About
Contact & Profiles
A5069693147
Research Areas
- DNA Repair Mechanisms
- PARP inhibition in cancer therapy
- Toxin Mechanisms and Immunotoxins
- Low-power high-performance VLSI design
Lomonosov Moscow State University
2020-2021
The PARP family consists of 17 members with diverse functions, including those related to cancer cells’ viability. Several inhibitors are great interest as innovative anticancer drugs, but they have low selectivity towards distinct and exert serious adverse effects. We describe a family-wide study the nicotinamide (NA) binding site, an important functional region in structure, using comparative bioinformatic analysis molecular modeling. Mutations NA site D-loop mobility around were...
10.3390/cancers13061201
article
EN
Cancers
2021-03-10
10.1134/s0006297920010095
article
EN
Biochemistry (Moscow)
2020-01-01
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