A5004017340- Agriculture and Biological Studies
- Cancer therapeutics and mechanisms
- Pharmacological Effects of Natural Compounds
- Insect and Pesticide Research
- Natural product bioactivities and synthesis
- Silymarin and Mushroom Poisoning
- Plant tissue culture and regeneration
- Microbial Natural Products and Biosynthesis
- Physiological and biochemical adaptations
- Advances in Cucurbitaceae Research
- Genetics, Aging, and Longevity in Model Organisms
- Plant Toxicity and Pharmacological Properties
- Nanocluster Synthesis and Applications
- Cynara cardunculus studies
- Genomics, phytochemicals, and oxidative stress
- Free Radicals and Antioxidants
- Biological Activity of Diterpenoids and Biflavonoids
- Cholinesterase and Neurodegenerative Diseases
- Fungal Biology and Applications
- Synthesis and bioactivity of alkaloids
- Mycorrhizal Fungi and Plant Interactions
- Polyoxometalates: Synthesis and Applications
- Lung Cancer Research Studies
- Computational Drug Discovery Methods
- Drug Transport and Resistance Mechanisms
Ural Federal University
2018-2024
Using the Drosophila melanogaster model object, presence of protective properties in 10% Prunella grandiflora L. (Lamiaceae) extract was determined relation to toxic and cytotoxic effects antitumor drug etoposide two concentrations 800 8000 µg/kg nutrient medium. The grass P. collected flowering phase Sverdlovsk region (N 56°09'22.0'', E 058°32'19.6'') 2021. No genotoxic manifestations were found. Comparative characteristics wing parameters under influence at a dose mg showed significant...
One of the most important directions in medical practice involves exploration protectors and adaptogens to mitigate side effects associated with use antitumor potent medications. The extracts medicinal plants are actively tested as protectors. In connection this, aim research was determine effectiveness protective properties Silybum marianum extract against drugs 'etoposide' 'methotrexate' at concentrations 800 μg/kg using model object Drosophila melanogaster. To analyse properties,...
In our study, four species of wood-decaying fungi with perennial fruiting bodies were used as the source biologically active compounds (BACs) - Inonotus obliquus (chaga), Fomitopsis pinicola, Fomes fomentarius, and Ganoderma applanatum. Fungi have a wide range secondary metabolites but are much less frequently than plants in both folk official medicine. Fungotherapy could be considered promising trend development modern natural therapy. Therefore, qualitative quantitative analyses extracts...
Betonica officinalis L. is a promising representative of the Lamiaceae family in relation to study neurotoxicology and genetic activity. The extract was tested at 2 5% concentrations relative total volume nutrient substrate for cultivation model object Drosophila melanogaster. B. officinalis, DNA damage an increase level brain vacuolization D. melanogaster were recorded.
The protective properties of the extract Monarda fistulosa var. menthifolia were tested when used together with antitumor drug etoposide on Drosophila melanogaster. 1%, 10% extracts M. tested, separately and at 800 µg kg−1 nutrient medium. genotoxic effect was determined using SMART method. Cytotoxicity by assessing regulated cell death (RCD). While 1% (20 mg mL−1) did not show genotoxicity, had antigenotoxicity, reducing genetic activity anticancer etoposide, (200 it showed geno- cytotoxicity.
The paper presents the results of evaluating genetic and cytogenetic toxicity etoposide, as well evaluation protective properties aspirin against etoposide in C57Bl/6J mice. activity assessment was carried out using chromosome aberration analysis metaphase cells. Etoposide tested at a concentration 15 3 mg/kg — 25 animal. showed that exhibits both doses, mg/kg. regarding are ambiguous require further experiments.
The article analyzes the feeding intensity, chemotaxis of larvae and changes in expression sqh gene D. melanogaster individuals cultivated on a nutrient medium with introduction ethanol extract from S. marianum seeds under pretreatment hydrostatic pressure 5, 10, 15 20 MPa. preferred respect to seed without prior exposure was revealed. Changes intensity nutrition experimental groups were not registered. A hypo-expressive direction activity found when growing an treated levels Variants...
Determination of toxic, genotoxic and cytotoxic effects Drosophila melanogaster for Monarda fistulosa var. menthifolia, M. fistulosa, didyma media was carried out. The Oregon-R line used to test toxic manifestations in a number indicators: fecundity, early late embryonic mortality offspring total lethality individuals (LC50). effect recorded using SMART. change the wing shape regulated cell death determined. grown on nutrient medium with addition an extract as well F1 at stage development...
The purpose of this work to determine the influence different concentration methotrexate on apoptosis level in ovaries Drosophila melanogaster at normal and elevated temperature during development. In experiment was used 300 hybrid individuals “Oregon-R x vg” with spontaneous mutation like Beadex phenotype. We investigated six group: control, a group after 400 mkg/ kg medium treatment, 2000 dose, 10000 28 C treatment together. During we found that checkpoint #1 reaches maximum values MTX...
The study of the realization hereditary variability on background already existing mutant alleles certain genes is an important part biomedical and population investigations, including human diseases. change in viability parameters individuals wild type Belgorod strain vestigial Drosophila melanogaster over course breeding has been researched. changes during have recorded hybrid heterozygous for vestigial, namely, fertility embryonic lethality offspring × direct selection, presence regulated...
The data on the protective properties of Prunella grandiflora L. extract were obtained when used together with anticancer drug etoposide experimental strain Drosophila melanogaster . combined use and 10% P. decreased mortality in D. individuals to 15% doubled average individual fertility compared this cytostatic without extract. Using SMART method, presence antigenotoxic effect was identified, which manifests itself through absence chromosomal aberrations.