A5017016306- Bacterial Infections and Vaccines
- Pneumonia and Respiratory Infections
- Vaccine Coverage and Hesitancy
- Influenza Virus Research Studies
- Health and Medical Studies
- Virology and Viral Diseases
- Respiratory viral infections research
- Infective Endocarditis Diagnosis and Management
- Human Health and Disease
- SARS-CoV-2 and COVID-19 Research
- Parvovirus B19 Infection Studies
- Medical History and Research
- Healthcare Systems and Public Health
- Reproductive tract infections research
- Syphilis Diagnosis and Treatment
- Child and Adolescent Health
- Hepatitis C virus research
- Gestational Diabetes Research and Management
- German History and Society
- Bacillus and Francisella bacterial research
- Infectious Encephalopathies and Encephalitis
- Palliative Care and End-of-Life Issues
- Poxvirus research and outbreaks
- Intramuscular injections and effects
- Historical and Political Studies
Kentucky Department for Public Health
2022-2025
University of Kentucky
2016-2023
McMaster University
2020
California Department of Public Health
2008-2018
Kaiser Permanente Fontana Medical Center
2017
University of Zurich
2015
Meningitis Now
2012
National Center for Immunization and Respiratory Diseases
2012
The Centers
2012
Centers for Disease Control and Prevention
2012
Pandemic influenza A(H1N1) emerged rapidly in California April 2009. Preliminary comparisons with seasonal suggest that pandemic 2009 disproportionately affects younger ages and causes generally mild disease.To describe the clinical epidemiologic features of cases led to hospitalization or death.Statewide enhanced public health surveillance residents who were hospitalized died laboratory evidence infection reported Department Public Health between 23 August 11, 2009.Characteristics fatal...
Although laboratory evidence suggests that antibody responses following COVID-19 vaccination provide better neutralization of some circulating variants than does natural infection (1,2), few real-world epidemiologic studies exist to support the benefit for previously infected persons. This report details findings a case-control evaluation association between and SARS-CoV-2 reinfection in Kentucky during May-June 2021 among persons with 2020. residents who were not vaccinated had 2.34 times...
A POORLY controlled vaccine-preventable disease in the United States, despite a well-established childhood vaccination program and high coverage. 1Although infants have substantially higher rates of pertussis compared with other age groups, data from National Notifiable Diseases Surveillance System reflect recent increase number reported cases among children aged 7 to 10 years.In 2010, this group had second highest incidence States. 2 The changing epidemiology raises important questions...
BACKGROUND: In 2010, 9120 cases of pertussis were reported in California, more than any year since 1947. Although this resurgence has been widely attributed to waning immunity the acellular vaccine, role vaccine refusal not explored published literature. Many factors likely contributed outbreak, including cyclical nature pertussis, improved diagnosis, and immunity; however, it is important understand if clustering unvaccinated individuals also played a role. METHODS: We analyzed nonmedical...
Most severe and fatal cases of pertussis occur in infants <8 weeks age, before initiation the primary vaccine series. Women are recommended to receive tetanus, diphtheria, acellular (Tdap) at start third trimester each pregnancy optimize transplacental transfer antibodies fetus. This recommendation was made by Advisory Committee for Immunization Practices based on immunogenicity data, no studies United States have yet evaluated effectiveness this strategy reducing incidence infants. We a...
Background. In the current era, most pertussis deaths occur in infants <3 months of age. Leukocytosis with lymphocytosis and pneumonia are commonly observed among cases severe pertussis.
All US women are recommended to receive a tetanus, diphtheria, and acellular pertussis (Tdap) vaccine at 27-36 weeks gestation during each pregnancy reduce the risk of their infants. The impact this strategy on severity disease among infected infants has not been evaluated. We use retrospective cohort study design evaluating whether pertussis-infected born in 2011-2015 whose mothers received Tdap had less severe pertussis, resulting lower hospitalization or intensive care unit admission...
Subacute sclerosing panencephalitis (SSPE) is a fatal complication of measles. We reviewed California cases from 1998-2015 to understand risk factors for SPPE and estimate incidence.SSPE had clinically compatible symptoms measles antibody detection in cerebrospinal fluid (CSF) or medical record documentation SSPE. Cases were identified though state death certificate search, Centers Disease Control Prevention reports, investigations undiagnosed neurologic disease. Measles CSF was performed by...
