A5075963720- Pharmaceutical and Antibiotic Environmental Impacts
- Environmental Toxicology and Ecotoxicology
- Biofuel production and bioconversion
- Analytical chemistry methods development
- Microbial Metabolic Engineering and Bioproduction
- Pharmacological Effects and Assays
- Aquatic Ecosystems and Phytoplankton Dynamics
- Marine and coastal ecosystems
- Toxic Organic Pollutants Impact
- Enzyme Catalysis and Immobilization
- Chemical Synthesis and Characterization
- Petroleum Processing and Analysis
- Mass Spectrometry Techniques and Applications
- Soil and Water Nutrient Dynamics
- Marine Toxins and Detection Methods
- Radioactive element chemistry and processing
- Aquaculture disease management and microbiota
- Chemical Analysis and Environmental Impact
- Pesticide and Herbicide Environmental Studies
- Effects and risks of endocrine disrupting chemicals
- Extraction and Separation Processes
- Antibiotics Pharmacokinetics and Efficacy
- Pesticide Residue Analysis and Safety
- Catalysis for Biomass Conversion
- Water Treatment and Disinfection
Baylor University
2014-2025
Aquatic Systems (United States)
2014-2025
Clemson University
2017
Colorado State University
1996-2016
National Renewable Energy Laboratory
2007
Oak Ridge National Laboratory
1998-2003
The fermentation inhibition of yeast or bacteria by lignocellulose-derived degradation products, during hexose/pentose co-fermentation, is a major bottleneck for cost-effective lignocellulosic biorefineries. To engineer microbial strains improved performance, it critical to understand the mechanisms that affect fermentative organisms in presence components hydrolysate. development synthetic hydrolysate (SH) media with composition similar actual biomass will be an important advancement...
Increasing evidence indicates widespread occurrence of pharmaceuticals and personal care products (PPCPs) in municipal effluent discharges surface waters. Studies that characterize the fate effects PPCPs aquatic systems are limited, to our knowledge, data regarding pharmaceutical accumulation fish effluent-dominated ecosystems have not been previously reported. In present study, populations were sampled from a reference stream an north Texas, USA. Lepomis macrochirus, Ictalurus punctatus,...
Abstract Pharmaceuticals and personal care products are being increasingly reported in a variety of biological matrices, including fish tissue; however, screening studies have presently not encompassed broad geographical areas. A national pilot study was initiated the United States to assess accumulation pharmaceuticals sampled from five effluent‐dominated rivers that receive direct discharge wastewater treatment facilities Chicago, Illinois; Dallas, Texas; Orlando, Florida; Phoenix,...
A liquid chromatography−tandem mass spectrometry (LC−MS/MS) screening method has been developed targeting 23 pharmaceuticals and 2 metabolites with differing physicochemical properties in fish tissue. Reversed-phase separation of target compounds was achieved using a C18 column nonlinear gradient consisting 0.1% (v/v) formic acid methanol. Eluted analytes were introduced into the analyzer positive or negative electrospray ionization, as appropriate. variety extraction solvents, polarity, pH,...
A variety of potentially inhibitory degradation products are produced during pretreatment lignocellulosic biomass. Qualitative and quantitative interrogation hydrolysates is paramount to identifying potential correlations between chemistries microbial inhibition in downstream bioconversion processes. In the present study, corn stover, poplar, pine feedstocks were pretreated under eight different chemical conditions, which representative leading Pretreatment processes included: 0.7%...
Corn stover is one of the leading feedstock candidates for commodity-scale biomass-to-ethanol processing. The composition water-soluble materials in corn has been determined with greater than 90% mass closure four five representative samples. percentage tested samples varied from 14 to 27% on a dry weight basis. Over 30 previously unknown constituents aqueous extracts were identified and quantified using variety chromatographic techniques. Monomeric sugars (primarily glucose fructose) found...
