A5058587158- Epigenetics and DNA Methylation
- Birth, Development, and Health
- Histone Deacetylase Inhibitors Research
- Pregnancy and preeclampsia studies
- Gestational Diabetes Research and Management
- Prenatal Screening and Diagnostics
- Ubiquitin and proteasome pathways
- Genetics and Neurodevelopmental Disorders
- Cancer-related Molecular Pathways
- Calpain Protease Function and Regulation
- Signaling Pathways in Disease
- Marine Sponges and Natural Products
- Cancer Genomics and Diagnostics
- Global Public Health Policies and Epidemiology
- Cancer Cells and Metastasis
- Neonatal Respiratory Health Research
- Ectopic Pregnancy Diagnosis and Management
- Global Maternal and Child Health
- Chemical Reactions and Isotopes
- Aquaculture disease management and microbiota
- Maternal and Perinatal Health Interventions
- Marine Invertebrate Physiology and Ecology
- Advanced Breast Cancer Therapies
- Sirtuins and Resveratrol in Medicine
- Genomics and Chromatin Dynamics
University of Utah Health Care
2024
University of Utah
2021-2023
Intermountain Healthcare
2022
Cotton (United States)
2022
Vanderbilt University
2016-2021
Boston University
2000-2015
EMT and MET comprise the processes by which cells transit between epithelial mesenchymal states, they play integral roles in both normal development cancer metastasis. This article reviews these molecular pathways that contribute to them. First, we compare embryogenesis with We then discuss signaling differential expression down-regulation of receptors tumor stromal cells, a role further delve into clinical implications several types tumors, lastly, epigenetic events regulate EMT/MET...
Ovarian cancer is difficult to treat due absence of selective drugs and tendency platinum promote resistance. Combination therapy using epigenetic predicted be a beneficial alternative.This study investigated the effects combination therapies two structurally different histone deacetylase (HDAC) inhibitors (HDACi), sodium butyrate suberanilohydroxamic acid (SAHA), with calpain inhibitor calpeptin on characteristically ovarian cell lines, CAOV-3 SKOV-3.Suboptimal doses HDACi produced several...
In efforts to reduce maternal and neonatal mortality, it is recommended that all pregnant women be counseled on signs of pregnancy related complications illness. resource limited settings, such counselling may task-shifted lay health workers. We conducted a community-based cross-sectional survey community workers/volunteers in North East Kamagambo the Rongo Sub- County Migori County, Kenya, between January-April 2018. A tool was administered through face-to-face interviews investigate level...
NF-κB is an evolutionarily conserved eukaryotic transcription factor that plays a role in many important developmental and immune-related processes by activating target gene expression. The goal of these experiments was to define the sequences required for sea anemone NF-κB's intrinsic transactivation activity using mutant proteins with serial deletions N- C-terminal sequences. Deletion mutants were constructed missing 15, 32 or 47 amino acids (aa) N-terminal 17, 27 aa 440 protein from...
Objective: To derive and test the implications of a sex-specific fetal growth standard. Design: Secondary analysis prospective observational cohort. Setting: Eight U.S. centers. Population or Sample: Nulliparas followed longitudinally through pregnancy. A lower-risk subgroup (exclusions: chronic hypertension, pre-gestational diabetes, suspected aneuploidy, preterm delivery) was selected for equation derivation. Methods: Fetal weights at 14-20 weeks, 22-29 birth were used to equation. We...
To derive a prescriptive sex-specific fetal growth standard and assess clinical management outcomes according to status.
Abstract Objective Our objective was to determine whether genetic risk scores (GRSs) of offspring can be accurately estimated from parental DNA. Methods Whole genome sequencing data a cohort forty-seven multi-generation Utah families were used extract single nucleotide polymorphism (SNP) at loci associated with the following traits: birth weight (BW), fasting plasma glucose (FPG), blood pressure (BP), body mass index (BMI), height, and type 2 diabetes (T2D). Offspring GRSs for each trait...
Objective We sought to investigate the positive predictive value of ultrasound-diagnosed fetal growth restriction (FGR) for estimating small gestational age (SGA) at birth. Secondary objectives were describe clinical interventions performed as a result FGR diagnosis. Study Design This was retrospective cohort pregnancies diagnosed with over 3 years single institution. Maternal demographics, antenatal and delivery data, neonatal data collected. Descriptive statistics linear regression...