New 1,3,4-thiadiazole thioglycosides linked to substituted arylidine systems were synthesized via glycosylation of the prepared thiol compounds. Click strategy was also used for synthesis new and 1,2,3-triazole hybrid glycosides by reaction acetylenic derivatives with different glycosyl azids followed deacetylation process. The cytotoxic activities compounds studied against HCT-116 (human colorectal carcinoma) MCF-7 breast adenocarcinoma) cell lines using MTT assay. results showed that key...

New 1,3,4-thiadiazole thioglycosides linked to a substituted arylidine system were synthesized via heterocyclization click 1,3-dipolar cycloaddition. The strategy was used for the synthesis of new and 1,2,3-triazole hybrid glycoside-based indolyl systems as novel molecules by reacting azide derivatives with corresponding acetylated glycosyl terminal acetylenes. cytotoxic activities compounds studied against HCT-116 (human colorectal carcinoma) MCF-7 breast adenocarcinoma) cell lines using...

Abstract New sulfonamide-triazole-glycoside hybrids derivatives were designed, synthesised, and investigated for anticancer efficacy. The target glycosides’ cytotoxic activity was studied with a panel of human cancer cell lines. Sulfonamide-based derivatives, 4 , 7 9 exhibited promising against HepG-2 MCF-7 (IC 50 = 8.39–16.90 μM 19.57–21.15 MCF-7) comparing doxorubicin 13.76 ± 0.45, 17.44 0.46 MCF-7, rescpectively). To detect the probable action mechanism, inhibitory these targets VEGFR-2,...

The toxicity that was caused by the developed medications for anticancer treatment is, unfortunately, an earnest problem stemming from various involved targets, and accordingly, intense research overcoming such a phenomenon remains indispensable. In current inquiry, innovative category of substituted quinazoline-based glycosides incorporating core 1,2,3-triazole attached to distinct acetylated likewise deprotected sugar segments are created produced synthetically. resulted...

Glycosyl heterocycles, being as nucleoside analogs with modified glycon and hybrid heterocycle motifs, are of considerable interest, thus, the targeted compounds were synthesized via a convenient efficient approach.New indolyl-thiadiazolyl thioglycosides scaffolds synthesized, starting reaction indole-3-carbaldehyde 2-aminothiadiazole-5-thiole followed by glycosylation deprotection. Likewise, new molecular hybrids comprising indole, thiadiazole, triazole glycosyl moieties utilizing click...

Novel substituted [1,2,3]triazolo[4,5-d]pyrimidine-7-one derivatives were synthesized using 1,2,3-triazolo-4-carboxamide derivative (2) by the reaction with carbon disulfide, triethoxymethane, 4-fluorobenzaldehyde and ethyl benzoate respectively. The S-glucoside, N-glycoside acyclic sugar analogs of new [1,2,3]triazolo[4,5-d]pyrimidines also synthesized. compounds tested for cytotoxicity in vitro anticancer activity versus human lung (A549), colon (HCT116) breast (MCF-7) cancer cell lines....

AbstractAbstractTwo new series of 4,5-difunctionalized 1-bromobenzyl[1,2,3]triazole (2a, 3a, 4a, 5a, and 6a) 1-(2-oxo-2-(p-tolylamino)ethyl-[1,2,3]triazole (2b, 3b, 4b, 5b, 6b) were synthesized using related 1-(azidomethyl)-4-bromobenzene 1a p-tolylcarbamoyl azide 1b respectively. The substituted [1,2,3]triazolo[4,5-d]pyrimidine-7-one derivatives (7a, 7b, 8a, 8b) by the reaction [1,2,3]triazolo 2a 2b with carbon disulfide in presence 10% sodium hydroxide/dimethylformamide and/or formic acid...

Abstract The current study reports new sulfonamide-triazole-glycoside hybrids' design, synthesis, and anticancer activity. target glycosides' cytotoxic activity was studied with a panel of human cancer cell lines. Azido sulfonamide compound 4 exhibited moderate against A-549 HCT-116 excellent potency HepG-2 MCF-7. Replacement the azido group 1,2,3-triazole- glycoside hybrids in 6-13 afforded variable activities tested lines ranging from weak to ones acetylated glycosides 6-9. On other hand,...

New pyridine-

Cancer is still the most upsetting threat for human life and its fighting strategies have acquired intensive research. The design synthesis of novel candidates their possible potent anticancer activity has become a major objective in drug discovery field. In current research, new 1,2,3-triazole glycosides linked to substituted pyridine system were prepared vis click chemistry approach. A number acetylenic substrates incorporating varied structural features applied reaction. Various sugar...

Cancer remains a main threat for human life and requires intensive research discovering developing treatment strategies. The design synthesis of novel functionalized hybrid structures as candidates anticancer activity investigation have been proven in the literature an efficient approach providing variety compounds. In current work, new compounds incorporating aryl- or heteroarylpyridine, 1,2,4-triazole, glycosyl moieties prepared via stepwise pathway starting from simple available against...

The development of efficient strategies for overcoming cancer remains a standing objective in medicinal chemistry. Design and synthesis new potent compounds contribute efficiently to chemotherapy strategy since molecular hybridization was found an designing candidates possible anticancer activities. Isoindole 1,3,4-thiadiazole as well glycosyl structures are known literature with their broad-spectrum activities, the most important which is activity. In this study, novel hybrid incorporating...

As an important strategy, including incorporation of more than active core in one molecule, for finding potent candidates against cancer cells, a number functionalized pyrazolopyridin derivatives linked to oxadiazole, dioxolane, acyclic sugar and fluorene ring systems, were synthesized through heterocyclization reactions.The derived hydrazone the corresponding C-nucleoside analog addition N-nucleoside also prepared.The behavior afforded compounds as possible cytotoxic agents human HTC116...

Abstract Compounds (I) and (XI) are used as starting materials for the syntheses of a variety heterocyclic compounds such (X), (XV), (XVI), (XVIII), (XIX), (XXI), (XXII).