Reported influenza-associated neurologic complications are generally limited to case series or reports. We conducted a population-based study of manifestations associated with severe and fatal influenza A(H1N1)pdm09 (2009 H1N1) cases.Medical records patients (hospitalized in intensive care unit) laboratory-confirmed 2009 H1N1 reported the California Department Public Health from 15 April through 31 December were reviewed identify those primary neurological manifestations. Cases secondary...
Several clusters of serogroup C meningococcal disease among men who have sex with (MSM) been reported in the United States recent years. The epidemiology and risk MSM is not well described.All cases aged 18-64 years to National Notifiable Disease Surveillance System between January 2012 June 2015 were reviewed. Characteristics known be (non-MSM) described. Annualized incidence rates non-MSM compared through calculation relative 95% confidence intervals. Isolates from characterized using...
<h3>Objective</h3> To describe clinical and epidemiologic features of 2009 novel influenza A(H1N1) in children. <h3>Design</h3> Analysis data obtained from standardized report forms medical records. <h3>Setting</h3> Statewide public health surveillance California. <h3>Participants</h3> Three hundred forty-five children who were hospitalized with or died A(H1N1). <h3>Main Exposure</h3> Laboratory-confirmed Outcome Measures</h3> Hospitalization death. <h3>Results</h3> From April 23 to August...
Pertussis in young infants is a unique, severe, afebrile, cough illness that frequently fatal.All pertussis cases ≤120 days of age admitted to pediatric intensive care unit California between October 1, 2013, and April 25, 2015, were evaluated.Of 100 patients unit, there 5 deaths. The white blood cell counts the fatal significantly higher than nonfatal cases. Thirty-four percent intubated, 18% received inotropic and/or vasoactive support, 22% steroid, 4% extracorporal membrane oxygenation,...
On January 31, 2016, the Santa Clara County Public Health Department (SCCPHD) was notified of a suspected case meningococcal disease in university undergraduate student. By February 2, two additional cases had been reported students living on same campus. The index patient (patient A) required intensive care, whereas patients B and C milder illness; there were no deaths. All three part overlapping social networks attended events during week before onset A's symptoms, but whether they direct...
During March 4-August 11, 2016, 25 outbreak-associated cases of meningococcal disease, including two deaths (8% case-fatality ratio), were reported in Southern California. Twenty-four the caused by serogroup C Neisseria meningitidis (NmC) and one N. with an undetermined (Figure). On June 24, response to this increase NmC cases, primarily among men who have sex (MSM) Los Angeles County, city Long Beach, Orange California Department Public Health (CDPH) issued a press release health advisory,...
Pertussis has recently re-emerged in the United States. Timely surveillance is vital to estimate burden of this disease accurately and guide public health response. However, pertussis limited by delays reporting, consolidation dissemination data relevant stakeholders. We fit assessed a real-time predictive Google model for California using weekly incidence from 2009-2014.The linear was moderately accurate (r = 0.88). Our findings cautiously offer complementary, signal enhance help further...
Since 2012, three clusters of serogroup C meningococcal disease among men who have sex with (MSM) been reported in the United States. During 13 cases MSM were by New York City Department Health and Mental Hygiene (1); over a 5-month period during 2012–2013, Los Angeles County Public four MSM; May–June 2015, Chicago seven greater area. not previously considered at increased risk for disease. Determining outbreak thresholds* special populations unknown size (such as MSM) can be difficult. The...
We identified 27 cases of hepatitis A among international adoptees (5 persons), their direct or indirect contacts (20 and unvaccinated travelers to the adoptees' countries (2 persons). Most occurred nontraveling adoptees, suggesting need extend prevention guidelines include vaccination for at-risk nontravelers.
Introduction: California experienced pertussis epidemics in 2010 and 2014, with more than 9000 11,000 reported cases, respectively. Using an ecologic study design, we compared age-specific incidence for persons ≤20 years of age 2014 to describe any changes disease burden that may be attributable vaccination policy occurred during interepidemic years. Methods: We evaluated surveillance data cases 20 younger onset from January 1, December 31, or 2014. Age-specific rates were calculated each...
MenB-4C is a recently licensed meningococcal serogroup B vaccine. For vaccine licensure, short-term efficacy was inferred from serum bactericidal antibody (SBA) titers against 3 antigen-specific indicator strains, which are not necessarily representative of US disease-causing strains.A total 4923 students were immunized with in response to an outbreak at university. Serum samples obtained 1.5-2 months 106 who received the recommended 2 doses and 52 unvaccinated students. Follow-up 7 42...