Though pharmaceuticals are increasingly observed in a variety of organisms from coastal and inland aquatic systems, trophic transfer food webs have not been reported. In this study, bioaccumulation select was investigated lower order effluent-dependent stream central Texas, USA, using isotope dilution liquid chromatography-tandem mass spectrometry (MS). A fish plasma model, initially developed laboratory studies, tested to examine versus predicted internal dose pharmaceuticals....
Researchers recognize that ionization state may influence the biological activity of weak acids and bases. Dissociation in aqueous solutions is controlled by pKa a compound pH matrix. Because many pharmaceuticals are implicitly designed as ionizable compounds, site-specific variability receiving waters introduce uncertainty to ecological risk assessments. The present study employed 48-h 7-d toxicity tests with Pimephales promelas exposed model base pharmaceutical sertraline over gradient...
Abstract There is a growing need to find alternatives crude oil as the primary feed stock for chemicals and fuel industry ethanol has been demonstrated be viable alternative. Among various stocks producing ethanol, poplar (Populus nigra × Populus maximowiczii) considered have great potential biorefinery feedstock in United States, due their widespread availability good productivity several parts of country. We optimized AFEX pretreatment conditions (180°C, 2:1 ammonia biomass loading, 233%...
German Environment Specimen Bank (GESB) fish tissue samples, collected from 14 different GESB locations, were analyzed for 15 pharmaceuticals, 2 pharmaceutical metabolites, and 12 personal care products. Only diphenhydramine desmethylsertraline, measured above MDL. Diphenhydramine (0.04-0.07 ng g(-1) ww) desmethylsertraline (1.65-3.28 at 4 respectively. The maximum concentrations of galaxolide (HHCB) (447 tonalide (AHTN) (15 the Rehlingen sampling site in Saar River. A significant decrease...
In recent years pharmaceuticals have been detected in aquatic systems receiving discharges of municipal and industrial effluents. Although diphenhydramine (DPH) has reported water, sediment, fish tissue, an understanding its impacts on organisms is lacking. Diphenhydramine multiple modes action (MOA) targeting the histamine H1, acetylcholine (ACh), 5-HT reuptake transporter receptors, as such used hundreds pharmaceutical formulations. The primary objective this study was to develop a...
Abstract The occurrence of pharmaceuticals in the environment presents a challenge growing concern. In contrast to many industrial compounds, undergo extensive testing prior their introduction environment. principle, therefore, it may be possible employ existing pharmacological safety data using biological “read‐across” methods support screening‐level bioaccumulation environmental risk assessment. However, few approaches and robust empirical sets exist, particularly for comparative...
A need exists to better understand the influence of pH on uptake and accumulation ionizable pharmaceuticals in fish. In present study, fathead minnows were exposed diphenhydramine (DPH; disassociation constant = 9.1) water for up 96 h at 3 nominal levels: 6.7, 7.7, 8.7. each case, an apparent steady state was reached by 24 h, allowing direct determination bioconcentration factor (BCF), blood-water partitioning (PBW,TOT), volume distribution (approximated from whole-body-plasma concentration...
Abstract Propranolol is a widely prescribed, nonselective β‐adrenergic receptor–blocking agent. has been detected in municipal effluents from the ng/L to low‐μg/L range. Like many therapeutics and other aquatic contaminants, propranolol distributed as racemic mixture ((R,S)‐propranolol hydrochloride). Although (S)‐enantiomer most active form mammals (up 100‐fold difference), no information available regarding enantiospecific toxicity of organisms. Acute chronic studies were conducted with...
Sulfamethoxazole (SMX) is among the most frequently detected antibiotics in environment, heavily used both human therapy and agriculture. Like other sulfonamides, SMX disrupts folate biosynthetic pathway bacteria, which was recently established as identical to that of plants, raising concerns over nontarget toxicity. Consequently, Lemna gibba exposed evaluate phytotoxic potency mode action (MOA) by HPLC-MS/MS measurement p-aminobenzoic acid (pABA) metabolite levels, a precursor biosynthesis...