We have examined the effects of extracellular and intracellular Ca2+ concentrations upon basal insulin-stimulated 2-deoxyglucose uptake in isolated rat adipocytes. In absence Ca2+, both glucose were significantly reduced. Insulin-stimulated transport was optimal at 1 2 mM Ca2+. Further increases concentration (3 mM) diminished uptake. When augmented by ionomycin (1 microM), reduced 3 mM. The levels free then measured with indicator fura-2. correlation between magnitude revealed that effect...

While few soldiers may have read the works of Epictetus or Marcus Aurelius, it is undoubtedly true that ancient philosophy known as Stoicism guides actions many in military. Soldiers and seamen learn early their training to suck up, endure, put aside feelings get on with mission. Stoic Warriors first book delve deeply into legacy this relationship, exploring what actually is, role plays character military (both modern), its powerful value a life. Marshalling anecdotes from history - ranging...

In this paper I want to consider the value of friendship from an Aristotelian point view. The issue is current interest given recent challenges impartialist ethics take more seriously commitments and attachments a person.' what follows enter that debate in only restricted way by strengthening challenge articulated Aristotle's systematic defense shared life. After some introductory remarks, begin considering notion good living or happiness (eudaimonia)2 for individual necessarily includes...

Part 1 Introduction 2 Acknowledgements Chapter 3 Permanent Happiness: Aristotle and Solon 4 on Virtue Happiness 5 Eudaimonia 6 the Human Good: An Overview 7 A False Doctrine of Mean 8 Reason 9 The Discernment Perception: Aristotelian Conception Private Public Rationality 10 Akrasia, Eudaimonia, Psychology Action 11 Learning to Be Good 12 Habituation Character 13 Being Properly Affected: Virtues Feelings in Aristotle's Ethics 14 Friendship 15 Feminism Rational Ideal 16 Suggested Readings 17 Authors

This book is the first to offer a detailed analysis of Aristotelian and Kantian ethics together, in way that remains faithful texts responsive debates contemporary ethics. Recent moral philosophy has seen revival interest concept virtue, with it reassessment role virtue work Aristotle Kant. brings re-assessment new level sophistication. Nancy Sherman argues Kant preserves notion his theory bears recognisable traces Stoic traditions, complex anthropology morals him into surprising alliance...

We have recently provided evidence that elevated levels of cytosolic free Ca2+ ([Ca2+]i) decreased insulinstimulated glucose uptake in isolated rat adipocytes. To investigate the mechanism action, we examined effects [Ca2+]i on insulin binding, autophosphorylation, and tyrosine kinase activity (TKA) receptors as well basal insulin-stimulated cellular distribution transporters. The latter was assessed by cytochalasin-B binding to plasma membrane fractions. Elevated concentrations were...

Two studies were conducted to demonstrate that maladaptive aspects of high and low Openness Experience related characterological impairment this aspect personality may define a new domain dysfunction. The 55-item Experiential Permeability Inventory (EPI; containing 4 scales) was developed demonstrated have acceptable psychometric properties. Evidence convergent, discriminant, incremental validity provided. These provide methodological framework for identifying developing dysfunction can...

Erectile dysfunction (ED) is common among men taking antihypertensive drugs to control blood pressure. We evaluated the safety and efficacy of sildenafil citrate for treating ED in multiple medications a randomized, double-blind, placebo-controlled trial.A total 568 (> or =18 years) with hypertension who were two more antihypertensives randomized (n = 281) matching placebo 287) 6-week double-blind trial followed by open-label phase during which all patients received sildenafil. Primary...

We assessed the change in confidence, relationships and self-esteem, its correlation with erectile function men ED treated sildenafil citrate first United States based, double-blind, placebo controlled, randomized trial by validated SEAR.This 12-week flexible dose (25, 50 or 100 mg) determined scores from baseline to end of treatment for 5 SEAR components (Sexual Relationship domain, Confidence Self-Esteem subscale [prespecified as primary point], Overall score), their correlations IIEF...

The domain of Openness within the Five-Factor Model (FFM) has received inconsistent support as a source for maladaptive personality functioning, at least when latter is confined to disorders included American Psychiatric Association's (APA) Diagnostic and Statistical Manual Mental Disorders (DSM-IV-TR; APA, ). However, an advantage FFM relative DSM-IV-TR that former was developed provide reasonably comprehensive description general structure. Rather than suggest inadequate because lacks much...

When we think about being good, morally good that is, what comes to mind is others, and in a less definite, though still important way, ourselves. One set of virtues which into consideration are generosity, beneficence, justice, with the focus perhaps, on welfare rights. In Hume's words, will never be able bear its own survey, has been wanting part mankind society.' definite benefit self too (as Hume himself argues), some directly, even those same may other occasions directed toward others....

Somatostatin (SRIF) binding, internalization, and intracellular processing in primary culture of anterior pituitary cells have been studied using somatostatin coupled to an electron-opaque marker, colloidal gold. Initially, after 2 min incubation (37 C), gold-conjugated SRIF is localized on the cell surface, with 38% marker being found around microvilli, 10% at junction secretion vesicles plasma membrane, 51% distributed over remaining areas membrane. There was no internalization this time....

In this paper, I explore self-empathy as a component in the healing of moral injury war. have written recently on subject, The Untold War, and particular, how soldiers experience guilt response to good bad luck, such surviving buddies or causing their deaths by accident (Sherman, 2010). This kind is obviously not restricted war, but war provides an important timely context for studying it. Imposing oneself, argue, way taking responsibility, even if one overimposes It can be morally fitting...

We evaluated the possible relationship between [Ca2+]i and glucose uptake in postabsorptive state postprandially adipocytes obtained from normal obese subjects, as well patients with non-insulin-dependent diabetes mellitus (NIDDM). Adipocytes isolated overnight-fasted NIDDM revealed high levels of (p less than 0.05 vs. control) association a decreased insulin-stimulated controls). In treated oral hypoglycemic agents, overnight fasting were increased 0.05), concomitantly further decrease...