A5020909357- CRISPR and Genetic Engineering
- Chromosomal and Genetic Variations
- Microtubule and mitosis dynamics
- Plant Molecular Biology Research
- Developmental Biology and Gene Regulation
- Advanced biosensing and bioanalysis techniques
- Plant Reproductive Biology
- Insect behavior and control techniques
- Genetic and Clinical Aspects of Sex Determination and Chromosomal Abnormalities
- Genetics, Aging, and Longevity in Model Organisms
- Insect Resistance and Genetics
- Pesticide Exposure and Toxicity
- Genetics, Bioinformatics, and Biomedical Research
- Nutrition, Genetics, and Disease
- Plant Surface Properties and Treatments
- Plant biochemistry and biosynthesis
- Trace Elements in Health
- Plant Physiology and Cultivation Studies
- Aquaculture disease management and microbiota
- Marine Invertebrate Physiology and Ecology
- RNA modifications and cancer
- RNA and protein synthesis mechanisms
- Reproductive Biology and Fertility
- Plant Disease Resistance and Genetics
- Marine Sponges and Natural Products
Child Trends
2017-2019
Boston University
2011-2016
New York University
2000-2011
Howard Hughes Medical Institute
2000-2011
University of Connecticut
1996
Centro de Investigación y Desarrollo
1992
The Drosophila egg chamber provides a useful model for examining mechanisms by which cell fates are specified and maintained in the context of complex tissue. is also an excellent understanding mechanism cytoskeletal filaments organized critical interplay between organization, polarity establishment, fate specification. Previous work has shown that Egalitarian (Egl) required specification maintenance oocyte fate. Mutants egl either completely fail to specify oocyte, or if specified,...
A low-pressure injection method for introducing chemical formulations into trees is presented. The apparatus consists of a plastic injector and tube providing pressure 60 to 80 kPa, which below the injurious level xylem. efficiency was determined by injecting PTS, marker apoplastic flux dye solutions, rubidium chloride young trees, main scaffolds, or tree trunks. depth hole drilled) number injections necessary distribute solutions also determined. injected moved mainly upward through older...
Transposable selfish genetic elements have the potential to cause debilitating mutations as they replicate and reinsert within genome. Therefore, it is critical keep cellular levels of these low. This especially true in germline where could affect viability next generation. A class small noncoding RNAs, Piwi-associated responsible for silencing transposable most organisms. Several proteins been identified playing essential roles piRNA generation transposon silencing. However, part their...
Abstract The Drosophila oocyte develops from a cluster of 16 interconnected cells that derive common progenitor. One these cells, the oocyte, arrests in meiosis. other endoreplicate their DNA and produce mRNAs proteins they traffic to along polarized microtubule cytoskeleton shared by entire cyst. Therefore, oogenesis is an attractive system for study cell cycle control polarity. We carried out clonal screen on right arm chromosome 3 female sterile mutations using FLP-FRT-ovoD identify new...
Maintenance of genome integrity in germ cells is crucial for the success future generations. In Drosophila, and mammals, transposable element activity germline can cause DNA breakage sterility. Recent studies have shown that proteins involved piRNA (PIWI-interacting RNA) biogenesis are necessary retrotransposon silencing Drosophila germline. Females mutant genes pathway produce eggs with patterning defects result from Chk-2 (checkpoint kinase-2) damage checkpoint activation. Here we show...
NF-κB is an evolutionarily conserved eukaryotic transcription factor that plays a role in many important developmental and immune-related processes by activating target gene expression. The goal of these experiments was to define the sequences required for sea anemone NF-κB's intrinsic transactivation activity using mutant proteins with serial deletions N- C-terminal sequences. Deletion mutants were constructed missing 15, 32 or 47 amino acids (aa) N-terminal 17, 27 aa 440 protein from...
There is an intricate network of molecules called cell fate determinants that instruct the cells embryo to take on either anterior or posterior fate. In a lively Perspective, Lehmann and her colleagues discuss new findings in fruit fly identify key protein, PAR-1, which ensures are themselves located correct region oocyte. this way, anterior-posterior axis set up egg before fertilization.