessed day after each trial. There effect trials...
High-intensity intermittent training (HIIT) has been shown to reduce the risk of chronic conditions including development type 2 diabetes mellitus (T2DM). Independently, a low vitamin D status also linked prevalence T2DM. The aim this study was investigate if there synergistic metabolic effect HIIT and supplementation on glycemic control. A total 20 male female participants (age, 34 ± 9 year; BMI, 31.4 2.8 kg·m−2) completed 6 weeks HIIT, were randomized ingest 100 μg·day-1 D3 or placebo....
Abstract Background Regular participation in resistance exercise is known to have broad-ranging health benefits and for this reason prominent the current physical activity guidelines. Recovery after such important several populations across age range nutritional strategies enhance recovery modulate post-exercise physiological processes are widely studied, yet effective remain elusive. Vitamin K2 supplementation has emerged as a potential candidate, aim of study, therefore, test hypothesis...
What is the central question of this study? Does exercise affect vitamin D receptor expression in T lymphocytes young, middle-aged and older adults? main finding its importance? Moderate-intensity cycling increases D-deficient men, independent age, presenting a strategy to combat prevalence deficiency.Vitamin plays key role modulation immune system, mediated through intracellular (VDR). Exercise has been shown influence activity availability VDR. The aim study was investigate effect age on...
The aim of this study was to assess match time courses on hydration, wellness, and sleep as well the interrelationship between these variables in youth national soccer players.
Abstract Purpose Exercise is known to acutely affect T-lymphocyte populations in the peripheral blood, which intensity- and duration-dependent. However, effects of longer duration endurance exercise (>5 h) on T-cells days following are unknown. The aim this study was investigate circulating T-cell changes that occur response an ultra-endurance event, may provide insight into inflammatory exercise. Methods Ten individuals (m = 7, f 3) completing Ironman 70.3 event volunteered for study....
Targeted protein degradation is an emerging new strategy for the modulation of intracellular levels with applications in chemical biology and drug discovery. One approach to enable this redirect ubiquitin-proteasome system mark degrade target proteins interest (POIs) through use proteolysis targeting chimeras (PROTACs). Although great progress has been made enabling PROTACs as a platform, there are still limited number E3 ligases that have employed PROTAC design. Herein we report novel...
Abstract Background: Regular participation in resistance exercise is known to have broad ranging health benefits and for this reason prominent the current physical activity guidelines. Recovery after such important several populations across age range nutritional strategies enhance recovery modulate post-exercise physiological processes are widely studied, yet effective remain elusive. Vitamin K2 supplementation has emerged as a potential candidate aim of study, therefore, test hypothesis...